scholarly journals Regulation of Transcriptional Activity during the First and Second Cell Cycles in the Preimplantation Mouse Embryo

1997 ◽  
Vol 181 (2) ◽  
pp. 296-307 ◽  
Author(s):  
Fugaku Aoki ◽  
Diane M. Worrad ◽  
Richard M. Schultz
Development ◽  
1984 ◽  
Vol 79 (1) ◽  
pp. 53-76
Author(s):  
H. Goodall ◽  
M. H. Johnson

The changing nature of intercellular coupling during the 4- and 8-cell stages of mouse early development has been investigated by iontophoretic injection of carboxyfluorescein, horse-radish peroxidase and current into individual blastomeres in either the intact embryo or after their disaggregation and reaggregation into pairs. Coupling junctions that allowed only molecules of low molecular weight (putative gap junctions) were found not to appear until 2–5 h beyond the 3rd cleavage division (8-cell stage). However, intercellular junctions that were not size selective were detected in intact embryos only throughout the 4- and 8-cell stages. It is proposed that this junctional communication results from the persistence of midbodies through all or part of the two, and in a few cases the three, cell cycles following their formation at the first and second cleavage divisions. We conclude that the cells of the early mouse embryo may be linked in a more extensive syncytial network than was hitherto suspected.


2014 ◽  
Author(s):  
Radu Zamfirescu ◽  
Salini Shreedharan ◽  
Mark Zada ◽  
Michael Morris ◽  
Margot L Day

1978 ◽  
Vol 67 (1) ◽  
pp. 214-224 ◽  
Author(s):  
Terry Magnuson ◽  
Janet B. Jacobson ◽  
Christopher W. Stackpole

Toxicology ◽  
1997 ◽  
Vol 116 (1-3) ◽  
pp. 123-131 ◽  
Author(s):  
Lynn A. Hanna ◽  
Jeffrey M. Peters ◽  
Lynn M. Wiley ◽  
Michael S. Clegg ◽  
Carl L. Keen

Nature ◽  
1976 ◽  
Vol 259 (5541) ◽  
pp. 319-321 ◽  
Author(s):  
JONATHAN VAN BLERKOM ◽  
SHEILA C. BARTON ◽  
MARTIN H. JOHNSON

2005 ◽  
Vol 11 (5) ◽  
pp. 615-619 ◽  
Author(s):  
Navid Esfandiari ◽  
Tommaso Falcone ◽  
Jeffrey M Goldberg ◽  
Ashok Agarwal ◽  
Rakesh K Sharma

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