Pathogenesis of Multiple Sclerosis: Relationship to Therapeutic Strategies

1992 ◽  
pp. 123-133 ◽  
Author(s):  
Richard M. Ransohoff
Keyword(s):  
Multiple Sclerosis ◽  
Therapeutic Strategies

Urethral Diverticulum in Women with Neurologic Bladder

1998 ◽  
Vol 65 (4) ◽  
pp. 532-535
Author(s):  
P. Menchinelli ◽  
L De Giovanni ◽  
A. Manca ◽  
J.M. Weir ◽  
G. Ronzoni
Keyword(s):  
Multiple Sclerosis ◽  
Urethral Diverticulum ◽  
Therapeutic Strategies ◽  
Long Term Results ◽  
White Population ◽  
Diagnostic Work ◽  
Work Up ◽  
Female Urethral Diverticulum ◽  
Diagnostic Work Up

Female urethral diverticulum is a rather rare pathology, often ignored, which affects from 1 to 4% of the white population. In this study we report our series, limited to a selected population of women affected by neurologic bladder (6 paraplegic patients; 2 patients with multiple sclerosis) who were referred to our Urosurgical Unit within the space of four years. The diagnostic work-up relevant to these patients is discussed, together with the therapeutic strategies carried out and the long-term results obtained.

scholarly journals The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Helen Könnecke ◽  
Ingo Bechmann
Keyword(s):  
Multiple Sclerosis ◽  
Matrix Metalloproteinases ◽  
Current Knowledge ◽  
Malignant Gliomas ◽  
Therapeutic Strategies ◽  
Glioma Invasion ◽  
Glia Limitans ◽  
And Migration

Matrix metalloproteinases (MMPs) are involved in the pathogenesis of neuroinflammatory diseases (such as multiple sclerosis) as well as in the expansion of malignant gliomas because they facilitate penetration of anatomical barriers (such as the glia limitans) and migration within the neuropil. This review elucidates pathomechanisms and summarizes the current knowledge of the involvement of MMPs in neuroinflammation and glioma, invasion highlighting microglia as major sources of MMPs. The induction of expression, suppression, and multiple pathways of function of MMPs in these scenarios will also be discussed. Understanding the induction and action of MMPs might provide valuable information and reveal attractive targets for future therapeutic strategies.

Novel therapeutic strategies targeting the pathogenic T-cells in multiple sclerosis

2005 ◽  
Vol 1 (3) ◽  
pp. 345-355 ◽  
Author(s):  
Mark T Muir ◽  
Amy E Lovett-Racke ◽  
Michael K Racke
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Stem Cell and Gene Therapeutic Strategies for the Treatment of Multiple Sclerosis

2009 ◽  
Vol 9 (8) ◽  
pp. 992-1016 ◽  
Author(s):  
Christopher Siatskas ◽  
Claude Bernard
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cell ◽  
Therapeutic Strategies

scholarly journals Novel therapeutic strategies for multiple sclerosis: potential of intravenous immunoglobulin

2009 ◽  
Vol 8 (7) ◽  
pp. 594-594 ◽  
Author(s):  
Jagadeesh Bayry ◽  
Sébastien Lacroix-Desmazes ◽  
Srini V. Kaveri
Keyword(s):  
Multiple Sclerosis ◽  
Intravenous Immunoglobulin ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

scholarly journals Targeting VIP and PACAP Receptor Signalling: New Therapeutic Strategies in Multiple Sclerosis

ASN NEURO ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. AN20110024 ◽  
Author(s):  
Yossan-Var Tan ◽  
James A Waschek
Keyword(s):  
Multiple Sclerosis ◽  
Therapeutic Strategies ◽  
Receptor Signalling
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