Signaling pathways in early cardiac development

2010 ◽  
Vol 3 (2) ◽  
pp. 191-205 ◽  
Author(s):  
Wenrui Liu ◽  
Ann C. Foley
Keyword(s):  
Signaling Pathways ◽  
Cardiac Development ◽  
Early Cardiac Development

scholarly journals Rho-Kinase Inhibition During Early Cardiac Development Causes Arrhythmogenic Right Ventricular Cardiomyopathy in Mice

2015 ◽  
Vol 35 (10) ◽  
pp. 2172-2184 ◽  
Author(s):  
Alia Ellawindy ◽  
Kimio Satoh ◽  
Shinichiro Sunamura ◽  
Nobuhiro Kikuchi ◽  
Kota Suzuki ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Cardiac Development ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Rho Kinase ◽  
Ventricular Cardiomyopathy ◽  
Kinase Inhibition ◽  
Early Cardiac Development

scholarly journals ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish

2008 ◽  
Vol 317 (2) ◽  
pp. 486-496 ◽  
Author(s):  
Xianghu Qu ◽  
Haibo Jia ◽  
Deborah M. Garrity ◽  
Kevin Tompkins ◽  
Lorene Batts ◽  
...  
Keyword(s):  
Cardiac Development ◽  
Myocyte Proliferation ◽  
Early Cardiac Development

scholarly journals A temporal transcriptome and methylome in human embryonic stem cell-derived cardiomyocytes identifies novel regulators of early cardiac development

Epigenetics ◽  
2018 ◽  
Vol 13 (10-11) ◽  
pp. 1013-1026 ◽  
Author(s):  
Kai Fu ◽  
Haruko Nakano ◽  
Marco Morselli ◽  
Tiffany Chen ◽  
Herman Pappoe ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Cardiac Development ◽  
Embryonic Stem ◽  
Early Cardiac Development

scholarly journals Zebrafish in the Study of Early Cardiac Development

2012 ◽  
Vol 110 (6) ◽  
pp. 870-874 ◽  
Author(s):  
Jiandong Liu ◽  
Didier Y.R. Stainier
Keyword(s):  
Cardiac Development ◽  
Early Cardiac Development

Expression of nebulette during early cardiac development

2007 ◽  
Vol 64 (4) ◽  
pp. 258-273 ◽  
Author(s):  
Michael Esham ◽  
Kourtney Bryan ◽  
Jennifer Milnes ◽  
William B. Holmes ◽  
Carole L. Moncman
Keyword(s):  
Cardiac Development ◽  
Early Cardiac Development

scholarly journals From mammals to fish and back again: discovering new regulators of early cardiac development

2017 ◽  
Vol 145 ◽  
pp. S142
Author(s):  
Xuefei Yuan ◽  
Mengyi Song ◽  
Patrick Devine ◽  
Benoit Bruneau ◽  
Michael Wilson ◽  
...  
Keyword(s):  
Cardiac Development ◽  
Early Cardiac Development

scholarly journals Early cardiac development: a view from stem cells to embryos

2012 ◽  
Vol 96 (3) ◽  
pp. 352-362 ◽  
Author(s):  
P. Van Vliet ◽  
S. M. Wu ◽  
S. Zaffran ◽  
M. Puceat
Keyword(s):  
Stem Cells ◽  
Cardiac Development ◽  
Early Cardiac Development

Molecular Characterization of Early Cardiac Development

2002 ◽  
pp. 215-238
Author(s):  
Thomas Brand ◽  
Birgit Andrée ◽  
Thomas Schlange
Keyword(s):  
Molecular Characterization ◽  
Cardiac Development ◽  
Early Cardiac Development

scholarly journals Distinct genes and pathways associated with transcriptome differences in early cardiac development between fast- and slow-growing broilers

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0207715 ◽  
Author(s):  
Jibin Zhang ◽  
Carl J. Schmidt ◽  
Susan J. Lamont
Keyword(s):  
Cardiac Development ◽  
Slow Growing ◽  
Early Cardiac Development

scholarly journals Spatiotemporal Gene Coexpression and Regulation in Mouse Cardiomyocytes of Early Cardiac Morphogenesis

2018 ◽  
Author(s):  
Yang Liu ◽  
Pengfei Lu ◽  
Yidong Wang ◽  
Bernice E. Morrow ◽  
Bin Zhou ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Signaling Pathways ◽  
Developmental Stages ◽  
Cardiac Development ◽  
Heart Defects ◽  
Enrichment Analysis ◽  
Mouse Heart ◽  
Atrioventricular Canal ◽  
Developmental Abnormalities ◽  
Highly Active

AbstractCardiac looping is an early morphogenic process critical for the formation of four-chambered mammalian hearts. To study the roles of signaling pathways, transcription factors (TFs) and genetic networks in the process, we constructed gene co-expression networks and identified gene modules highly activated in individual cardiomyocytes (CMs) at multiple anatomical regions and developmental stages. Function analyses of the module genes uncovered major pathways important for spatiotemporal CM differentiation. Interestingly, about half of the pathways were highly active in cardiomyocytes at outflow tract (OFT) and atrioventricular canal (AVC), including many well-known signaling pathways for cardiac development and several newly identified ones. Most of the OFT-AVC pathways were predicted to be regulated by 6 6 transcription factors (TFs) actively expressed at the OFT-AVC locations, with the prediction supported by motif enrichment analysis of the TF targets, including 10 TFs that have not been previously associated with cardiac development, e.g.,Etv5,Rbpms,andBaz2b. Finally, our study showed that the OFT-AVC TF targets were significantly enriched with genes associated with mouse heart developmental abnormalities and human congenital heart defects.

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