The pharmacological inhibition of phospholipid methylation

1982 ◽  
pp. 149-153 ◽  
Author(s):  
Peter K Chiang ◽  
Sanford J Shattil
Keyword(s):  
Pharmacological Inhibition

Pharmacological inhibition of nicotinamide N-methyltransferase (NNMT) in adipocytes by romidepsin

2016 ◽  
Vol 11 (S 01) ◽  
Author(s):  
B Zapp ◽  
B Rudolphi ◽  
NA Kraus ◽  
J Klein ◽  
C Wanner ◽  
...  
Keyword(s):  
Pharmacological Inhibition

Demonstration and Quantitation of Pharmacological Inhibition of Pulmonary Uptake of N-lsopropyl-123l-p-lodoamphetamine by Propranolol

1989 ◽  
Vol 28 (03) ◽  
pp. 100-104 ◽  
Author(s):  
S. F. Akber
Keyword(s):  
Binding Sites ◽  
Bolus Injection ◽  
Cell Function ◽  
Lung Pathology ◽  
Lung Uptake ◽  
Pharmacological Inhibition ◽  
Sensitive Index ◽  
Pulmonary Uptake ◽  
First Pass

The first-pass pulmonary extraction values of N-lsopropyl-123l-p-lodoamphetamine (123I-IMP) in pretreated dogs decreases from 90 to 62% as the amount of propranolol increases from 0 to 20 mg. The first-pass pulmonary extraction values of 123I-IMP in dogs with a simultaneous bolus injection of propranolol decreases from 90 to 62% as the amount of propranolol increases from 0 to 10 mg. The pulmonary extraction of 123I-IMP with a simultaneous bolus injection of ketamine and 123I-IMP decreases from 90 to 64% as the ketamine dose increases from 0 to 100 mg. These results suggest that the pulmonary uptake of 123I-IMP may be at least partially mediated by receptors. They also indicate that endothelial metabolic cell function may be a useful index of early lung pathology. Furthermore, studies of the degree of lung uptake may be a sensitive index of pathologic states in which alterations of amine binding sites have occurred.

Genetic or pharmacological inhibition of cyclin-dependent kinase 2 in Hepatic Stellate Cells acts anti-fibrotic

2020 ◽  
Author(s):  
A Hübbers ◽  
J Hennings ◽  
D Lambertz ◽  
C Trautwein ◽  
C Liedtke ◽  
...  
Keyword(s):  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Cyclin Dependent Kinase ◽  
Pharmacological Inhibition

Effects of long-term pharmacological inhibition of CGRP signaling on bone and glucose metabolism

2020 ◽  
Author(s):  
P Köhli ◽  
J Appelt ◽  
D Jahn ◽  
E Otto ◽  
A Baranowsky ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Pharmacological Inhibition
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