New Approaches to the Pathology of Breast Cancer; Can Immunohistochemistry Add New Information?

1986 ◽  
pp. 97-111
Author(s):  
PH. Hageman ◽  
J. L. Peterse
Keyword(s):  
Breast Cancer ◽  
New Approaches ◽  
New Information

scholarly journals New approaches for improving outcomes in breast cancer in Europe

The Breast ◽  
2015 ◽  
Vol 24 (4) ◽  
pp. 321-330 ◽  
Author(s):  
Angelo Di Leo ◽  
Giuseppe Curigliano ◽  
Véronique Diéras ◽  
Luca Malorni ◽  
Christos Sotiriou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
New Approaches

Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer

2020 ◽  
Vol 14 (16) ◽  
pp. 1537-1552
Author(s):  
Flavia R Mangone ◽  
Maira AV Valoyes ◽  
Renan G do Nascimento ◽  
Mércia PF Conceição ◽  
Daniel R Bastos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family Members ◽  
Therapy Response ◽  
In Silico Analysis ◽  
Tissue Microarrays ◽  
Luminal Breast Cancer ◽  
Pleckstrin Homology ◽  
Domain Family ◽  
Luminal A ◽  
New Information

Aim: The PHLDA (pleckstrin homology like domain, family A) gene family encodes proteins capable of inhibiting AKT (serine/threonine kinase) signaling through phosphoinositol binding competition. Results & methodology: Using in silico analysis, we found that Luminal A and B patients' short relapse-free survival was associated with low PHLDA1 or PHLDA3 and high PHLDA2 expression. In a cohort of 393 patients with luminal breast cancer evaluated by immunohistochemistry on tissue microarrays, we found a direct association of PHLDA3 expression with hormonal therapy response (p = 0.013). Conclusion: Our findings provide new information on the role played by the PHLDA family members as prognostic markers in breast cancer, and more importantly, we provide evidence that they might also predict a response to endocrine therapy.

scholarly journals Controversies in Breast Cancer

1997 ◽  
Vol 4 (3) ◽  
pp. 226-235 ◽  
Author(s):  
Frank J. Cummings ◽  
Nabil Saba
Keyword(s):  
Breast Cancer ◽  
Clinical Decision Making ◽  
Ductal Carcinoma ◽  
Clinical Decision ◽  
Cancer Management ◽  
New Approaches ◽  
True Value ◽  
Staging Systems ◽  
Breast Cancer Management

Background A large number of controversies about the management of breast cancer produce uncertainties for patients and physicians alike. In addition, questions are constantly raised about the true value of new approaches or treatments. Methods The authors have conducted a critical review of the literature on several of these issues, and they present a balanced view that can be useful for clinical decision making. Results Although new staging systems for ductal carcinoma in situ have been proposed, a consensus has not yet been reached regarding the criteria to allow tumor excision alone. The extent of benefit of the main adjuvant therapies is becoming better established, and improvement in outcomes may accrue from dose-intensive treatments and autologous stem cell or hematopoietic growth factor support. Conclusions Progress in breast cancer management continues to evolve. Several new approaches either reduce morbidity or improve outcomes.

VESSEL-BASED DISPERSANT APPLICATION: NEW APPROACHES, EQUIPMENT, AND LOGISTICS

2001 ◽  
Vol 2001 (2) ◽  
pp. 1195-1201
Author(s):  
Sy Ross ◽  
Randy Belore ◽  
Ken Trudel
Keyword(s):  
Environmental Research ◽  
New Approaches ◽  
Application Systems ◽  
New Information

ABSTRACT The paper consolidates the findings of a number of projects recently completed at S.L. Ross Environmental Research Ltd. that provide new information on dispersant use, particularly in the area of vessel-based application systems. Included are discussions of: (1) various advantages that vessel-based systems have over aircraft-based systems in certain spill situations; (2) comparison of application platforms over a range of spill scenarios; (3) recent research on single-nozzle dispersant application systems for use on vessels; and (4) a recent study showing the potential inefficiencies associated with the application of popular modern dispersants in diluted form.

Primary Systemic Therapy in Breast Cancer: Past Lessons and New Approaches

2008 ◽  
Vol 26 (10) ◽  
pp. 1052-1059 ◽  
Author(s):  
Christina I. Herold ◽  
P. Kelly Marcom
Keyword(s):  
Breast Cancer ◽  
Systemic Therapy ◽  
Primary Systemic Therapy ◽  
New Approaches

scholarly journals Design and Implementation of a Fuzzy Expert System for Diagnosing Breast Cancer

2019 ◽  
pp. 1-14 ◽  
Author(s):  
F. M. Okikiola ◽  
E. E. Aigbokhan ◽  
A. M. Mustapha ◽  
I. O. Onadokun ◽  
O. A. Akinade
Keyword(s):  
Breast Cancer ◽  
Expert System ◽  
Fuzzy Inference ◽  
Treatment Recommendation ◽  
Fuzzy Expert System ◽  
Cancer Type ◽  
Inference System ◽  
Java Programming ◽  
New Information ◽  
High Level

The death rate is caused by breast cancer in women is increasingly high and growing. A number of people are getting to lose this part of their body due to late diagnosis of this disease. This therefore requires the development of an efficient and accurate diagnosis approach that will aid providing the knowledge of the type of breast cancer type and severity in order to reduce the mortality rate through the disease. This need serves as the major motivation for this work. In this paper, we proposed a fuzzy expert system for diagnosis of and treatment recommendation of breast cancer problems which provide physicians and patients with information of the cancer type and treatment recommendation. The application was designed using JAVA programming language, MATLAB and SQLite database engine. This application permits update of new information as a means of knowledge. The evaluation showed that the inclusion of the fuzzy inference system improved the accuracy and precision of the system from 0.8 to 0.9. The system is user-friendly and has high level of acceptability from the validation conducted at the end of the research.

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