Microbicide Development

2008 ◽  
pp. 115-133
Author(s):  
Ian McGowan
Keyword(s):  
Microbicide Development

Current State of Microbicide Development

2018 ◽  
Vol 104 (6) ◽  
pp. 1074-1081 ◽  
Author(s):  
Yannick L. Traore ◽  
Yufei Chen ◽  
Emmanuel A. Ho
Keyword(s):  
Current State ◽  
Microbicide Development

Report Offers Vision For Microbicide Development

JAMA ◽  
1999 ◽  
Vol 281 (5) ◽  
pp. 405 ◽  
Author(s):  
Joan Stephenson
Keyword(s):  
Microbicide Development

scholarly journals Advances in HIV microbicide development

2011 ◽  
Vol 3 (16) ◽  
pp. 2101-2116 ◽  
Author(s):  
Joanna S Olsen ◽  
David Easterhoff ◽  
Stephen Dewhurst
Keyword(s):  
Microbicide Development ◽  
Hiv Microbicide

Vaginal and Rectal Topical Microbicide Development: Safety and Efficacy of 1.0% Savvy (C31G) in the Pigtailed Macaque

2006 ◽  
Vol 33 (11) ◽  
pp. 691-695 ◽  
Author(s):  
Dorothy L. Patton ◽  
Yvonne T. Cosgrove Sweeney ◽  
Jennifer E. Balkus ◽  
Sharon L. Hillier
Keyword(s):  
Safety And Efficacy ◽  
Microbicide Development ◽  
Topical Microbicide

scholarly journals Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins : Implication for microbicide development

2007 ◽  
Vol 5 (1) ◽  
pp. 28 ◽  
Author(s):  
Hela Saïdi ◽  
Nadine Nasreddine ◽  
Mohammad-Ali Jenabian ◽  
Maxime Lecerf ◽  
Dominique Schols ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Plant Lectins ◽  
Microbicide Development ◽  
Hiv 1

scholarly journals The Cationic Properties of SEVI Underlie Its Ability To Enhance Human Immunodeficiency Virus Infection

2008 ◽  
Vol 83 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Nadia R. Roan ◽  
Jan Münch ◽  
Nathalie Arhel ◽  
Walther Mothes ◽  
Jason Neidleman ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Viral Infection ◽  
Amyloid Fibrils ◽  
Underlying Mechanism ◽  
Target Cells ◽  
Mutant Form ◽  
Immunodeficiency Virus ◽  
Microbicide Development ◽  
Future Direction

ABSTRACT Human semen contains peptides capable of forming amyloid fibrils termed semen-derived enhancer of viral infection (SEVI) that can greatly increase human immunodeficiency virus (HIV) infection. While SEVI appears to enhance virion attachment to target cells, its underlying mechanism of action is unknown. We now demonstrate that the intrinsic positive charges of SEVI (pI = 10.21) facilitate virion attachment to and fusion with target cells. A mutant form of SEVI in which lysines and arginines are replaced with alanines retains the ability to form amyloid fibrils but is defective in binding virions and enhancing infection. In addition, the interaction of wild-type SEVI with virions and the ability of these fibrils to increase infection are abrogated in the presence of various polyanionic compounds. These anionic polymers also decrease the enhancement of HIV infection mediated by semen. These findings suggest that SEVI enhances viral infection by serving as a polycationic bridge that neutralizes the negative charge repulsion that exists between HIV virions and target cells. Combinations of agents that neutrale SEVI action and produce HIV virucidal effects are an attractive future direction for microbicide development.

Sign in / Sign up

Export Citation Format

Share Document