Effects of naloxone in normal, manic, and schizophrenic patients: evidence for alleviation of manic symptoms

Manic Symptoms during a Switch from Paliperidone ER to Paliperidone Palmitate in a Patient with Schizophrenia

Case Reports in Psychiatry ◽

10.1155/2015/528370 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Kadir Demirci ◽

Süleyman Keleş ◽

Arif Demirdaş ◽

Cafer Çağrı Korucu

Keyword(s):

Bipolar Disorder ◽

Female Patient ◽

Treatment Efficacy ◽

Antipsychotic Drugs ◽

Manic Episode ◽

Paliperidone Palmitate ◽

Manic Symptoms ◽

Schizophrenic Patients

Some antipsychotic drugs have treatment efficacy for mania and bipolar disorder. However, these drugs may rarely cause manic symptoms in some schizophrenic patients. We hereby report a 22-year-old female patient with schizophrenia who experienced a manic episode during a switch from paliperidone ER to paliperidone palmitate. This case is an important reminder that an abrupt switch from oral paliperidone to paliperidone palmitate may predispose certain patients to hypomanic or manic symptoms.

Download Full-text

Brain electric microstates in schizophrenic patients display deviant adaptation of the functional brain state

Electroencephalography and Clinical Neurophysiology ◽

10.1016/s0013-4694(97)88377-4 ◽

1997 ◽

Vol 103 (1) ◽

pp. 92

Author(s):

T Koenig

Keyword(s):

Brain State ◽

Functional Brain ◽

Schizophrenic Patients

Download Full-text

The self and schizophrenia: a cognitive approach

Swiss Journal of Psychology ◽

10.1024//1421-0185.62.1.45 ◽

2003 ◽

Vol 62 (1) ◽

pp. 45-51 ◽

Cited By ~ 5

Author(s):

Marek Nieznanski

Keyword(s):

Normal Subjects ◽

Control Group ◽

Cognitive Approach ◽

Schizophrenic Patients ◽

Self Schema ◽

Persons With Schizophrenia ◽

Basic Features ◽

Trait Words ◽

Patients Experience ◽

Normal Controls

The aim of the study was to explore the basic features of self-schema in persons with schizophrenia. Thirty two schizophrenic patients and 32 normal controls were asked to select personality trait words from a check-list that described themselves, themselves as they were five years ago, and what most people are like. Compared with the control group, participants from the experimental group chose significantly more adjectives that were common to descriptions of self and others, and significantly less that were common to self and past-self descriptions. These results suggest that schizophrenic patients experience their personality as changing over time much more than do healthy subjects. Moreover, their self-representation seems to be less differentiated from others-representation and less clearly defined than in normal subjects.

Download Full-text

Suicidal Behavior in German Adolescents

Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie ◽

10.1024/1422-4917/a000331 ◽

2015 ◽

Vol 43 (1) ◽

pp. 39-45 ◽

Cited By ~ 4

Author(s):

Joana Straub ◽

Ferdinand Keller ◽

Nina Sproeber ◽

Michael G. Koelch ◽

Paul L. Plener

Keyword(s):

Suicidal Behavior ◽

Suicide Attempts ◽

Depression Scale ◽

Epidemiological Studies ◽

Present Sample ◽

Manic Symptoms ◽

Symptoms Of Depression ◽

Adolescent Sample ◽

History Of ◽

Sum Scores

Objective: Research in adults has identified an association between bipolar disorder and suicidal behavior. This relationship, however, has been insufficiently investigated in adolescents to date. Methods: 1,117 adolescents from 13 German schools (mean age = 14.83, SD = .63; 52.7% females) completed an extended German version of the Center for Epidemiological Studies Depression Scale (CES-D), which assesses depressive and manic symptoms during the last week, as well as the Self-Harm Behavior Questionnaire (SHBQ) for the assessment of lifetime suicidal behavior. Results: In the present sample 39.4% of the girls and 23.1% of the boys reported lifetime suicidal thoughts and 7.1% of the girls as well as 3.9% of the boys a lifetime history of suicide attempts. 18.7% of the adolescent sample revealed elevated symptoms of depression and 9% elevated levels of mania symptoms. Elevated sum scores of depression and mania were associated with a higher number of suicidal ideations and suicide attempts. A block-wise regression analysis revealed that sum scores of depression and mania predicted suicidal ideations best. Concerning suicide attempts, the best predictors were age as well as depression and mania sum scores. Conclusions: Suicidal behavior was reported more often when adolescents demonstrate symptoms of mania as well as symptoms of depression than when they demonstrate only depressive symptoms. The presence of bipolar symptoms in adolescents should alert clinicians to the heightened possibility of suicidal behavior.

