Selective Antitumor Activity of T-2 Toxin-Antibody Conjugates

1990 ◽  
pp. 403-409
Author(s):  
Katsumi Ohtani ◽  
Yoshio Ueno
Keyword(s):  
Antitumor Activity ◽  
Antibody Conjugates

Aminopterin—Monoclonal antibody conjugates: antitumor activity and toxicity

Drug Delivery ◽  
1993 ◽  
Vol 1 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Kenia G. Krauer ◽  
Ron Bell ◽  
Geoffrey A. Pietersz
Keyword(s):  
Monoclonal Antibody ◽  
Antitumor Activity ◽  
Antibody Conjugates

In vitro antitumor activity of 2'-deoxy-5-fluorouridine-monoclonal antibody conjugates

1991 ◽  
Vol 2 (2) ◽  
pp. 96-101 ◽  
Author(s):  
Ada Goerlach ◽  
Kenia G. Krauer ◽  
Ian F. C. McKenzie ◽  
Geoffrey A. Pietersz
Keyword(s):  
Monoclonal Antibody ◽  
Antitumor Activity ◽  
Antibody Conjugates

Adriamycin(hydrazone)-antibody conjugates require internalization and intracellular acid hydrolysis for antitumor activity

1991 ◽  
Vol 33 (6) ◽  
pp. 367-374 ◽  
Author(s):  
Gary R. Braslawsky ◽  
Kathleen Kadow ◽  
Jay Knipe ◽  
Kerry McGoff ◽  
Mary Edson ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Acid Hydrolysis ◽  
Antibody Conjugates ◽  
Intracellular Acid

The Application of Ultracryotomy to Immunocytochemistry

1973 ◽  
Vol 31 ◽  
pp. 704-709
Author(s):  
R. G. Painter ◽  
K. T. Tokuyasu ◽  
S. J. Singer
Keyword(s):  
Frozen Sections ◽  
Protein Antigens ◽  
Carbon Coated ◽  
Antibody Conjugates ◽  
Ultrathin Frozen Sections

A technique for localizing intracellular antigens with immunoferritin conjugates directly on ultrathin frozen sections of glutaraldehyde-fixed tissues has been developed. This method overcomes some of the limitations of previously described procedures, since it avoids drastic fixation, dehydration and embedding procedures which could denature many protein antigens.Briefly cells or tissues were fixed with glutaraldehyde (0.5 to 2% for 1 hr), and ultrathin frozen sections were cut and mounted on grids covered with carbon-coated Formvar film by the procedure described previously. Such sections were stained with ferritin-antibody conjugates by methods described elsewhere.

Electron Immunochemical Labeling of Ultrathin Sections of Murine Tumor Viruses and Cell Cultures using the Unlabeled Antibody Enzyme Technique

1976 ◽  
Vol 34 ◽  
pp. 266-267
Author(s):  
W. J. Hamilton
Keyword(s):  
Mammary Tumor ◽  
Leukemia Virus ◽  
Parallel Methods ◽  
Tumor Viruses ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Antibody Conjugates ◽  
Rauscher Leukemia ◽  
Antigen Localization ◽  
Unlabeled Antibody

The study of RNA tumor viruses has been greatly facilitated by the use of immunochemical tagging methods. In the past these methods have been constrained to antibody conjugates with ferritin or peroxidase. In order to avoid the disadvantages of using conjugated antisera, investigators have applied the unlabeled antibody enzyme method of Sternberger to mammary tumor derived mouse cells prior to embedding for electron microscopy. The current study has successfully applied the Sternberger method to virusproducing cells and purified virus pellets after epoxy-embedding and ultrathin sectioning. The results demonstrate the distinct advantages of this “post-embedding” method for viral antigen localization.Purified Rauscher leukemia virus (RLV) and mouse mammary tumor virus (MMTV) were pelleted, fixed in buffered 2% paraformaldehyde and washed thoroughly. These were dehydrated in acetone, infiltrated and embedded in Spurr resin according to common procedures. A tumor derived cell line, Mm5mt, producing MMTV was embedded by parallel methods.

710: TNF-Related Apoptosis Inducing Ligand (TRAIL/APO-2L): A Novel Mechanism for BCG-Induced Antitumor Activity

2004 ◽  
Vol 171 (4S) ◽  
pp. 188-189
Author(s):  
Aaron T. Ludwig ◽  
Jill M. Moore ◽  
Yi Luo ◽  
Xiaohong Chen ◽  
Michael A. O’Donnell ◽  
...  
Keyword(s):  
Antitumor Activity

Antitumor activity of tricin, a flavone isolated from leaves of Casearia arborea (Salicaceae)

2017 ◽  
Author(s):  
P Sartorelli ◽  
A Santos ◽  
C Figueiredo ◽  
J Lago ◽  
M Soares
Keyword(s):  
Antitumor Activity

Adaptive NK cells with decreased antitumor activity are expanded in HBV-associated HCC

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
C Rennert ◽  
C Tauber ◽  
B Zecher ◽  
A Schuch ◽  
M Hofmann ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Nk Cells
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