μ- and δ-Opioid Receptor Antagonists Reduce Levodopa-Induced Dyskinesia in the MPTP-Lesioned Primate Model of Parkinson's Disease

2001 ◽  
Vol 171 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Brian Henry ◽  
Susan H. Fox ◽  
Alan R. Crossman ◽  
Jonathan M. Brotchie
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Opioid Receptor ◽  
Receptor Antagonists ◽  
Primate Model ◽  
Opioid Receptor Antagonists ◽  
Δ Opioid Receptor

Involvement of δ1-opioid receptor antagonism in the antitussive effect of δ-opioid receptor antagonists

1994 ◽  
Vol 251 (2-3) ◽  
pp. 291-294 ◽  
Author(s):  
Junzo Kamei ◽  
Yuriko Iwamoto ◽  
Tsutomu Suzuki ◽  
Miwa Misawa ◽  
Hiroshi Nagase ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Antagonists ◽  
Receptor Antagonism ◽  
Antitussive Effect ◽  
Opioid Receptor Antagonists ◽  
Δ Opioid Receptor

scholarly journals Interactive Responses of Enkephalin, δ-opioid Receptor and Dopamine Receptor D1/D2 to Hypoxia and/or MPP+ Stress in PC12 Cells

2021 ◽  
Author(s):  
Tao Chen ◽  
Qing-Yu Wang ◽  
Dong-Man Chao ◽  
Yi-Dong Deng ◽  
Yan-Hui Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Receptor ◽  
Pc12 Cells ◽  
Opioid Receptor ◽  
Mrna Level ◽  
Cell Protection ◽  
Endogenous Opioid ◽  
Δ Opioid Receptor

Abstract Hypoxic/ischemic brain injury is a potential etiology of Parkinson’s disease (PD). There is evidence suggesting that the up-regulation of enkephalin, an endogenous opioid, in the midbrain may have a compensatory effect against Parkinson’s disease (PD) related motor symptoms. To explore the potential mechanism underlying this action, we investigated the effects of hypoxia and MPP+, a pathological inducer PD, on enkephalin, δ-opioid receptor (DOR, an enkephalin receptor), and prohormone convertases 1 and 2 (PC1/PC2) on in- vitro PD model of PC12 cells. We found that (1) short-term hypoxia could inducing cell protection by up-regulating the level of enkephalin, accompanied by the synergistic up-regulation of δ-opioid receptor (DOR) ; (2) a longer period of hypoxia or MPP+ insult accelerated the proteolysis of proenkephalin by up-regulating PC1/PC2 which might produce more active enkephalin and thus activating DOR for cell protection; (3) The levels of enkephalin and DOR decreased significantly after a prolonged hypoxia or MPP+ insult; and (4) a certain degree of hypoxia improved cell viability and enhance the transcription of dopamine D1/D2 receptorby increasing their mRNA level. Our findings suggest that hypoxia may induce an interactive reaction of enkephalin, DOR and dopamine receptor D1/D2, which is potentially beneficial for cell surviving to severe/prolonged hypoxia and PD condition.

δ-Opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine

1993 ◽  
Vol 249 (2) ◽  
pp. 167-177 ◽  
Author(s):  
Declan N.C. Jones ◽  
Wayne D. Bowen ◽  
Philip S. Portoghese ◽  
Stephen G. Holtzman
Keyword(s):  
Motor Activity ◽  
Opioid Receptor ◽  
Receptor Antagonists ◽  
Opioid Receptor Antagonists ◽  
Δ Opioid Receptor

μ- and δ-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence

1996 ◽  
Vol 21 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Y. Z. Feng ◽  
T. Zhang ◽  
S. Tokuyama ◽  
H. Zhu ◽  
R. W. Rockhold ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Morphine Dependence ◽  
Receptor Antagonists ◽  
Opioid Receptor Antagonists ◽  
Δ Opioid Receptor
Sign in / Sign up

Export Citation Format

Share Document