Acute Adverse Reactions to Gadolinium-Based Contrast Media

2014 ◽  
pp. 201-206 ◽  
Author(s):  
Henrik S. Thomsen ◽  
Georg M. Bongartz
Keyword(s):  
Contrast Media ◽  
Adverse Reactions

Adverse Drug Reactions to Radiographic Contrast Media in a Teaching Hospital in North India: An Observational Study

2019 ◽  
Vol 14 (2) ◽  
pp. 122-126
Author(s):  
Deepti Chopra ◽  
Abhinav Jain ◽  
Richa Garg ◽  
Shreya Dhingra
Keyword(s):  
Observational Study ◽  
Contrast Media ◽  
Adverse Drug Reactions ◽  
Teaching Hospital ◽  
Adverse Reactions ◽  
North India ◽  
Drug Reactions ◽  
Iodinated Contrast ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

Background: Radiocontrast media are used extensively nowadays to visualize internal organs. Currently, non-ionic iodinated contrast media are used which are generally considered to be safe but some adverse reactions have been reported. Thus, the present study was carried out to analyze the nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching hospital. Methods:An observational study carried out for a period of six months in a teaching hospital. Contrast media induced adverse reactions were analyzed in terms of affected organs, rate, causality assessment, severity and preventability. The treatment and outcomes of adverse events were also recorded. Naranjo Probability Scale was used to evaluate the relationship between the contrast agent used and the suspected ADR. The severity of the suspected ADRs was determined using Hartwig Scale and preventability was assessed using modified Schumock and Thornton criterion. Results:A total of 15 suspected ADRs occurred in 11 patients with an incidence of 1.4%. It included 5 (45.4%) males and 6 (54.5%) females (p < 05). The highest percentage (72.7 %) of ADRs was seen in adult patients, the mean age being 40.8 years. Vomiting (33.3%) was the most common ADR noted followed by severe nausea and rashes. 64.7 % of ADRs were categorized as probable and 35.3 % were possible. Adverse reactions required treatment in 46.6% patients. There was no fatality reported. Conclusion:The reactions observed were mild to moderate in severity and occurred within 30 minutes of the administration of the contrast.

scholarly journals T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab

2021 ◽  
Vol 9 (5) ◽  
pp. e002521
Author(s):  
Sean Hammond ◽  
Anna Olsson-Brown ◽  
Joshua Gardner ◽  
Paul Thomson ◽  
Serat-E Ali ◽  
...  
Keyword(s):  
Contrast Media ◽  
Adverse Reactions ◽  
Stevens Johnson Syndrome ◽  
Iodinated Contrast ◽  
Immune Mediated ◽  
Johnson Syndrome ◽  
Healthy Donors ◽  
Concomitant Medications

Many adverse reactions associated with immune checkpoint inhibitor (ICI) treatments are immunologically driven and may necessitate discontinuation of the ICI. Herein, we present a patient who had been administered the radio contrast media amidotrizoate multiple times without issue but who then developed a Stevens-Johnson syndrome reaction after coadministration of atezolizumab. Causality was confirmed by a positive re-challenge with amidotrizoate and laboratory investigations that implicated T cells. Importantly, the introduction of atezolizumab appears to have altered the immunologic response to amidotrizoate in terms of the tolerance–elicitation continuum. Proof of concept studies demonstrated enhancement of recall responses to a surrogate antigen panel following in-vitro (healthy donors) and in-vivo (ICI patients) administrations of ICIs. Our findings highlight the importance of considering all concomitant medications in patients on ICIs who develop immune-mediated adverse reactions. In the event of some immune-related adverse reactions, it may be critical to identify the culprit antigen-forming entity that the ICIs have altered the perception of rather than simply attribute causality to the ICI itself in order to optimize both patient safety and treatment of malignancies.

Immunologic Basis for Adverse Reactions to Radiographic Contrast Media

1990 ◽  
Vol 31 (6) ◽  
pp. 605-612 ◽  
Author(s):  
V. Stejskal ◽  
R. Nilsson ◽  
A. Grepe
Keyword(s):  
Contrast Media ◽  
Adverse Reactions ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

scholarly journals A Clinical Study of Cutaneous Adverse Reactions to Nonionic Contrast Media in Korea

2012 ◽  
Vol 24 (1) ◽  
pp. 22 ◽  
Author(s):  
Kyung Eun Jung ◽  
Jimin Chung ◽  
Byung Cheol Park ◽  
Keum Nahn Jee ◽  
Young Koo Jee ◽  
...  
Keyword(s):  
Clinical Study ◽  
Contrast Media ◽  
Adverse Reactions ◽  
Nonionic Contrast Media ◽  
Cutaneous Adverse Reactions

Breakthrough Adverse Reactions to Low-Osmolar Contrast Media After Steroid Premedication

2001 ◽  
Vol 176 (6) ◽  
pp. 1389-1392 ◽  
Author(s):  
Kelly S. Freed ◽  
Richard A. Leder ◽  
Cindy Alexander ◽  
David M. DeLong ◽  
Mark A. Kliewer
Keyword(s):  
Contrast Media ◽  
Adverse Reactions

scholarly journals Adverse reactions of low osmolality contrast media during cardiac angiography: A prospective randomized multicenter study

1992 ◽  
Vol 19 (5) ◽  
pp. 899-906 ◽  
Author(s):  
Edward W. Gertz ◽  
Judith A. Wisneski ◽  
Robert Miller ◽  
Merrill Knudtson ◽  
John Robb ◽  
...  
Keyword(s):  
Contrast Media ◽  
Multicenter Study ◽  
Adverse Reactions ◽  
Cardiac Angiography

Adverse Reactions of Low Osmolar Non-Ionic and Ionic Contrast Media When Used Together or Separately During Percutaneous Coronary Intervention

2005 ◽  
Vol 14 (3) ◽  
pp. 172-177 ◽  
Author(s):  
Craig P. Juergens ◽  
Aye Mi Khaing ◽  
Geraldine J. McIntyre ◽  
Dominic Y.C. Leung ◽  
Sidney T.H. Lo ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Contrast Media ◽  
Adverse Reactions ◽  
Coronary Intervention ◽  
Ionic Contrast ◽  
Percutaneous Coronary

The Lalli and Weber effects and the incidence of acute non-renal adverse reactions to contrast media

2012 ◽  
Vol 53 (9) ◽  
pp. 953-954 ◽  
Author(s):  
Henrik S Thomsen ◽  
Judith Webb
Keyword(s):  
Contrast Media ◽  
Adverse Reactions
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