SIGLEC-4 (MAG) Antagonists: From the Natural Carbohydrate Epitope to Glycomimetics

2013 ◽  
pp. 151-200 ◽  
Author(s):  
Oliver Schwardt ◽  
Soerge Kelm ◽  
Beat Ernst
Keyword(s):  
Carbohydrate Epitope

Developmental expression of the HNK-1 carbohydrate epitope on aggrecan during chondrogenesis

2002 ◽  
Vol 226 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Miriam S. Domowicz ◽  
Melissa M. Mueller ◽  
Todd E. Novak ◽  
Lauren E. Schwartz ◽  
Nancy B. Schwartz
Keyword(s):  
Developmental Expression ◽  
Carbohydrate Epitope

scholarly journals Identification of a peptide mimic of the L2/HNK-1 carbohydrate epitope

2002 ◽  
Vol 83 (6) ◽  
pp. 1380-1388 ◽  
Author(s):  
Maryline Simon-Haldi ◽  
Ned Mantei ◽  
Jens Franke ◽  
Hans Voshol ◽  
Melitta Schachner
Keyword(s):  
Carbohydrate Epitope ◽  
Peptide Mimic

Mutants of Polysphondylium pallidum showing delayed modifications of glycoproteins are altered in a regulatory signal for development

1987 ◽  
Vol 87 (1) ◽  
pp. 121-132
Author(s):  
K. Toda ◽  
D. Francis ◽  
G. Gerisch
Keyword(s):  
Monoclonal Antibody ◽  
Early Stage ◽  
Developmental Regulation ◽  
Cell Aggregation ◽  
Carbohydrate Structure ◽  
Wild Type ◽  
Polysphondylium Pallidum ◽  
Carbohydrate Epitope ◽  
Regulatory Signal ◽  
Cell Surface Glycoproteins

Binding of a monoclonal antibody, mAb293, to cell-surface glycoproteins of Polysphondylium pallidum is known to be blocked by L-fucose, and Fab of this antibody has been shown to inhibit intercellular adhesion of aggregation-competent cells. Mutants with delayed expression of the carbohydrate epitope, ep293, recognized by the antibody, have been shown to be retarded and altered in cell aggregation. The present study shows that ep293 is a modification of carbohydrate structure that is subject to regulation not only in mutant but also in wild-type cells; ep293 is expressed at an early stage of exponential growth in wild-type and only after 12 h of starvation in mutant PN6002. Proteins are already glycosylated before the epitope is expressed. The developmental regulation of pallidin, a lectin known to be an unglycosylated protein, was investigated in parallel with ep293 using a monoclonal antibody. Pallidin was expressed at about the same time as the carbohydrate epitope in cells of the wild-type as well as the mutant. These results indicate a regulatory signal to which various events are coupled. Induction of ep293 and expression of pallidin are two of these events, and mutants such as PN6002 are altered in the timing of the signal.

scholarly journals A sulfated carbohydrate epitope inhibits axon regeneration after injury

2012 ◽  
Vol 109 (13) ◽  
pp. 4768-4773 ◽  
Author(s):  
J. M. Brown ◽  
J. Xia ◽  
B. Zhuang ◽  
K.-S. Cho ◽  
C. J. Rogers ◽  
...  
Keyword(s):  
Axon Regeneration ◽  
Carbohydrate Epitope ◽  
Sulfated Carbohydrate

Gold Nanoparticles Coated with Oligomannosides of HIV-1 Glycoprotein gp120 Mimic the Carbohydrate Epitope of Antibody 2G12

2011 ◽  
Vol 410 (5) ◽  
pp. 798-810 ◽  
Author(s):  
Marco Marradi ◽  
Paolo Di Gianvincenzo ◽  
Pedro M. Enríquez-Navas ◽  
Olga M. Martínez-Ávila ◽  
Fabrizio Chiodo ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Carbohydrate Epitope ◽  
Glycoprotein Gp120 ◽  
Hiv 1 ◽  
Antibody 2G12

A male genital tract-specific carbohydrate epitope on human CD52: Implications for immunocontraception

2002 ◽  
Vol 60 (5) ◽  
pp. 354-364 ◽  
Author(s):  
E.J. Norton ◽  
A.B. Diekman ◽  
V.A. Westbrook ◽  
D.W. Mullins ◽  
K.L. Klotz ◽  
...  
Keyword(s):  
Genital Tract ◽  
Male Genital Tract ◽  
Carbohydrate Epitope ◽  
Male Genital

Major glycoproteins in carp CNS myelin: Homology to P0 protein with HNK-1/L2 carbohydrate epitope

1993 ◽  
Vol 23 (3) ◽  
pp. 239-248 ◽  
Author(s):  
Kohtaro Takei ◽  
Kunio Kitamura ◽  
Koji Banno ◽  
Keiichi Uyemura
Keyword(s):  
Carbohydrate Epitope ◽  
P0 Protein

scholarly journals Dual Action of a Carbohydrate Epitope on Afferent and Efferent Axons in Cortical Development

1996 ◽  
Vol 16 (13) ◽  
pp. 4195-4206 ◽  
Author(s):  
Sigrid Henke-Fahle ◽  
Fanny Mann ◽  
Magdalena Götz ◽  
Karen Wild ◽  
Jürgen Bolz
Keyword(s):  
Cortical Development ◽  
Carbohydrate Epitope ◽  
Dual Action
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