Down’s Syndrome and Alzheimer’s Disease: Are Common Genes From Human Chromosome 21 Involved In Both Disorders?

1986 ◽  
pp. 271-283 ◽  
Author(s):  
Y. Groner ◽  
N. Dafni ◽  
L. Sherman ◽  
D. Levanon ◽  
Y. Bernstein ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Chromosome ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Chromosome 21 ◽  
Human Chromosome 21

Down's syndrome and dementia

2004 ◽  
Vol 10 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Lisa R. Stanton ◽  
Rikus H. Coetzee
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Disorder ◽  
Down's Syndrome ◽  
Acetylcholinesterase Inhibitors ◽  
Down’S Syndrome ◽  
Chromosome 21 ◽  
Unique Challenge ◽  
Increased Risk ◽  
New Treatments

Down's syndrome is the most common genetic disorder seen in clinical practice: about 94% occurs because of non-disjunction of chromosome 21 and 3–5% because of translocation. Individuals increasingly survive to middle and old age, probably because of advances in medical treatment and improved living conditions. People with Down's syndrome have an increased risk of developing Alzheimer's disease in middle age. Within ICD–10 and DSM–IV classifications there is no consensus on the diagnosis of dementia in people with learning disability. New treatments have been licensed for use in mild to moderate Alzheimer's disease (e.g. acetylcholinesterase inhibitors and memantine). The comorbid picture of Down's syndrome and Alzheimer's disease presents a unique challenge to the clinician in both diagnosis and management.

scholarly journals Characterization of monomeric and soluble aggregated Aβ in Down’s syndrome and Alzheimer’s disease brains

2021 ◽  
Vol 754 ◽  
pp. 135894
Author(s):  
Eleni Gkanatsiou ◽  
Charlotte Sahlin ◽  
Erik Portelius ◽  
Malin Johannesson ◽  
Linda Söderberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down's Syndrome ◽  
Down’S Syndrome

scholarly journals Characterization of monomeric and soluble aggregated Aβ in Down’s syndrome and Alzheimer’s disease brains

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Eleni Gkanatsiou ◽  
Charlotte Sahlin ◽  
Erik Portelius ◽  
Malin Johannesson ◽  
Linda Söderberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down's Syndrome ◽  
Down’S Syndrome
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