Roles of NADPH-P450 Reductase and Apo- and Holo-Cytochrome b5 on Xenobiotic Oxidations Catalyzed by 12 Recombinant Human Cytochrome P450s Expressed in Membranes of Escherichia coli

Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli

Journal of Industrial Microbiology & Biotechnology ◽

10.1007/s10295-004-0202-1 ◽

2005 ◽

Vol 32 (2) ◽

pp. 67-74 ◽

Cited By ~ 77

Author(s):

Robert B. Vail ◽

Michael J. Homann ◽

Imad Hanna ◽

Aleksey Zaks

Keyword(s):

Escherichia Coli ◽

Cytochrome P450s ◽

Preparative Synthesis ◽

Drug Metabolites ◽

P450 Reductase ◽

Roles of NADPH-P450 Reductase in the O-Deethylation of 7-Ethoxycoumarin by Recombinant Human Cytochrome P450 1B1 Variants in Escherichia coli

Protein Expression and Purification ◽

10.1006/prep.2000.1302 ◽

2000 ◽

Vol 20 (1) ◽

pp. 73-80 ◽

Cited By ~ 13

Author(s):

Tsutomu Shimada ◽

Fujiko Tsumura ◽

Elizabeth M.J. Gillam ◽

F.Peter Guengerich ◽

Kiyoshi Inoue

Keyword(s):

Escherichia Coli ◽

Cytochrome P450 ◽

Cytochrome P450 1B1 ◽

P450 Reductase ◽

Development of a high-throughput genotoxicity assay using Umu test strains expressing human cytochrome P450s and NADPH-P450 reductase and bacterial O -acetyltransferase

Environmental and Molecular Mutagenesis ◽

10.1002/em.22092 ◽

2017 ◽

Vol 58 (4) ◽

pp. 209-216 ◽

Cited By ~ 1

Author(s):

Hisako Hori ◽

Daisuke Hirata ◽

Wataru Fujii ◽

Yoshimitsu Oda

Keyword(s):

High Throughput ◽

Cytochrome P450s ◽

P450 Reductase ◽

Umu Test ◽

Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies

Mutation Research/Genetic Toxicology and Environmental Mutagenesis ◽

10.1016/s1383-5718(99)00032-7 ◽

1999 ◽

Vol 441 (1) ◽

pp. 73-83 ◽

Cited By ~ 24

Author(s):

Michel Kranendonk ◽

Filipa Carreira ◽

Patricia Theisen ◽

Antonio Laires ◽

Charles W Fisher ◽

...

Keyword(s):

Escherichia Coli ◽

Cytochrome P450 ◽

Catalytic Activities ◽

P450 Reductase ◽

Human Cytochrome ◽

Cytochrome P450 Isoforms

Co-expression of human cytochrome b5 increases expression of cytochrome P450 3A4 in Escherichia coli by stabilizing mRNA

Protein Expression and Purification ◽

10.1016/j.pep.2013.02.010 ◽

2013 ◽

Vol 89 (1) ◽

pp. 44-50 ◽

Cited By ~ 5

Author(s):

Mi-Sook Dong ◽

Sang-Bum Lee ◽

Hyun-Jung Kim

Keyword(s):

Escherichia Coli ◽

Cytochrome P450 ◽

Cytochrome B5 ◽

Cytochrome P450 3A4 ◽

Co-expressing house fly cytochrome P450 6A1 and human cytochrome P450 reductase in Escherichia coli to bioconvert insecticide aldrin

AFRICAN JOURNAL OF BIOTECHNOLOGY ◽

10.5897/ajb2018.16502 ◽

2018 ◽

Vol 17 (33) ◽

pp. 1031-1039

Author(s):

Wu Yating ◽

Li Yong ◽

Liang Xiaosheng ◽

Jiang Nan ◽

Wu Yunhua

Keyword(s):

Escherichia Coli ◽

Cytochrome P450 ◽

House Fly ◽

P450 Reductase ◽

Reconstitution of the Enzymatic Activities of Cytochrome P450s Using Recombinant Flavocytochromes Containing Rat Cytochrome b5 Fused to NADPH–Cytochrome P450 Reductase with Various Membrane-Binding Segments

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.2001.2372 ◽

2001 ◽

Vol 390 (2) ◽

pp. 215-221 ◽

Cited By ~ 15

Author(s):

Andrei A. Gilep ◽

Oleg L. Guryev ◽

Sergey A. Usanov ◽

Ronald W. Estabrook

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Membrane Binding ◽

Cytochrome P450s ◽

Enzymatic Activities ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

Coexpression of Genetically Engineered Fused Enzyme between Yeast NADPH–P450 Reductase and Human Cytochrome P450 3A4 and Human Cytochrome b5 in Yeast

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.2000.1953 ◽

2000 ◽

Vol 381 (1) ◽

pp. 164-170 ◽

Cited By ~ 22

Author(s):

Koji Hayashi ◽

Toshiyuki Sakaki ◽

Shiro Kominami ◽

Kuniyo Inouye ◽

Yoshiyasu Yabusaki

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Genetically Engineered ◽

Cytochrome P450 3A4 ◽

P450 Reductase ◽

Biphasic effects of the flavonoids quercetin and naringenin on the metabolic activation of 2-amino-3,5-dimethylimidazo[4,5-f]quinoline by Salmonella typhimurium TA1538 co-expressing human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and cytochrome b5

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/j.mrfmmm.2003.08.002 ◽

2004 ◽

Vol 545 (1-2) ◽

pp. 37-47 ◽

Cited By ~ 21

Author(s):

I Kang

Keyword(s):

Cytochrome P450 ◽

Salmonella Typhimurium ◽

Cytochrome B5 ◽

Metabolic Activation ◽

Cytochrome P450 1A2 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Human Cytochrome ◽

Nadph Cytochrome P450 Reductase

Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: Comparison of three types of expression systems

Mutation Research/Genetic Toxicology and Environmental Mutagenesis ◽

10.1016/s1383-5718(98)00193-4 ◽

1999 ◽

Vol 439 (2) ◽

pp. 287-300 ◽

Cited By ~ 19

Author(s):

Michel Kranendonk ◽

Charles W Fisher ◽

Rita Roda ◽

Filipa Carreira ◽

Patricia Theisen ◽

...

Keyword(s):

Escherichia Coli ◽

Cytochrome P450 ◽

Expression Systems ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Human Cytochrome ◽

Nadph Cytochrome P450 Reductase