Trapping of Reactive Intermediates to Study Reaction Mechanisms in Cellulose Chemistry

2006 ◽  
pp. 153-197 ◽  
Author(s):  
Thomas Rosenau ◽  
Antje Potthast ◽  
Paul Kosma
Keyword(s):  
Reaction Mechanisms ◽  
Reactive Intermediates

scholarly journals Pathways of Non-enzymatic Lysine Acylation

2021 ◽  
Vol 9 ◽  
Author(s):  
Tim Baldensperger ◽  
Marcus A. Glomb
Keyword(s):  
Molecular Mechanism ◽  
Reaction Mechanisms ◽  
Protein Modification ◽  
Environmental Changes ◽  
Reactive Intermediates ◽  
Protein Homeostasis ◽  
Metabolic Processes ◽  
Cellular Regulation ◽  
Regulatory Processes ◽  
Posttranslational Protein Modification

Posttranslational protein modification by lysine acylation is an emerging mechanism of cellular regulation and fine-tunes metabolic processes to environmental changes. In this review we focus on recently discovered pathways of non-enzymatic lysine acylation by reactive acyl-CoA species, acyl phosphates, and α-dicarbonyls. We summarize the metabolic sources of these highly reactive intermediates, demonstrate their reaction mechanisms, give an overview of the resulting acyl lysine modifications, and evaluate the consequences for cellular regulatory processes. Finally, we discuss interferences between lysine acylation and lysine ubiquitylation as a potential molecular mechanism of dysregulated protein homeostasis in aging and related diseases.

Interplay of synthesis and mechanism in asymmetric homogeneous catalysis

2001 ◽  
Vol 73 (2) ◽  
pp. 343-346 ◽  
Author(s):  
Nicholas J. Adams ◽  
Joachim Bargon ◽  
John M. Brown ◽  
Edward J. Farrington ◽  
Erwan Galardon ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Homogeneous Catalysis ◽  
Reaction Mechanisms ◽  
Palladium Catalysts ◽  
Reactive Intermediates ◽  
Intimate Relationship ◽  
Late Transition Metals ◽  
Ligand Structure ◽  
Late Transition ◽  
Asymmetric Homogeneous Catalysis

Asymmetric homogeneous catalysis forms one of the main planks of modern organic synthesis. It has developed rapidly and largely through the application of novel ligands, whose design is very much based on insight and intuition. At the same time, a better understanding of catalytic reaction mechanisms can contribute to further progress, since it can identify the intimate relationship between ligand structure and successful applications. The presentation will concentrate on the author's research with complexes of the late transition metals and include the search for superior methodologies in hydroboration, as well as ventures into the chemistry of reactive intermediates. The latter will be exemplified from work with rhodium and palladium catalysts.

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