Hereditary Diffuse Gastric Cancer

2010 ◽  
pp. 97-107 ◽  
Author(s):  
Prakash K. Pandalai ◽  
Sam S. Yoon
Keyword(s):  
Gastric Cancer ◽  
Hereditary Diffuse Gastric Cancer ◽  
Diffuse Gastric Cancer

Total Gastrectomy for Hereditary Diffuse Gastric Cancer at a Single Center

2017 ◽  
Vol 266 (6) ◽  
pp. 1006-1012 ◽  
Author(s):  
Vivian E. Strong ◽  
Sepideh Gholami ◽  
Manish A. Shah ◽  
Laura H. Tang ◽  
Yelena Y. Janjigian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Total Gastrectomy ◽  
Hereditary Diffuse Gastric Cancer ◽  
Diffuse Gastric Cancer ◽  
Single Center

Prophylactic total gastrectomy in hereditary diffuse gastric cancer: identification of two novel CDH1 gene mutations—a clinical observational study

2014 ◽  
Vol 13 (2) ◽  
pp. 231-242 ◽  
Author(s):  
Linda Bardram ◽  
Thomas V. O. Hansen ◽  
Anne-Marie Gerdes ◽  
Susanne Timshel ◽  
Lennart Friis-Hansen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Observational Study ◽  
Total Gastrectomy ◽  
Gene Mutations ◽  
Hereditary Diffuse Gastric Cancer ◽  
Diffuse Gastric Cancer ◽  
Cdh1 Gene ◽  
Prophylactic Total Gastrectomy

1066 - Phenotypic Expression of Cdh1 Germline Mutations Unselected for Hereditary Diffuse Gastric Cancer

2018 ◽  
Vol 154 (6) ◽  
pp. S-204
Author(s):  
Nicolette J. Rodriguez ◽  
Patrick Reineke ◽  
Holly LaDuca ◽  
Rosa M. Xicola ◽  
Xavier Llor
Keyword(s):  
Gastric Cancer ◽  
Phenotypic Expression ◽  
Germline Mutations ◽  
Hereditary Diffuse Gastric Cancer ◽  
Diffuse Gastric Cancer

scholarly journals MicroRNAs in hereditary diffuse gastric cancer

2016 ◽  
Vol 5 (2) ◽  
pp. 151-154 ◽  
Author(s):  
Mayra-Cecilia Suárez-Arriaga ◽  
Rosa-María Ribas-Aparicio ◽  
Martha-Eugenia Ruiz-Tachiquín
Keyword(s):  
Gastric Cancer ◽  
Hereditary Diffuse Gastric Cancer ◽  
Diffuse Gastric Cancer

Hereditary Diffuse Gastric Cancer (HDGC). An overview.

2021 ◽  
pp. 101820
Author(s):  
L Taja-Chayeb ◽  
S Vidal-Millán ◽  
C Trejo-Becerril ◽  
E Pérez-Cárdenas ◽  
A Chávez-Blanco ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Hereditary Diffuse Gastric Cancer ◽  
Diffuse Gastric Cancer

CDH1 germline mutations in healthy individuals from families with the hereditary diffuse gastric cancer syndrome

2021 ◽  
pp. jmedgenet-2021-108226
Author(s):  
Giovanni Corso ◽  
Francesca Magnoni ◽  
Giulia Massari ◽  
Cristina Maria Trovato ◽  
Alessandra Margherita De Scalzi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Healthy Subjects ◽  
Relevant Literature ◽  
Germline Mutations ◽  
Hereditary Diffuse Gastric Cancer ◽  
Diffuse Gastric Cancer ◽  
Missense Mutations ◽  
Healthy Individuals ◽  
Cancer Syndrome ◽  
The Difference

The objective of this study was to determining the frequency of different sub-types of pathogenic CDH1 germline mutations in healthy and asymptomatic individuals from families with the hereditary diffuse gastric cancer (HDGC) syndrome. Relevant literature dating from 1998 to 2019 was systematically searched for data on CDH1 germline mutations. The collected variants were classified according to their subtype into the following classes: missense, non-sense, splicing, insertions and deletions. The χ2 test was used to estimate if the difference observed between patients with gastric cancer (GC) and unaffected individuals was statistically significant. CDH1 genetic screening data were retrieved for 224 patients with GC and 289 healthy individuals. Among the subjects that had tested CDH1 positive, splicing mutations were found in 30.4% of the healthy individuals and in 15.2% of the patients with GC (p=0.0076). Missense mutations were also found to occur in healthy subjects with higher frequency (22.2%) than in GC-affected individuals (18.3%), but the difference was not significant in this case. In families meeting the clinical criteria for the HDGC syndrome, CDH1 splicing and missense germline mutations have been reported to occur with higher frequency in healthy subjects than in patients with cancer. This preliminary observation suggests that not all pathogenic CDH1 germline mutations confer the same risk of developing GC.

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