Pulse Pressure Amplification and Arterial Stiffness in Middle Age

2014 ◽  
pp. 281-295
Author(s):  
Alberto P. Avolio ◽  
Mark Butlin ◽  
Athanase D. Protogerou
Keyword(s):  
Arterial Stiffness ◽  
Pulse Pressure ◽  
Middle Age ◽  
Pressure Amplification

Abstract MP100: Arterial Stiffness and Pressure Amplification Associated with Markers of Cerebral Microvascular Disease: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Priya Palta ◽  
Jingkai Wei ◽  
Michelle Meyer ◽  
Melinda C Power ◽  
Jennifer A Deal ◽  
...  
Keyword(s):  
Older Adults ◽  
Arterial Stiffness ◽  
Pulse Pressure ◽  
Aortic Stiffness ◽  
Brain Mri ◽  
Intracranial Volume ◽  
Sampling Weights ◽  
Arterial Stiffening ◽  
Lacunar Infarcts ◽  
Pressure Amplification

Introduction: Small vessel disease is associated with decreased cognitive function, possibly differential by race. Age-related central arterial stiffening increases pulsatility resulting in hypoperfusion, microvascular damage and remodeling in the brain, potentially impairing cognition. We examined if arterial stiffness and pressure amplification are associated with lacunar infarcts and greater volumes of white matter hyperintensities (WMH) in a sample of Caucasian and African American (AA) older adults. Methods: We analyzed a cross-sectional sample of ARIC participants aged 67-90 years (n=1486) from visit 5 (2011-2013), with brain magnetic resonance imaging (MRI). The Omron VP-1000 Plus was used to measure aortic stiffness (carotid-femoral pulse wave velocity [cfPWV]) and pressure amplification measures (pulse pressure amplification [PPA], central pulse pressure [cPP], and estimated central systolic blood pressure [cSBP]). Aortic stiffness and pressure amplification were dichotomized at race-specific 25th percentile cut points. Brain MRI using 3D-1.5T equipment quantified the presence of lacunar infarcts and volumes of WMH following a standardized protocol. Logistic regression, adjusted for age, sex, education, ApoE4, heart rate, smoking and body mass index, was used to quantify the odds of lacunar infarcts in participants with high vs. low cfPWV, cPP, cSBP, and low vs. high PPA. Linear regression models, additionally adjusted for intracranial volume, estimated the difference in log-transformed volumes of WMH among participants with high vs. low cfPWV, cPP, cSBP, and low vs. high PPA. Probability sampling weights for an MRI were included to allow for generalizability to the full visit 5 cohort. Results: Among the 1486 participants with a brain MRI (mean age: 76, 41% male, 26% AA), measures of aortic stiffness and pressure amplification were associated with lacunar infarcts in Caucasians, but not in AAs. Caucasian participants with a high cfPWV had greater odds of lacunar infarcts (Odds Ratio [OR] =2.02, 95% confidence interval [CI]: 1.23, 2.20). Caucasians with high cSBP had higher odds of lacunar infarcts (OR=1.72, 95% CI: 1.10, 2.69). In Caucasians, high cfPWV was associated with a 21% (95% CI: 6, 38) greater volume of WMH as compared to a low cfPWV; high cSBP was associated with a 28% (95% CI: 14, 45) greater volume of WMH compared to a low cSBP. In AAs, high cfPWV was associated with a 32% (95% CI: 7, 62) greater volume of WMH as compared to low cfPWV. Cerebral microvascular imaging markers did not differ quantitatively with measures of PPA and cPP. Conclusions: Central arterial stiffening and pressure amplification are plausible microvascular contributors to cognitive aging, providing new information on modifiable pathways for previously observed associations between cardiovascular disease risk factors and the rates of cognitive decline and dementia among older adults.

Pulse Pressure Amplification and Arterial Stiffness in Low-Risk, Uncomplicated Pregnancies

Angiology ◽  
2015 ◽  
Vol 67 (4) ◽  
pp. 375-383 ◽  
Author(s):  
YH Gomez ◽  
Zahra Hudda ◽  
Noha Mahdi ◽  
Anais Hausvater ◽  
Lucie Opatrny ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pulse Pressure ◽  
Low Risk ◽  
Pressure Amplification

NITRIC OXIDE DOES NOT CONTRIBUTE TO ALTERED PULSE PRESSURE AMPLIFICATION OR ARTERIAL STIFFNESS DURING AEROBIC EXERCISE IN HEALTHY MEN

2004 ◽  
Vol 22 (Suppl. 2) ◽  
pp. S299
Author(s):  
J. E. Sharman ◽  
C. M. McEniery ◽  
R. Campbell ◽  
P. Pusalkar ◽  
I. B. Wilkinson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Pulse Pressure ◽  
Healthy Men ◽  
Pressure Amplification

scholarly journals Effect of Smoking on Arterial Stiffness and Pulse Pressure Amplification

Hypertension ◽  
2003 ◽  
Vol 41 (1) ◽  
pp. 183-187 ◽  
Author(s):  
Azra Mahmud ◽  
John Feely
Keyword(s):  
Arterial Stiffness ◽  
Pulse Pressure ◽  
Pressure Amplification

scholarly journals Assessment of variations in arterial tone during different phases of menstrual cycle

2019 ◽  
Vol 8 (5) ◽  
pp. 1810
Author(s):  
E. Umapathy ◽  
S. T. Muthiraparampil ◽  
A. Namugowa
Keyword(s):  
Menstrual Cycle ◽  
Arterial Stiffness ◽  
Pulse Pressure ◽  
Luteal Phase ◽  
Augmentation Index ◽  
Pressure Gauge ◽  
African Women ◽  
Pressure Amplification ◽  
Student Volunteers ◽  
Arterial Tone

Background: Arterial tone parameters in young African women during the different phases of menstrual cycle were assessed in the present study.Methods: Out of the 30 student volunteers who participated in the study, only 15 completed the study. Anthropometric data using stadiometer, blood pressure using automated oscillometric pressure gauge were measured. Arterial stiffness parameters at the radial and ECG gated carotid and femoral arteries using sphygmocor tonometry was mesured in two consecutive menstrual cycles at early follicular, ovulation and luteal phase. Estrogen and progesterone concentrations were analyzed using Elisa kits in all three phases.Results: Estrogen level in ovulation phase and progesterone in luteal phase were higher. Peripheral augmentation index in ovulation phase was higher compared to luteal phase. Pulse pressure amplification value at follicular and luteal phases was higher than in ovulation phase. Pulse wave velocity and pulse pressure amplification was negatively correlated to progesterone in follicular phase. The arterial stiffness increased at ovulation and decreased in follicular and luteal phases of menstrual cycle.Conclusions: No significant correlation between arterial stiffness parameters and ovarian hormones was found.

scholarly journals Arterial Stiffness and Pulse-Pressure Amplification in Overweight/Obese African- American Adolescents: Relation With Higher Systolic and Pulse Pressure

2012 ◽  
Vol 26 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Gary L. Pierce ◽  
Haidong Zhu ◽  
Katherine Darracott ◽  
Itoro Edet ◽  
Jigar Bhagatwala ◽  
...  
Keyword(s):  
African American ◽  
Arterial Stiffness ◽  
Pulse Pressure ◽  
African American Adolescents ◽  
Pressure Amplification
Sign in / Sign up

Export Citation Format

Share Document