Methods for Analysis of Keratinocyte Migration

2019 ◽  
pp. 219-224
Author(s):  
Jie Liu ◽  
Jiaping Zhang
Keyword(s):  
Keratinocyte Migration

MMP-14 mediated MMP-9 expression is involved in TGF-beta1-induced keratinocyte migration

2008 ◽  
Vol 104 (3) ◽  
pp. 934-941 ◽  
Author(s):  
Young Seomun ◽  
Jong-Tak Kim ◽  
Choun-Ki Joo
Keyword(s):  
Keratinocyte Migration

Leucine-rich glioma inactivated 3 promotes HaCaT keratinocyte migration

2013 ◽  
Vol 21 (4) ◽  
pp. 634-640 ◽  
Author(s):  
Yun-Mi Jeong ◽  
Woo-Jae Park ◽  
Myo-Kyoung Kim ◽  
Kwang Jin Baek ◽  
Nyoun Soo Kwon ◽  
...  
Keyword(s):  
Keratinocyte Migration ◽  
Hacat Keratinocyte

Mechanism of hydrogen peroxide-induced keratinocyte migration in a scratch-wound model

2011 ◽  
Vol 51 (4) ◽  
pp. 884-892 ◽  
Author(s):  
Alvin Eng Kiat Loo ◽  
Rongjian Ho ◽  
Barry Halliwell
Keyword(s):  
Hydrogen Peroxide ◽  
Keratinocyte Migration ◽  
Wound Model ◽  
Scratch Wound

scholarly journals The p38-MAPK/SAPK Pathway is Required for Human Keratinocyte Migration on Dermal Collagen

2001 ◽  
Vol 117 (6) ◽  
pp. 1601-1611 ◽  
Author(s):  
Wei Li ◽  
Celina Nadelman ◽  
Ginard Henry ◽  
Jianhua Fan ◽  
Matt Muellenhoff ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Keratinocyte Migration ◽  
Human Keratinocyte ◽  
Dermal Collagen

Syndecan-1 interaction with the LG4/5 domain in laminin-332 is essential for keratinocyte migration

2007 ◽  
Vol 214 (1) ◽  
pp. 238-249 ◽  
Author(s):  
Sophie Bachy ◽  
François Letourneur ◽  
Patricia Rousselle
Keyword(s):  
Keratinocyte Migration ◽  
Laminin 332

scholarly journals EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis

2017 ◽  
Vol 214 (10) ◽  
pp. 2889-2900 ◽  
Author(s):  
Gopinath M. Sundaram ◽  
Hisyam M. Ismail ◽  
Mohsin Bashir ◽  
Manish Muhuri ◽  
Candida Vaz ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Prognostic Significance ◽  
Competitive Inhibitor ◽  
Molecular Switch ◽  
Extracellular Signal Regulated Kinase ◽  
Keratinocyte Migration ◽  
Extracellular Signal ◽  
Single Transcript ◽  
Kinase Phosphorylation

Epithelial carcinomas are well known to activate a prolonged wound-healing program that promotes malignant transformation. Wound closure requires the activation of keratinocyte migration via a dual-state molecular switch. This switch involves production of either the anti-migratory microRNA miR-198 or the pro-migratory follistatin-like 1 (FSTL1) protein from a single transcript; miR-198 expression in healthy skin is down-regulated in favor of FSTL1 upon wounding, which enhances keratinocyte migration and promotes re-epithelialization. Here, we reveal a defective molecular switch in head and neck squamous cell carcinoma (HNSCC). This defect shuts off miR-198 expression in favor of sustained FSTL1 translation, driving metastasis through dual parallel pathways involving DIAPH1 and FSTL1. DIAPH1, a miR-198 target, enhances directional migration through sequestration of Arpin, a competitive inhibitor of Arp2/3 complex. FSTL1 blocks Wnt7a-mediated repression of extracellular signal–regulated kinase phosphorylation, enabling production of MMP9, which degrades the extracellular matrix and facilitates metastasis. The prognostic significance of the FSTL1-DIAPH1 gene pair makes it an attractive target for therapeutic intervention.

scholarly journals 754 A crosstalk between the alpha and beta adrenergic receptors regulates keratinocyte migration

2016 ◽  
Vol 136 (5) ◽  
pp. S133
Author(s):  
H. Yang ◽  
P. Steenhuis ◽  
A. Glucksman ◽  
Z. Gurenko ◽  
C.M. Nguyen ◽  
...  
Keyword(s):  
Adrenergic Receptors ◽  
Beta Adrenergic Receptors ◽  
Beta Adrenergic ◽  
Keratinocyte Migration
Sign in / Sign up

Export Citation Format

Share Document