Download Full-text

An ERP Investigation of Semantic Priming, Repetition Priming, and Negative Priming in Schizophrenic Patients

Journal of Psychophysiology ◽

10.1027/0269-8803.20.3.195 ◽

2006 ◽

Vol 20 (3) ◽

pp. 195-211 ◽

Cited By ~ 7

Author(s):

Michael Wagner ◽

Lioba Baving ◽

Patrick Berg ◽

Rudolf Cohen ◽

Brigitte Rockstroh

Keyword(s):

Negative Priming ◽

Repetition Priming ◽

Event Related Potentials ◽

Decision Task ◽

Positive Priming ◽

Retrieval Processes ◽

Schizophrenic Patients ◽

Related Potentials ◽

Late Positive Complex ◽

Automatic Memory

The processing of attended and nonattended stimuli in schizophrenic patients was examined with event-related potentials (ERPs) in a lexical decision task. In positive semantic and repetition priming the N400 amplitude did not differ between a group of 17 medicated schizophrenic patients and a group of 20 matched healthy controls. However, negative priming affected the N400 only in controls. Reaction time effects were dissociated from these ERP effects, with patients showing stronger positive priming than controls but identical negative priming. The semantic processes related to the N400 appear to be intact in schizophrenic patients, but patients seem to incorporate less context information (about the nonattended prime) in their episodic memory traces. A stronger increase of the posterior late positive complex in parallel to the stronger positive priming in schizophrenic patients may reflect relatively stronger automatic memory retrieval processes in patients.

Download Full-text

The Antiaggressive Action of Combined Haloperidol-Propranolol Treatment in Schizophrenia

European Psychologist ◽

10.1027//1016-9040.5.4.312 ◽

2000 ◽

Vol 5 (4) ◽

pp. 312-325 ◽

Cited By ~ 9

Author(s):

Gadi Maoz ◽

Daniel Stein ◽

Sorin Meged ◽

Larisa Kurzman ◽

Joseph Levine ◽

...

Keyword(s):

Rating Scales ◽

Double Blind ◽

Propranolol Group ◽

Schizophrenic Patients ◽

Propranolol Treatment ◽

Simultaneous Decrease ◽

The Mean ◽

Haloperidol Treatment ◽

To Receive ◽

Drug Free

Psychopharmacological interventions for managing aggression in schizophrenia have thus far yielded inconsistent results. This study evaluates the antiaggressive efficacy of combined haloperidol-propranolol treatment. Thirty-four newly admitted schizophrenic patients were studied in a controlled double-blind trial. Following a 3-day drug-free period and 7 days of haloperidol treatment, patients were randomly assigned to receive either haloperidol-propranolol or haloperidol-placebo for eight consecutive weeks. Doses of medications were adjusted as necessary; biperiden was administered if required. Rating scales were applied to assess aggression, anger, psychosis, depression, anxiety and extrapyramidal symptoms. The mean daily dose of haloperidol was 21 mg (SD = 6.4) in the research group and 29 mg (SD = 6.9) in the controls. Mean and maximal daily doses of propranolol were 159 mg (SD = 61) and 192 mg (SD = 83), and of placebo, 145 mg (SD = 50) and 180 mg (SD = 70), respectively. Compared with the controls, the scores for the research patients decreased significantly from baseline, particularly after 4 weeks of treatment, for some dimensions of anger, psychosis, anxiety, and neuroleptic-induced parkinsonism. A tendency for reduced aggression was shown in the combined haloperidol-propranolol group for some dimensions but not others. These patients also required significantly less biperiden. The tendency toward elevated antiaggressive effect of combined haloperidol-propranolol treatment compared to haloperidol alone may be explained by a simultaneous decrease in aggression, psychotic symptomatology, and anxiety.

Download Full-text