Liver Fluke Vaccine Assessment in Cattle

2020 ◽  
pp. 205-212
Author(s):  
Gabriela Maggioli ◽  
Cecilia Salazar ◽  
Federico Fossa ◽  
Carlos Carmona
Keyword(s):  
Liver Fluke

Low Frequency of Mismatch Repair Deficiency in a Large Cohort of Non-liver fluke associated Cholangiocarcinomas

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
B Goeppert ◽  
S Roessler ◽  
M Renner ◽  
S Singer ◽  
A Mehrabi ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Liver Fluke ◽  
Low Frequency ◽  
Large Cohort ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency

A study on the fine structure of Clonorchis sinensis, a liver fluke III.The prostate gland

1980 ◽  
Vol 18 (1) ◽  
pp. 93 ◽  
Author(s):  
Kye Heon Jeong ◽  
Han Jong Rim ◽  
Chang Whan Kim
Keyword(s):  
Fine Structure ◽  
Liver Fluke ◽  
Clonorchis Sinensis ◽  
Prostate Gland

A morphological study on spermatogenesis in the liver fluke, Clonorchis sinensis

1976 ◽  
Vol 14 (2) ◽  
pp. 123 ◽  
Author(s):  
Kye Heon Jeong ◽  
Han Jong Rim ◽  
He Young Yang ◽  
Woo Kap Kim ◽  
Chang Whan Kim
Keyword(s):  
Morphological Study ◽  
Liver Fluke ◽  
Clonorchis Sinensis

Promoter hypermethylation is a major event of hMLH1 gene inactivation in liver fluke related cholangiocarcinoma

2005 ◽  
Vol 217 (2) ◽  
pp. 213-219 ◽  
Author(s):  
Temduang Limpaiboon ◽  
Prasong Khaenam ◽  
Patcharee Chinnasri ◽  
Montisha Soonklang ◽  
Patcharee Jearanaikoon ◽  
...  
Keyword(s):  
Liver Fluke ◽  
Promoter Hypermethylation ◽  
Gene Inactivation ◽  
Major Event ◽  
Hmlh1 Gene

scholarly journals The soluble glutathione transferase superfamily: role of Mu class in triclabendazole sulphoxide challenge in Fasciola hepatica

2021 ◽  
Vol 120 (3) ◽  
pp. 979-991
Author(s):  
Rebekah B. Stuart ◽  
Suzanne Zwaanswijk ◽  
Neil D. MacKintosh ◽  
Boontarikaan Witikornkul ◽  
Peter M. Brophy ◽  
...  
Keyword(s):  
In Vitro Culture ◽  
Liver Fluke ◽  
Glutathione Transferase ◽  
Fasciola Hepatica ◽  
Affinity Purification ◽  
Economic Loss ◽  
Differential Abundance ◽  
Parasitic Helminths

AbstractFasciola hepatica (liver fluke), a significant threat to food security, causes global economic loss for the livestock industry and is re-emerging as a foodborne disease of humans. In the absence of vaccines, treatment control is by anthelmintics; with only triclabendazole (TCBZ) currently effective against all stages of F. hepatica in livestock and humans. There is widespread resistance to TCBZ and its detoxification by flukes might contribute to the mechanism. However, there is limited phase I capacity in adult parasitic helminths with the phase II detoxification system dominated by the soluble glutathione transferase (GST) superfamily. Previous proteomic studies have demonstrated that the levels of Mu class GST from pooled F. hepatica parasites respond under TCBZ-sulphoxide (TCBZ-SO) challenge during in vitro culture ex-host. We have extended this finding by exploiting a sub-proteomic lead strategy to measure the change in the total soluble GST profile (GST-ome) of individual TCBZ-susceptible F. hepatica on TCBZ-SO-exposure in vitro culture. TCBZ-SO exposure demonstrated differential abundance of FhGST-Mu29 and FhGST-Mu26 following affinity purification using both GSH and S-hexyl GSH affinity. Furthermore, a low or weak affinity matrix interacting Mu class GST (FhGST-Mu5) has been identified and recombinantly expressed and represents a new low-affinity Mu class GST. Low-affinity GST isoforms within the GST-ome was not restricted to FhGST-Mu5 with a second likely low-affinity sigma class GST (FhGST-S2) uncovered. This study represents the most complete Fasciola GST-ome generated to date and has supported the potential of subproteomic analyses on individual adult flukes.

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