Psychoneuroimmune Phenomena: Neuroimmune Interactions

2021 ◽  
pp. 1-29
Author(s):  
Robert Dantzer
Keyword(s):  
Neuroimmune Interactions

Neuroimmune interactions in painful TMD: Mechanisms and treatment implications

2021 ◽  
Author(s):  
Yating Yi ◽  
Xueman Zhou ◽  
Xin Xiong ◽  
Jun Wang
Keyword(s):  
Neuroimmune Interactions

Endocannabinoid system: Role in blood cell development, neuroimmune interactions and associated disorders

2021 ◽  
Vol 353 ◽  
pp. 577501
Author(s):  
Durga Shankar Sharma ◽  
Indira Paddibhatla ◽  
Sanjeev Raghuwanshi ◽  
Mahesh Malleswarapu ◽  
Anjali Sangeeth ◽  
...  
Keyword(s):  
Blood Cell ◽  
Endocannabinoid System ◽  
Cell Development ◽  
Neuroimmune Interactions

Neuroimmune interactions and immunoengineering strategies in peripheral nerve repair

2021 ◽  
pp. 102172
Author(s):  
Kathryn L. Wofford ◽  
Robert B. Shultz ◽  
Justin C. Burrell ◽  
D. Kacy Cullen
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair ◽  
Neuroimmune Interactions

Targeting Neuroimmune Interactions in Diabetic Neuropathy with Nanomedicine

2021 ◽  
Author(s):  
Mihály Balogh ◽  
Jelena M Janjic ◽  
Andrew John Shepherd
Keyword(s):  
Diabetic Neuropathy ◽  
Neuroimmune Interactions

The modulating role of histamine in neuroimmune interactions

2021 ◽  
Vol 19 (3) ◽  
pp. 17-26
Author(s):  
Elena Yurievna Bystrova ◽  
Kristina Alekseevna Dvornikova ◽  
Olga Nikolaevna Platonova ◽  
Alexander Danilovich Nozdrachev
Keyword(s):  
Neuroimmune Interactions

scholarly journals Cutaneous Neuroimmune Interactions of TSLP and TRPV4 Play Pivotal Roles in Dry Skin-Induced Pruritus

2021 ◽  
Vol 12 ◽  
Author(s):  
Wook-Joo Lee ◽  
Won-Sik Shim
Keyword(s):  
Mast Cells ◽  
Dorsal Root ◽  
Transient Receptor Potential ◽  
Skin Barrier ◽  
Receptor Potential ◽  
Barrier Dysfunction ◽  
Dry Skin ◽  
Neuroimmune Interactions ◽  
Skin Conditions ◽  
Transient Receptor

Dry skin is a symptom of skin barrier dysfunction that evokes pruritus; however, the cutaneous neuroimmune interactions underlying dry skin-induced pruritus remain unclear. Therefore, we aimed to elucidate the mechanisms underlying dry skin-induced pruritus. To this end, an acetone/ethanol/water (AEW)-induced mouse model of dry skin was used in this study. We observed that the production of thymic stromal lymphopoietin (TSLP) significantly increased in the keratinocytes of AEW mice. Importantly, treatment with an antagonist of transient receptor potential cation channel subfamily V member 4 (TRPV4), HC067047, ameliorated dry skin conditions in AEW mice. The symptoms of dry skin were significantly reduced in Trpv4 knockout (KO) mice following treatment with AEW. The increase in the intracellular calcium levels by TSLP in the dorsal root ganglia (DRG) of Trpv4 KO mice was also significantly attenuated. The spontaneous scratching bouts were significantly decreased in both the HC067047-treated and Trpv4 KO AEW mice. Importantly, the TSLP-dependent release of tryptase from the mast cells was significantly reduced in both the HC067047-treated mice and Trpv4 KO AEW mice. Notably, inhibition of the TSLP-induced signaling pathway in DRG selectively reduced the spontaneous scratching bouts in AEW mice. Overall, the results demonstrated that the cutaneous neuroimmune interactions of TSLP and TRPV4 play pivotal roles in dry skin-induced pruritus.

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