scholarly journals Functional Classification of G-Protein Coupled Receptors, Based on Their Specific Ligand Coupling Patterns

2006 ◽  
pp. 1-12 ◽  
Author(s):  
Burcu Bakir ◽  
Osman Ugur Sezerman
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Functional Classification ◽  
G Protein Coupled ◽  
Specific Ligand

A Multiple Classifier System for Functional Classification of G Protein-Coupled Receptors

2010 ◽  
Vol 171-172 ◽  
pp. 403-407
Author(s):  
Yi Nan Lu ◽  
Yong Quan ◽  
Dan Mei Huang
Keyword(s):  
G Protein ◽  
Drug Targets ◽  
Protein Structures ◽  
Fusion Rule ◽  
G Protein Coupled Receptors ◽  
Functional Classification ◽  
Classifier System ◽  
Multiple Classifier ◽  
G Protein Coupled

G protein-coupled receptors (GPCRs) are the largest protein super family in the human body and play a significant role in the pharmaceutical industry as drug targets. Although the deep research in GPCRs is continuing to grow, the study on their structures and functions is limited, for it is difficult and complex for the researchers to obtain purified membrane protein structures of GPCRs. Currently, how to get the structures of GPCRs and how to analyze them are the most important issues in modern molecular biology and medicine. We adopted multi-classifier method to deal with the problem of functional classification of GPCRs. Based on class hierarchy, the different data sets for training the classifiers were formed, and the diversity and accuracy were considered together in selecting the classifier sets. The dynamic weighted fusion rule was used to combine the classifiers. Experimental results show the effectiveness of this multi-classifier system.

Alignment-Free Classification of G-Protein-Coupled Receptors Using Self-Organizing Maps

2006 ◽  
Vol 46 (3) ◽  
pp. 1479-1490 ◽  
Author(s):  
Joji M. Otaki ◽  
Akihito Mori ◽  
Yoshimasa Itoh ◽  
Takashi Nakayama ◽  
Haruhiko Yamamoto
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Self Organizing Maps ◽  
Alignment Free ◽  
Free Classification ◽  
G Protein Coupled ◽  
Self Organizing
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