Pharmacokinetics of pethidine and norpethidine in the rat: an application of selected ion monitoring using deuterated internal standards

1978 ◽  
pp. 107-112
Author(s):  
C. Lindberg ◽  
C. Bogentoft ◽  
B. Dahlström ◽  
L. Paalzow
Keyword(s):  
Selected Ion Monitoring ◽  
Internal Standards

Characterization of drug interferences caused by coelution of substances in gas chromatography/mass spectrometry confirmation of targeted drugs in full-scan and selected-ion monitoring modes

1994 ◽  
Vol 40 (2) ◽  
pp. 216-220 ◽  
Author(s):  
A H Wu ◽  
D Ostheimer ◽  
M Cremese ◽  
E Forte ◽  
D Hill
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography Mass Spectrometry ◽  
Spectrometric Analysis ◽  
Targeted Drugs ◽  
Selected Ion Monitoring ◽  
Internal Standards ◽  
Target Drug ◽  
Full Scan ◽  
Chromatographic Mass

Abstract Interference by substances coeluting with targeted drugs is a general problem for gas chromatographic/mass spectrometric analysis of urine. To characterize these interferences, we examined human urine samples containing benzoylecgonine and fluconazole, and other drug combinations including deuterated internal standards that coelute (ISd,c) with target drugs, by selected-ion monitoring (SIM) and full-scan mass spectrometry. We show that, by SIM analysis, detecting the presence of an interferent is dependent on the specific IS used for the assay. When an ISd,c is used, the presence of another coeluting substance (interferent) suggests that the intensity of IS ions is substantially diminished, because the interferent affects both the ISd,c and target drug. When a noncoeluting IS (ISnc) is used, the interferent cannot be discerned unless it coincidently contains one or more of the ions monitored for either the target drug or ISnc. Under full-scan analysis, a coeluting interferent is directly discernable by examining the total ion gas chromatogram.

scholarly journals Simultaneous determination of five androgens in early neonatal urine by selected ion monitoring GC-MS using 19-d3 steroids as internal standards.

1985 ◽  
Vol 32 (2) ◽  
pp. 279-285 ◽  
Author(s):  
TAKASHI YAMAGUCHI ◽  
KUNIO KONNO ◽  
KATSUHIRO KAWABE ◽  
KIKUO YASUDA ◽  
HIROMU MORI ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Selected Ion Monitoring ◽  
Internal Standards

Selected ion monitoring of metoprolol and two metabolites in plasma and urine using deuterated internal standards

1981 ◽  
Vol 8 (7) ◽  
pp. 322-326 ◽  
Author(s):  
Magnar Ervik ◽  
Kurt-Jürgen Hoffmann ◽  
Kerstin Kylberg-Hanssen
Keyword(s):  
Selected Ion Monitoring ◽  
Internal Standards

scholarly journals Gibberellin Status of Spectral Filter-grown Chrysanthemum Plants

HortScience ◽  
1996 ◽  
Vol 31 (4) ◽  
pp. 581c-581
Author(s):  
Sorua L. Maki ◽  
Melissa B. Riley ◽  
Nihal C. Rajapakse
Keyword(s):  
High Performance ◽  
Reversed Phase ◽  
Retention Indices ◽  
Gas Chromatography Mass Spectrometry ◽  
Spectral Filter ◽  
Selected Ion Monitoring ◽  
Shoot Apices ◽  
Internal Standards ◽  
Methanolic Extracts ◽  
Kováts Retention Indices

Endogenous gibberellins of chrysanthemum [Dendranthema ×grandiflorum (Ramat)] cv. Bright Golden Anne were characterized in apices from plants grown under control and CuSO4 spectral filters. Expanding shoots were separated into young expanding leaves and apices. Methanolic extracts of young expanding leaves were purified by solvent partitioning, PVPP column chromatography and reversed-phase high performance liquid chromatography. Two bioactive regions corresponding to the HPLC retention times of GA1 and GA19 standards were detected in fractions using the recently-developed non-dwarf rice bioassay. Di-deuterated internal standards of GA12, GA53, GA19, GA20, and GA1 were added to similar extracts of shoot apices. The presence of endogenous GA53, GA19, GA20, and GA1 in chrysanthemum apices was confirmed by isotope dilution using gas chromatography-mass spectrometry-selected ion monitoring and Kovats retention indices. In a preliminary quantification study, GA20 and GA1 levels were found to be higher in apices from plants grown under control filters while GA19 levels were higher in apices grown under CuSO4 filters. The possibility that light transmitted through CuSO4 filters alters gibberellin levels in shoot apices is discussed.

scholarly journals GIBBERELLIN PHYSIOLOGY OF SPECTRAL FILTER-GROWN CHRYSANTHEMUM PLANTS

HortScience ◽  
1996 ◽  
Vol 31 (5) ◽  
pp. 752b-752
Author(s):  
Sonja L. Maki ◽  
Nihal C. Rajapakse
Keyword(s):  
High Performance ◽  
Internal Standard ◽  
Reversed Phase ◽  
Retention Indices ◽  
Gas Chromatography Mass Spectrometry ◽  
Selected Ion Monitoring ◽  
Internal Standards ◽  
Methanolic Extracts ◽  
Kováts Retention Indices ◽  
Deuterated Internal Standard

Endogenous gibberellins of chrysanthemum [Dendrathema×grandiflorum (Ramat) cv. Bright Golden Anne] were characterized in preparation for quantification of endogenous gibberellins in apices under control and CuSO4 spectral filters. Expanding shoots were separated into young expanding leaves and apices. Methanolic extracts of young expanding leaves were purified by solvent partitioning, PVPP column chromatography, and reversed-phase high performance liquid chromatography. Two bioactive regions corresponding to the HPLC retention times of GA and GA19 standards were detected in fractions using the recently developed non-dwarf rice bioassay. Dideuterated internal standards of GA12, GA53, GA19, GA20, and GA1 were added to similar extracts of shoot apices. The presence of endogenous GA53, GA19, GA20, and GA1 in chrysanthemum apices was confirmed by isotope dilution using gas chromatography–mass spectrometry-selected ion monitoring and Kovats retention indices. Ions for the deuterated internal standard of GA12 were detected, but not for endogenous GA12. The above results demonstrate that the early 13-hydroxylation pathway operates in chrysanthemum.

Simultaneous Analysis of Grain and Grain-Based Products for Ethylene Dibromide, Carbon Tetrachloride, and Ethylene Dichloride

1986 ◽  
Vol 69 (4) ◽  
pp. 575-580
Author(s):  
Thomas G Alleman ◽  
Robert A Sanders ◽  
Bryan L Madison
Keyword(s):  
Gas Chromatography ◽  
Carbon Tetrachloride ◽  
Mass Spectrometer ◽  
Simultaneous Measurement ◽  
Capillary Gas Chromatography ◽  
Ethylene Dichloride ◽  
Selected Ion Monitoring ◽  
Internal Standards ◽  
Ethylene Dibromide ◽  
Precision And Accuracy

Abstract A method is described for the simultaneous measurement of parts per billion levels of the fumigants ethylene dibromide, carbon tetrachloride, and ethylene dichloride in grain and grain-based products. The fumigants are isolated by hexane co-distillation, separated by capillary gas chromatography, and detected with a mass spectrometer in the selected ion monitoring mode. Recoveries are greater than 90% and standard deviations are approximately 10% of the quantity measured. The method is free of interferences and its precision and accuracy are enhanced by the use of tetradeuterated ethylene dibromide and ethylene dichloride as internal standards.

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