Gene Organization and Recombination Hot Spots in the Murine Major Histocompatibility Complex

1986 ◽  
pp. 31-42
Author(s):  
Michael Steinmetz
Keyword(s):  
Major Histocompatibility Complex ◽  
Hot Spots ◽  
Gene Organization ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Recombination Hot Spots

Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates

Genetics ◽  
2004 ◽  
Vol 166 (4) ◽  
pp. 1897-1907
Author(s):  
Hiromi Sawai ◽  
Yoshi Kawamoto ◽  
Naoyuki Takahata ◽  
Yoko Satta
Keyword(s):  
Major Histocompatibility Complex ◽  
Distinct Group ◽  
Gene Organization ◽  
Class I ◽  
Phylogenetic Position ◽  
Specific Gene ◽  
New World Monkeys ◽  
Major Histocompatibility ◽  
Nucleotide Substitutions ◽  
Histocompatibility Complex

Abstract New World monkeys (NWMs) occupy a critical phylogenetic position in elucidating the evolutionary process of major histocompatibility complex (MHC) class I genes in primates. From three subfamilies of Aotinae, Cebinae, and Atelinae, the 5′-flanking regions of 18 class I genes are obtained and phylogenetically examined in terms of Alu/LINE insertion elements as well as the nucleotide substitutions. Two pairs of genes from Aotinae and Atelinae are clearly orthologous to human leukocyte antigen (HLA) -E and -F genes. Of the remaining 14 genes, 8 belong to the distinct group B, together with HLA-B and -C, to the exclusion of all other HLA class I genes. These NWM genes are classified into four groups, designated as NWM-B1, -B2, -B3, and -B4. Of these, NWM-B2 is orthologous to HLA-B/C. Also, orthologous relationships of NWM-B1, -B2, and -B3 exist among different families of Cebidae and Atelidae, which is in sharp contrast to the genus-specific gene organization within the subfamily Callitrichinae. The other six genes belong to the distinct group G. However, a clade of these NWM genes is almost equally related to HLA-A, -J, -G, and -K, and there is no evidence for their orthologous relationships to HLA-G. It is argued that class I genes in simian primates duplicated extensively in their common ancestral lineage and that subsequent evolution in descendant species has been facilitated mainly by independent loss of genes.

Gene organization of the quail major histocompatibility complex ( MhcCoja ) class I gene region

1999 ◽  
Vol 49 (5) ◽  
pp. 384-394 ◽  
Author(s):  
Takashi Shiina ◽  
Chiori Shimizu ◽  
Akira Oka ◽  
Yoshika Teraoka ◽  
Tadashi Imanishi ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Gene Organization ◽  
Class I ◽  
Gene Region ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
I Gene
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