A RISC Design: Synthesis of the MIPS Processor Core

In automated control systems for technical processes, the conversion of a continuous signal into a digital code and vice versa from a digital code to a continuous (analog) value is widely used. For direct type converters often used the term ADC, the reverse - DAC. The characteristics of the converters often dramatically affect the parameters of the entire automated system. The importance of the correct choice of ADCs and DACs has especially increased recently in connection with the mass introduction of microcontrollers MC. Indeed, in addition to the ADC and DAC, it is necessary to place the processor core in the microcontroller's crystal, I/O interfaces and many other elements necessary for the functioning of the MC. The use of information converters in the construction industry imposes additional requirements on converters: for example, in building monitoring systems, precision ADCs with extremely high accuracy are often required (while performance may be low), in other applications it is necessary to provide the necessary parameters at a high level of industrial interference, etc. This article explores issues related to the rational choice of ADCs and DACs, taking into account current trends in the IT field and the specifics of work in the construction industry. Sigma-Delta converters are noted as the most promising models of direct type converters.


2002 ◽  
Vol 724 ◽  
Author(s):  
Elizabeth R. Wright ◽  
R. Andrew McMillan ◽  
Alan Cooper ◽  
Robert P. Apkarian ◽  
Vincent P. Conticello

AbstractTriblock copolymers have traditionally been synthesized with conventional organic components. However, triblock copolymers could be synthesized by the incorporation of two incompatible protein-based polymers. The polypeptides would differ in their hydrophobicity and confer unique physiochemical properties to the resultant materials. One protein-based polymer, based on a sequence of native elastin, that has been utilized in the synthesis of biomaterials is poly (Valine-Proline-Glycine-ValineGlycine) or poly(VPGVG) [1]. This polypeptide has been shown to have an inverse temperature transition that can be adjusted by non-conservative amino acid substitutions in the fourth position [2]. By combining polypeptide blocks with different inverse temperature transition values due to hydrophobicity differences, we expect to produce amphiphilic polypeptides capable of self-assembly into hydrogels. Our research examines the design, synthesis and characterization of elastin-mimetic block copolymers as functional biomaterials. The methods that are used for the characterization include variable temperature 1D and 2D High-Resolution-NMR, cryo-High Resolutions Scanning Electron Microscopy and Differential Scanning Calorimetry.


2020 ◽  
Author(s):  
Eleonora Diamanti ◽  
Inda Setyawati ◽  
Spyridon Bousis ◽  
leticia mojas ◽  
lotteke Swier ◽  
...  

Here, we report on the virtual screening, design, synthesis and structure–activity relationships (SARs) of the first class of selective, antibacterial agents against the energy-coupling factor (ECF) transporters. The ECF transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that depend on vitamin uptake. Because of their central role in the metabolism of bacteria and their absence in humans, ECF transporters are novel potential antimicrobial targets to tackle infection. The hit compound’s metabolic and plasma stability, the potency (20, MIC Streptococcus pneumoniae = 2 µg/mL), the absence of cytotoxicity and a lack of resistance development under the conditions tested here suggest that this scaffold may represent a promising starting point for the development of novel antimicrobial agents with an unprecedented mechanism of action.<br>


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