INVOLVEMENT OF p38 AND JNK MAPKs PATHWAYS IN SUBSTANCE P-INDUCED PRODUCTION OF TNF-α BY PERITONEAL MAST CELLS

Cytokine ◽  
2002 ◽  
Vol 18 (2) ◽  
pp. 72-80 ◽  
Author(s):  
Antonina Azzolina ◽  
Patrizia Guarneri ◽  
Nadia Lampiasi
2003 ◽  
Vol 1643 (1-3) ◽  
pp. 75-83 ◽  
Author(s):  
Antonina Azzolina ◽  
Antonella Bongiovanni ◽  
Nadia Lampiasi

Cephalalgia ◽  
1997 ◽  
Vol 17 (3) ◽  
pp. 166-174 ◽  
Author(s):  
A Ottosson ◽  
L Edvinsson

The aim of the present study was to examine if the neuropeptides substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) can stimulate histamine release from mast cells in the dura mater and thereby play a role in cranial vasoregulation and local neurogenic inflammation. Dura mater mast cells were compared with peritoneal mast cells in the rat. Histamine was released from dura mater mast cells by compound 48/80, SP and CGRP but from peritoneal mast cells only by compound 8/80 and SP. NPY and VIP released quite small amounts of histamine from dural mast cells. The release on SP and CGRP from rat dura mater mast cells was blocked by the receptor antagonists FK888 and CGRP8-37 respectively, suggesting receptor mediated release mechanisms. None of the stimuli released histamine from human or porcine dural mast cells, possibly because the sampling procedure injures and incapacitates the cells.


1998 ◽  
Vol 117 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Yoshimichi Okayama ◽  
Yoshihiro Ono ◽  
Tsugio Nakazawa ◽  
Martin Church ◽  
Masatomo Mori
Keyword(s):  

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