Changes in the nature of P-glycoprotein gene transcripts during the development of multidrug resistance in CHO cells.

1995 ◽  
Vol 19 (1) ◽  
pp. 35-42 ◽  
Author(s):  
S Vickers
Keyword(s):  
Multidrug Resistance ◽  
Cho Cells ◽  
Glycoprotein Gene ◽  
P Glycoprotein ◽  
Gene Transcripts

scholarly journals Identification of members of the P-glycoprotein multigene family.

1989 ◽  
Vol 9 (3) ◽  
pp. 1224-1232 ◽  
Author(s):  
W F Ng ◽  
F Sarangi ◽  
R L Zastawny ◽  
L Veinot-Drebot ◽  
V Ling
Keyword(s):  
Multidrug Resistance ◽  
Gene Duplication ◽  
Gene Family ◽  
Multigene Family ◽  
Rhesus Monkeys ◽  
Genomic Library ◽  
Duplication Event ◽  
Glycoprotein Gene ◽  
P Glycoprotein ◽  
Exon Probe

Overproduction of P-glycoprotein is intimately associated with multidrug resistance. This protein appears to be encoded by a multigene family. Thus, differential expression of different members of this family may contribute to the complexity of the multidrug resistance phenotype. Three lambda genomic clones isolated from a hamster genomic library represent different members of the hamster P-glycoprotein gene family. Using a highly conserved exon probe, we found that the hamster P-glycoprotein gene family consists of three genes. We also found that the P-glycoprotein gene family consists of three genes in mice but has only two genes in humans and rhesus monkeys. The hamster P-glycoprotein genes have similar exon-intron organizations within the 3' region encoding the cytoplasmic domains. We propose that the hamster P-glycoprotein gene family arose from gene duplication. The hamster pgp1 and pgp2 genes appear to be more closely related to each other than either gene is to the pgp3 gene. We speculate that the hamster pgp1 and pgp2 genes arose from a recent gene duplication event and that primates did not undergo this duplication and therefore contain only two P-glycoprotein genes.

scholarly journals The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 ◽  
Vol 9 (3) ◽  
pp. 1346-1350 ◽  
Author(s):  
J M Croop ◽  
M Raymond ◽  
D Haber ◽  
A Devault ◽  
R J Arceci ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Multigene Family ◽  
Physiological Function ◽  
Rna Transcripts ◽  
P Glycoprotein ◽  
Mouse Tissues ◽  
Gene Transcripts ◽  
Normal Physiological Function ◽  
Rna Transcript ◽  
Mdr Genes

The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse. Expression levels of each mdr gene are dramatically different in various mouse tissues. Specific mdr RNA transcripts of approximately 4.5, 5, and 6 kilobases have been detected. Each of the mdr genes has a specific RNA transcript pattern. These results should be considered in relation to understanding the normal physiological function of the mdr multigene family.

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

1989 ◽  
Vol 9 (3) ◽  
pp. 1346-1350
Author(s):  
J M Croop ◽  
M Raymond ◽  
D Haber ◽  
A Devault ◽  
R J Arceci ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Multigene Family ◽  
Physiological Function ◽  
Rna Transcripts ◽  
P Glycoprotein ◽  
Mouse Tissues ◽  
Gene Transcripts ◽  
Normal Physiological Function ◽  
Rna Transcript ◽  
Mdr Genes

The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse. Expression levels of each mdr gene are dramatically different in various mouse tissues. Specific mdr RNA transcripts of approximately 4.5, 5, and 6 kilobases have been detected. Each of the mdr genes has a specific RNA transcript pattern. These results should be considered in relation to understanding the normal physiological function of the mdr multigene family.

Expression of multidrug resistance (P-glycoprotein) gene in liver cancers

1993 ◽  
Vol 8 (S1) ◽  
pp. S17-S20
Author(s):  
M. TIEN KUO ◽  
L. D. TEETER ◽  
S. CURLEY ◽  
H-C. HSU
Keyword(s):  
Multidrug Resistance ◽  
Glycoprotein Gene ◽  
P Glycoprotein ◽  
Liver Cancers

Identification of members of the P-glycoprotein multigene family

1989 ◽  
Vol 9 (3) ◽  
pp. 1224-1232
Author(s):  
W F Ng ◽  
F Sarangi ◽  
R L Zastawny ◽  
L Veinot-Drebot ◽  
V Ling
Keyword(s):  
Multidrug Resistance ◽  
Gene Duplication ◽  
Gene Family ◽  
Multigene Family ◽  
Rhesus Monkeys ◽  
Genomic Library ◽  
Duplication Event ◽  
Glycoprotein Gene ◽  
P Glycoprotein ◽  
Exon Probe

Overproduction of P-glycoprotein is intimately associated with multidrug resistance. This protein appears to be encoded by a multigene family. Thus, differential expression of different members of this family may contribute to the complexity of the multidrug resistance phenotype. Three lambda genomic clones isolated from a hamster genomic library represent different members of the hamster P-glycoprotein gene family. Using a highly conserved exon probe, we found that the hamster P-glycoprotein gene family consists of three genes. We also found that the P-glycoprotein gene family consists of three genes in mice but has only two genes in humans and rhesus monkeys. The hamster P-glycoprotein genes have similar exon-intron organizations within the 3' region encoding the cytoplasmic domains. We propose that the hamster P-glycoprotein gene family arose from gene duplication. The hamster pgp1 and pgp2 genes appear to be more closely related to each other than either gene is to the pgp3 gene. We speculate that the hamster pgp1 and pgp2 genes arose from a recent gene duplication event and that primates did not undergo this duplication and therefore contain only two P-glycoprotein genes.

A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene

Nature ◽  
10.1038/34669 ◽  
1998 ◽  
Vol 391 (6664) ◽  
pp. 291-295 ◽  
Author(s):  
Hendrik W. van Veen ◽  
Richard Callaghan ◽  
Loredana Soceneantu ◽  
Alessandro Sardini ◽  
Wil N. Konings ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Antibiotic Resistance Gene ◽  
Glycoprotein Gene ◽  
Bacterial Antibiotic Resistance ◽  
P Glycoprotein
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