Protein Phosphatase Inhibitors Potentiate Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Rat Pancreatic Acinar Cells

1996 ◽  
Vol 225 (2) ◽  
pp. 520-524 ◽  
Author(s):  
Jason Hwang ◽  
M.Julia Bragado ◽  
Rui-Dong Duan ◽  
John A. Williams
Keyword(s):  
Protein Kinase ◽  
Protein Phosphatase ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Dependent Protein Kinase ◽  
Phosphatase Inhibitors ◽  
Protein Kinase Ii ◽  
Protein Phosphatase Inhibitors ◽  
Dependent Protein

scholarly journals Involvement of protein phosphatase 2C in dephosphorylation of autophosphorylated Ca2+/calmodulin-dependent protein kinase II.

1994 ◽  
Vol 64 ◽  
pp. 225
Author(s):  
Kohji Fukunaga ◽  
Takayasu Kobayashi ◽  
Shinri Tamura ◽  
Eishichi Miyamoto
Keyword(s):  
Protein Kinase ◽  
Protein Phosphatase ◽  
Dependent Protein Kinase ◽  
Protein Phosphatase 2C ◽  
Protein Kinase Ii ◽  
Dependent Protein

scholarly journals A Novel Protein Phosphatase That Dephosphorylates and Regulates Ca2+/Calmodulin-dependent Protein Kinase II

1998 ◽  
Vol 273 (4) ◽  
pp. 1904-1910 ◽  
Author(s):  
Atsuhiko Ishida ◽  
Isamu Kameshita ◽  
Hitoshi Fujisawa
Keyword(s):  
Protein Kinase ◽  
Protein Phosphatase ◽  
Dependent Protein Kinase ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Novel Protein

scholarly journals Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells.

1996 ◽  
Vol 44 (11) ◽  
pp. 1243-1250 ◽  
Author(s):  
L M Matovcik ◽  
A R Maranto ◽  
C J Soroka ◽  
F S Gorelick ◽  
J Smith ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Pancreatic Acinar Cells ◽  
Apical Region ◽  
Cam Kinase Ii ◽  
Cam Kinase ◽  
Dependent Protein Kinase ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Type 3 ◽  
Insp3 Receptor

The Type 3 inositol 1,4,5-trisphosphate (InsP3) receptor is expressed at high levels in gastrointestinal tissues. This receptor has 16 potential phosphorylation sites for calcium/calmodulin-dependent protein kinase II (CaM kinase II). To determine if the Type 3 InsP3 receptor is likely to be a physiologic substrate for CaM kinase II, localizations of the Type 3 InsP3 receptor and CaM kinase II were compared in tissues of the gastrointestinal tract. Cellular and subcellular localizations were determined by immunofluorescence microscopy in rat intestine, pancreas, and stomach, and in isolated rabbit gastric glands. Both proteins were found in the apical region of intestinal enterocytes, pancreatic acinar cells, and gastric parietal, chief, and surface mucous cells. CaM kinase II was found throughout the entire intracellular canalicular F-actin domain of parietal cells, whereas the type 3 InsP3 receptor was restricted to the neck region. Thus, in several gastrointestinal tissues the Type 3 InsP3 receptor is specifically localized to a portion of the apical cytoskeletal domain in which resides the calcium-responsive effector CaM kinase II.

Ca2+/calmodulin-dependent protein kinase II regulation by inhibitor 1 of protein phosphatase 1 alleviates necroptosis in high glucose-induced cardiomyocytes injury

2019 ◽  
Vol 163 ◽  
pp. 194-205 ◽  
Author(s):  
Linlin Sun ◽  
Yun Chen ◽  
Huiqin Luo ◽  
Mengting Xu ◽  
Guoliang Meng ◽  
...  
Keyword(s):  
Protein Kinase ◽  
High Glucose ◽  
Protein Phosphatase ◽  
Protein Phosphatase 1 ◽  
Dependent Protein Kinase ◽  
Protein Kinase Ii ◽  
Dependent Protein
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