Breast Conservation Treatment of Early Stage Breast Carcinoma: Risk of Cardiac Mortality

2008 ◽  
pp. 673-695
Author(s):  
Eleanor E. R. Harris
Keyword(s):  
Breast Carcinoma ◽  
Early Stage ◽  
Breast Conservation ◽  
Cardiac Mortality ◽  
Conservation Treatment ◽  
Breast Conservation Treatment ◽  
Carcinoma Risk

Time Course of Mild Arm Lymphedema After Breast Conservation Treatment for Early-Stage Breast Cancer

2010 ◽  
Vol 76 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Voichita Bar Ad ◽  
Andrea Cheville ◽  
Lawrence J. Solin ◽  
Pinaki Dutta ◽  
Stefan Both ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Time Course ◽  
Early Stage ◽  
Breast Conservation ◽  
Early Stage Breast Cancer ◽  
Conservation Treatment ◽  
Breast Conservation Treatment ◽  
Arm Lymphedema

Late Cardiac Mortality and Morbidity in Early-Stage Breast Cancer Patients After Breast-Conservation Treatment

2006 ◽  
Vol 24 (25) ◽  
pp. 4100-4106 ◽  
Author(s):  
Eleanor E.R. Harris ◽  
Candace Correa ◽  
Wei-Ting Hwang ◽  
Jessica Liao ◽  
Harold I. Litt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Breast Conservation ◽  
Cardiac Mortality ◽  
Mortality And Morbidity ◽  
Conservation Treatment ◽  
Breast Conservation Treatment ◽  
Artery Disease

Purpose Several studies have reported increased cardiac mortality related to the use of left-sided breast or chest-wall irradiation. This study was undertaken as a comprehensive examination of the long-term cardiac mortality and morbidity after breast irradiation using contemporary irradiation techniques. Methods The medical records of 961 consecutive patients presenting between 1977 and 1994 with stage I or II breast cancer treated with breast conservation treatment were reviewed. Data was recorded on baseline pretreatment patient, tumor and treatment characteristics and on subsequent cancer or cardiac related events. The median follow-up time was 12 years. Results There was no difference in overall mortality from any cardiac cause (P = .25). Death from any cardiac cause occurred in 2% of right-sided patients and 3.5% of left-sided patients. However, in the second decade after treatment, there was a higher rate of cardiac deaths in left-sided patients, with a cumulative risk of 6.4% (95% CI, 3.5% to 11.5%) for left-sided compared with 3.6% (95% CI, 1.8% to 7.2%) for right-sided patients at 20 years. There were statistically higher rates of chest pain, coronary artery disease, and myocardial infarction diagnosed in left-sided patients (all P ≤ .002). The presence of hypertension was associated with a higher risk of coronary artery disease in left-sided patients. Conclusion Irradiation to the left breast is not associated with a higher risk of cardiac death up to 20 years after treatment, but is associated with an increased rate of diagnoses of coronary artery disease and myocardial infarction compared with right breast treatment.

Sign in / Sign up

Export Citation Format

Share Document