scholarly journals Use of the Ornithine Decarboxylase Promoter to Achieve N-MYC-Mediated Overexpression of a Rabbit Carboxylesterase to Sensitize Neuroblastoma Cells to CPT-11

2000 ◽  
Vol 1 (5) ◽  
pp. 457-463 ◽  
Author(s):  
Cynthia A. Pawlik ◽  
Rekha V. Iyengar ◽  
Erik J. Krull ◽  
Stephen E. Mason ◽  
Ruchi Khanna ◽  
...  
Keyword(s):  
Ornithine Decarboxylase ◽  
Neuroblastoma Cells

Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells

2020 ◽  
Vol 83 (8) ◽  
pp. 2518-2527 ◽  
Author(s):  
Chad R. Schultz ◽  
Martin C. H. Gruhlke ◽  
Alan J. Slusarenko ◽  
André S. Bachmann
Keyword(s):  
Ornithine Decarboxylase ◽  
Neuroblastoma Cells ◽  
Decarboxylase Inhibitor

Effect of GABA and isogabaculine on ornithine decarboxylase and putrescine metabolism

1982 ◽  
Vol 243 (1) ◽  
pp. C35-C38 ◽  
Author(s):  
K. A. Diekema ◽  
P. P. McCann ◽  
B. J. Lippert
Keyword(s):  
Ornithine Decarboxylase ◽  
Neuroblastoma Cells ◽  
Appreciable Amount ◽  
Gamma Aminobutyric Acid ◽  
Irreversible Inhibitor ◽  
Gaba Transaminase ◽  
Rat Glioma ◽  
Glioma C6 ◽  
Metabolic Route ◽  
Htc Cells

Isogabaculine (3-amino-1,3-cyclohexadienyl carboxylic acid; RMI 71,932), an irreversible inhibitor of GABA transaminase, when added to mouse neuroblastoma cells in spinner culture at the time of induction of cell proliferation, increased ornithine decarboxylase (ODC) activity threefold above that of normal control cells and twofold above that of GABA (gamma-aminobutyric acid)-treated cells. Isogabaculine did not affect ODC activity of rat glioma (C6) or rat hepatoma (HTC) cells. As determined by half-life measurements of ODC and intracellular GABA concentrations, isogabaculine apparently has a direct stabilizing effect on ODC in neuroblastoma cells that is unrelated to the accumulation of GABA due to GABA transaminase inhibition. Putrescine metabolism to GABA or spermidine was determined in C6, HTC, and neuroblastoma cells in the presence or absence of isogabaculine and/or GABA. Neither GABA nor isogabaculine treatment dramatically altered the metabolism of putrescine to GABA or spermidine in neuroblastoma, C6 glioma, or HTC cells. However, the appreciable amount of labeled GABA formed from putrescine indicated that this metabolic route may be more important than was previously thought.

Ornithine decarboxylase activity and the growth of neuroblastoma cells

1978 ◽  
Vol 27 (5) ◽  
pp. 717-721 ◽  
Author(s):  
Sharon K. Chapman ◽  
Marilyn Martin ◽  
Michael S. Hoover ◽  
Chung Y. Chiou
Keyword(s):  
Ornithine Decarboxylase ◽  
Neuroblastoma Cells ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity

Effects of exposure to DAMPS and GSM signals on Ornithine Decarboxylase (ODC) activity: II. SH-SY5Y human neuroblastoma cells

2009 ◽  
Vol 85 (6) ◽  
pp. 519-522 ◽  
Author(s):  
Bernard Billaudel ◽  
Murielle Taxile ◽  
Florence Poulletier de Gannes ◽  
Gilles Ruffie ◽  
Isabelle Lagroye ◽  
...  
Keyword(s):  
Ornithine Decarboxylase ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma
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