Exploration of the Active Site of Dipeptidyl Peptidase IV From Porphyromonas gingivalis

2004 ◽  
pp. 29-35 ◽  
Author(s):  
Anne-Marie Lambeir ◽  
Dean Rea ◽  
Vilmos Fülö ◽  
Yumi Kumagai ◽  
Koen Augustyns ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Active Site ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv

scholarly journals Crystal Structures of HIV-1 Tat-derived Nonapeptides Tat-(1–9) and Trp2-Tat-(1–9) Bound to the Active Site of Dipeptidyl-peptidase IV (CD26)

2005 ◽  
Vol 280 (15) ◽  
pp. 14911-14917 ◽  
Author(s):  
Wilhelm Andreas Weihofen ◽  
Jianguo Liu ◽  
Werner Reutter ◽  
Wolfram Saenger ◽  
Hua Fan
Keyword(s):  
Crystal Structures ◽  
Active Site ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Hiv 1

A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site

2013 ◽  
Vol 434 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Mika Nabeno ◽  
Fumihiko Akahoshi ◽  
Hiroyuki Kishida ◽  
Ikuko Miyaguchi ◽  
Yoshihito Tanaka ◽  
...  
Keyword(s):  
Comparative Study ◽  
Active Site ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Binding Modes ◽  
Dipeptidyl Peptidase Iv Inhibitors

Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site

2007 ◽  
Vol 17 (6) ◽  
pp. 1765-1768 ◽  
Author(s):  
Scott M. Sheehan ◽  
Hans-Juergen Mest ◽  
Brian M. Watson ◽  
Valentine J. Klimkowski ◽  
David E. Timm ◽  
...  
Keyword(s):  
Conformational Change ◽  
Active Site ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Dipeptidyl Peptidase Iv Inhibitors

An active-site mutation (Gly633 .fwdarw. Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum

Biochemistry ◽  
1992 ◽  
Vol 31 (47) ◽  
pp. 11921-11927 ◽  
Author(s):  
Emiko Tsuji ◽  
Yoshio Misumi ◽  
Toshiyuki Fujiwara ◽  
Noboru Takami ◽  
Shigenori Ogata ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Active Site ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Site Mutation ◽  
Rapid Degradation

Identification of the active site residues in dipeptidyl peptidase IV by affinity labeling and site-directed mutagenesis

Biochemistry ◽  
1992 ◽  
Vol 31 (9) ◽  
pp. 2582-2587 ◽  
Author(s):  
Shigenori Ogata ◽  
Yoshio Misumi ◽  
Emiko Tsuji ◽  
Noboru Takami ◽  
Kimimitsu Oda ◽  
...  
Keyword(s):  
Active Site ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Site Directed Mutagenesis ◽  
Affinity Labeling ◽  
Directed Mutagenesis ◽  
Active Site Residues

Sequence analysis of the Porphyromonas gingivalis dipeptidyl peptidase IV gene

1998 ◽  
Vol 1396 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Michiko Kiyama ◽  
Mitsuo Hayakawa ◽  
Teruaki Shiroza ◽  
Shoji Nakamura ◽  
Akira Takeuchi ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Porphyromonas Gingivalis ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv

CoMFA and CoMSIA of diverse pyrrolidine analogues as dipeptidyl peptidase IV inhibitors: active site requirements

2010 ◽  
Vol 15 (2) ◽  
pp. 457-466 ◽  
Author(s):  
Vanangamudi Murugesan ◽  
Nidhi Sethi ◽  
Yenamandra S. Prabhakar ◽  
Seturam B. Katti
Keyword(s):  
Active Site ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Dipeptidyl Peptidase Iv Inhibitors
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