Frequent Somatic Mutations ofhMSH3with Reference to Microsatellite Instability in Hereditary Nonpolyposis Colorectal Cancers

1997 ◽  
Vol 236 (2) ◽  
pp. 248-252 ◽  
Author(s):  
Yoshimitsu Akiyama ◽  
Naomi Tsubouchi ◽  
Yasuhito Yuasa
Keyword(s):  
Microsatellite Instability ◽  
Somatic Mutations ◽  
Colorectal Cancers ◽  
Hereditary Nonpolyposis

scholarly journals Hyperplastic Polyps Are Innocuous Lesions in Hereditary Nonpolyposis Colorectal Cancers

2011 ◽  
Vol 2011 ◽  
pp. 1-7
Author(s):  
D. Speake ◽  
J. O'Sullivan ◽  
D. G. Evans ◽  
F. Lalloo ◽  
J. Hill ◽  
...  
Keyword(s):  
Protein Expression ◽  
Microsatellite Instability ◽  
Molecular Level ◽  
Colorectal Cancers ◽  
Hyperplastic Polyps ◽  
Methylation Specific Pcr ◽  
Specific Pcr ◽  
Hereditary Nonpolyposis ◽  
Msi Analysis

Aims. To compare methylation profiles, protein expression, and microsatellite instability (MSI) of sporadic, HNPCC, and familial hyperplastic polyps (HPs).Methods. Methylation-specific PCR (MSP) and pyrosequencing assessed p16, MGMT, hMLH-1, MINT 1, and MINT 31 methylation. IHC (Immunohistochemistry) assessed Ki67, CK20, hMLH-1, hMSH-2, and hMSH-6 protein expression. MSI analysis was performed on those polyps with adequate DNA remaining.Results. 124 HPs were identified 78 sporadic, 21 HNPCC, 25 familial, and the HNPCC group demonstrated no significant differences in overall methylation (P=.186Chi2). The familial group demonstrated significantly less over all methylation levels (P=.004Chi2).Conclusions. HPs that occur in HNPCC have no more worrying features at a molecular level than those patients with HPs in a sporadic setting.

scholarly journals Loss or Somatic Mutations ofhMSH2Occur in Hereditary Nonpolyposis Colorectal Cancers withhMSH2Germline Mutations

1996 ◽  
Vol 87 (3) ◽  
pp. 279-287 ◽  
Author(s):  
Shi-Long Lu ◽  
Yoshimitsu Akiyama ◽  
Hiromi Nagasaki ◽  
Tadashi Nomizu ◽  
Eiichi Ikeda ◽  
...  
Keyword(s):  
Somatic Mutations ◽  
Colorectal Cancers ◽  
Hereditary Nonpolyposis

Somatic hMLH3 frameshift mutation in colorectal cancers with microsatellite instability

2001 ◽  
Vol 120 (5) ◽  
pp. A295-A295
Author(s):  
D CHANG ◽  
A GOEL ◽  
L RICCIARDIELLO ◽  
C ARNOLD ◽  
C BOLAND
Keyword(s):  
Microsatellite Instability ◽  
Frameshift Mutation ◽  
Colorectal Cancers

Mo1656 Microsatellite Instability of the Gastric and Colorectal Cancers As a Predictor for Synchronous Gastrointestinal Neoplasms

2014 ◽  
Vol 146 (5) ◽  
pp. S-628
Author(s):  
Young Baek Kim ◽  
Sun-Young Lee ◽  
Jeong Hwan Kim ◽  
In Kyung Sung ◽  
Hyung Seok Park ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Gastrointestinal Neoplasms ◽  
Colorectal Cancers

Differential clinicopathological features in microsatellite instability-positive colorectal cancers depending on CIMP status

2011 ◽  
Vol 459 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Jeong Mo Bae ◽  
Mi Jung Kim ◽  
Jung Ho Kim ◽  
Jae Moon Koh ◽  
Nam-Yun Cho ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Clinicopathological Features ◽  
Colorectal Cancers

Identification of Candidate Oncogenes in Human Colorectal Cancers With Microsatellite Instability

2013 ◽  
Vol 145 (3) ◽  
pp. 540-543.e22 ◽  
Author(s):  
Alexandra E. Gylfe ◽  
Johanna Kondelin ◽  
Mikko Turunen ◽  
Heikki Ristolainen ◽  
Riku Katainen ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Colorectal Cancers

scholarly journals Serrated Polyps and Serrated Polyposis Syndrome

2016 ◽  
Vol 29 (04) ◽  
pp. 336-344 ◽  
Author(s):  
Jean Ashburn ◽  
Thomas Plesec ◽  
Matthew Kalady
Keyword(s):  
Microsatellite Instability ◽  
Clinical Management ◽  
Promoter Hypermethylation ◽  
Colorectal Cancers ◽  
Polyposis Syndrome ◽  
Management Guidelines ◽  
Serrated Polyps

AbstractColorectal serrated polyps are intermediate lesions in the serrated neoplastic pathway, which account for up to 30% of colorectal cancers. This pathway is biologically distinct from the adenoma-to-carcinoma sequence, with associated cancers exhibiting mutations in the BRAF oncogene, DNA promoter hypermethylation, and microsatellite instability. An evolving understanding of these unique lesions has led to the development of a more accurate classification, improved endoscopic identification, and tailored clinical management guidelines. This article reviews serrated polyps and serrated polyposis syndrome.

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