Oocyte–somatic cell interactions during follicle development in mammals

2004 ◽  
Vol 82-83 ◽  
pp. 431-446 ◽  
Author(s):  
R.B Gilchrist ◽  
L.J Ritter ◽  
D.T Armstrong
Keyword(s):  
Somatic Cell ◽  
Cell Interactions ◽  
Follicle Development

Hormonal control of somatic cell oocyte interactions during ovarian follicle development

2004 ◽  
Vol 69 (3) ◽  
pp. 347-355 ◽  
Author(s):  
Catherine M.H. Combelles ◽  
Mary Jo Carabatsos ◽  
T. Rajendra Kumar ◽  
Martin M. Matzuk ◽  
David F. Albertini
Keyword(s):  
Somatic Cell ◽  
Ovarian Follicle ◽  
Hormonal Control ◽  
Follicle Development ◽  
Ovarian Follicle Development

Follicular somatic cell factors and follicle development

2011 ◽  
Vol 23 (1) ◽  
pp. 32 ◽  
Author(s):  
J. Buratini ◽  
C. A. Price
Keyword(s):  
Somatic Cell ◽  
Granulosa Cell ◽  
Bone Morphogenetic Proteins ◽  
Granulosa Cells ◽  
Primordial Follicle ◽  
Antral Follicle ◽  
Follicle Development ◽  
Follicle Growth ◽  
Theca Cells ◽  
Secreted Factors

Considerable attention is currently paid to oocyte-derived secreted factors that act upon cumulus and granulosa cells. Also important for follicle development are somatic cell-derived secreted factors. This is illustrated by the ability of granulosa cell-derived Kit ligand (KITL) to promote primordial follicle activation, and the loss of follicle development that accompanies KITL gene disruption. This review summarises our current understanding of somatic cell factors during both preantral and antral follicle growth, involving not only signalling from granulosa cells to the oocyte, but also signalling between granulosa and theca cells. Principal granulosa cell-derived factors include activin, anti-Müllerian hormone (AMH), bone morphogenetic proteins (BMPs) and fibroblast growth factors (FGFs). Theca cells also secrete BMPs and FGFs. The interplay between these factors is equally important for follicle growth as the activity of oocyte-derived factors.

scholarly journals Glial-derived neurotrophic factor promotes ovarian primordial follicle development and cell–cell interactions during folliculogenesis

Reproduction ◽  
2008 ◽  
Vol 135 (5) ◽  
pp. 671-682 ◽  
Author(s):  
Gretchen Dole ◽  
Eric E Nilsson ◽  
Michael K Skinner
Keyword(s):  
Microarray Analysis ◽  
Granulosa Cells ◽  
Neurotrophic Factor ◽  
Primordial Follicle ◽  
Cell Interactions ◽  
Follicle Development ◽  
Antral Follicles ◽  
Theca Cells ◽  
Oocyte Cytoplasm ◽  
Cell Cell

Female fertility is determined in part by the size and development of the primordial follicle pool. The current study investigates the role of glial cell-line-derived neurotrophic factor (GDNF) in the regulation of primordial follicle development in the ovary. Ovaries from 4-day-old female rat pups were maintained in organ culture for 10 days in the absence (control) or presence of GDNF or kit ligand (KL)/stem cell factor. Ovaries treated with GDNF contained a significant increase in developing follicles, similar to that observed with KL treatment previously shown to promote follicle development. The actions of GDNF on the ovarian transcriptome were investigated with a microarray analysis. Immunohistochemical studies demonstrated that GDNF is localized to oocyte cytoplasm in follicles of all developmental stages, as well as to cumulus granulosa cells and theca cells in antral follicles. GDNF receptor α1 (GFRα1) staining was localized to oocyte cytoplasm of primordial and primary follicles, and at reduced levels in the oocytes of antral follicles. GFRα1 was present in mural granulosa cells of antral follicles, theca cells, and ovarian surface epithelium. The localization studies were confirmed with molecular analysis. Microarray analysis was used to identify changes in the ovarian transcriptome and further elucidate the signaling network regulating early follicle development. Observations indicate that GDNF promotes primordial follicle development and mediates autocrine and paracrine cell–cell interactions required during folliculogenesis. In contrast to the testis, ovarian GDNF is predominantly produced by germ cells (oocytes) rather than somatic cells.

scholarly journals Spermatogenic Cell-Somatic Cell Interactions are Required for Maintenance of Spermatogenic Cell Glutathione1

1989 ◽  
Vol 40 (2) ◽  
pp. 317-331 ◽  
Author(s):  
Luyuan Li ◽  
Andrew P. Seddon ◽  
Alton Meister ◽  
Michael S. Risley
Keyword(s):  
Somatic Cell ◽  
Cell Interactions ◽  
Spermatogenic Cell

In Vitro consequences of sperm-somatic cell interactions

1980 ◽  
Vol 16 (8) ◽  
pp. 1047-1051 ◽  
Author(s):  
P.J. Higgins ◽  
E. Borenfreund ◽  
M.Z. Wahrman ◽  
A. Bendich
Keyword(s):  
Somatic Cell ◽  
Cell Interactions
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