Mucus-Producing Cells of the Tracheobronchial Tree

Author(s):  
Barbara Meyrick
2015 ◽  
Author(s):  
Amir A. Mofakham ◽  
Lin Tian ◽  
Goodarz Ahmadi

Transport and deposition of micro and nano-particles in the upper tracheobronchial tree were analyzed using a multi-level asymmetric lung bifurcation model. The multi-level lung model is flexible and computationally efficient by fusing sequence of individual bifurcations with proper boundary conditions. Trachea and the first two generations of the tracheobronchial airway were included in the analysis. In these regions, the airflow is in turbulent regime due to the disturbances induced by the laryngeal jet. Anisotropic Reynolds stress transport turbulence model (RSTM) was used for mean the flow simulation, together with the enhanced two-layer model boundary conditions. Particular attention is given to evaluate the importance of the “quadratic variation of the turbulent fluctuations perpendicular to the wall” on particle deposition in the upper tracheobroncial airways.


2021 ◽  
pp. 106689692110022
Author(s):  
Jenny L. Weon ◽  
Stephen Megison ◽  
Charles F. Timmons ◽  
Dinesh Rakheja

We describe a previously unreported bronchopulmonary foregut malformation wherein a segment of a bronchus of the lower lobe of the left lung in a 4-year-old girl was entirely esophageal in structure. No communication was identified between the tracheobronchial tree and the esophagus by radiologic examination or at surgery. The esophagus-like bronchus was associated with an adjacent atretic bronchus and a downstream cavity in the lower lobe of the left lung. The child sought clinical attention because of recurrent pulmonary infections localized to the lower lobe of the lung. We posit that this esophagus-like bronchus is a novel noncommunicating bronchopulmonary foregut malformation.


Respiration ◽  
2021 ◽  
pp. 1-5
Author(s):  
Erik E. Folch ◽  
Catherine L. Oberg ◽  
Atul C. Mehta ◽  
Adnan Majid ◽  
Colleen Keyes ◽  
...  

<b><i>Background:</i></b> Argon plasma coagulation (APC) is a tool used in the management of tracheobronchial obstruction or bleeding. Complications include gas embolism which can cause devastating effects including hemodynamic instability, cardiac arrest, and stroke. Multiple theories as to how gas embolism occurs with APC have been postulated; however, none have identified the exact mechanism. <b><i>Objectives:</i></b> To identify the mechanism by which APC causes gas embolism in the tracheobronchial tree. <b><i>Methods:</i></b> Using an explanted porcine tracheobronchial tree with lung parenchyma, the APC catheter was applied through noncontact and direct contact to the endobronchial airway mucosa via flexible bronchoscopy. This was done at multiple gas flow settings and pulse durations. Visual changes in the mucosa were photographed, videoed, and described. <b><i>Results:</i></b> Gross evidence of submucosal gas transfer occurred when the APC catheter was in direct contact with the mucosa at all gas flow settings in all applications, despite using shorter pulse durations. Whenever the catheter was not in contact with the mucosa, there was no transfer of gas at any gas flow setting or pulse duration. <b><i>Conclusions:</i></b> Direct mucosal contact with the APC probe leads to submucosal gas deposition and is a likely mechanism for gas entry into the intravascular space. In reported cases of APC-associated gas embolism, presence of a vascularized endobronchial tumor may have increased the risk of gas tracking into the intravascular space. Care should be taken when applying APC during brisk bleeding or limited vision, as inadvertent mucosal contact may occur and could increase the risk of gas embolism.


1969 ◽  
Vol 8 (6) ◽  
pp. 542-560 ◽  
Author(s):  
Don R. Miller

2016 ◽  
Vol 54 (2) ◽  
pp. 116-120 ◽  
Author(s):  
Levent Dalar ◽  
Cengiz Özdemir ◽  
Sinem Nedime Sökücü ◽  
Levent Karasulu ◽  
Sedat Altın

2002 ◽  
Vol 16 (2) ◽  
pp. 260-261 ◽  
Author(s):  
Vanna Soonthon-Brant ◽  
Jonathan L. Benumof

1980 ◽  
Vol 42 (6) ◽  
pp. 847-859 ◽  
Author(s):  
Wen-Jia Russell Chen ◽  
David Shii-Pyng Shiah ◽  
C. S. Wang

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