Regulation of the Rod Photoreceptor Cyclic Nucleotide-Gated Channel

2002 ◽  
pp. 205-223 ◽  
Author(s):  
René Warren ◽  
Robert S. Molday
Keyword(s):  
Cyclic Nucleotide ◽  
Rod Photoreceptor ◽  
Gated Channel

scholarly journals A 240 kDa protein represents the complete β subunit of the cyclic nucleotide-gated channel from rod photoreceptor

Neuron ◽  
1995 ◽  
Vol 15 (3) ◽  
pp. 627-636 ◽  
Author(s):  
Heinz Gerd Ko¨rschen ◽  
Michelle Illing ◽  
Reinhard Seifer ◽  
Federico Sesti ◽  
Andrew Williams ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Rod Photoreceptor ◽  
Β Subunit ◽  
Gated Channel

scholarly journals Ankyrin-G Promotes Cyclic Nucleotide-Gated Channel Transport to Rod Photoreceptor Sensory Cilia

Science ◽  
2009 ◽  
Vol 323 (5921) ◽  
pp. 1614-1617 ◽  
Author(s):  
K. Kizhatil ◽  
S. A. Baker ◽  
V. Y. Arshavsky ◽  
V. Bennett
Keyword(s):  
Cyclic Nucleotide ◽  
Rod Photoreceptor ◽  
Ankyrin G ◽  
Channel Transport ◽  
Sensory Cilia ◽  
Gated Channel

scholarly journals Systemic administration of ivabradine, a hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, blocks spontaneous absence seizures

Epilepsia ◽  
2021 ◽  
Author(s):  
Yasmine Iacone ◽  
Tatiana P. Morais ◽  
François David ◽  
Francis Delicata ◽  
Joanna Sandle ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Systemic Administration ◽  
Absence Seizures ◽  
Gated Channel

Expression of the olfactory cyclic nucleotide gated channel (CNG1) in the rat brain

Neuroreport ◽  
1995 ◽  
Vol 6 (10) ