Germ and somatic cell interactions during gonadal morphogenesis

1984 ◽  
pp. 19-30 ◽  
Author(s):  
Horacio Merchant-Larios
2004 ◽  
Vol 82-83 ◽  
pp. 431-446 ◽  
Author(s):  
R.B Gilchrist ◽  
L.J Ritter ◽  
D.T Armstrong

1989 ◽  
Vol 40 (2) ◽  
pp. 317-331 ◽  
Author(s):  
Luyuan Li ◽  
Andrew P. Seddon ◽  
Alton Meister ◽  
Michael S. Risley

1980 ◽  
Vol 16 (8) ◽  
pp. 1047-1051 ◽  
Author(s):  
P.J. Higgins ◽  
E. Borenfreund ◽  
M.Z. Wahrman ◽  
A. Bendich

2005 ◽  
pp. 317-328 ◽  
Author(s):  
Michael K. Skinner

Author(s):  
Patrícia Rodrigues ◽  
Darlene Limback ◽  
Lynda McGinnis ◽  
Mónica Marques ◽  
Juan Aibar ◽  
...  

Mammalian females are born with a finite reserve of ovarian follicles, the functional units of the ovary. Building an ovarian follicle involves a complex interaction between multiple cell types, of which the oocyte germ cell and the somatic granulosa cells play a major role. Germ–somatic cell interactions are modulated by factors of different cell origins that influence ovarian development. In early development, failure in correct germ–somatic cell communication can cause abnormalities in ovarian development. These abnormalities can lead to deficient oocyte differentiation, to a diminished ovarian follicle reserve, and consequently to early loss of fertility. However, oocyte–granulosa cell communication is also extremely important for the acquisition of oocyte competence until ovulation. In this paper, we will visit the establishment of follicle reserve, with particular emphasis in germ–somatic cell interactions, and their importance for human fertility.


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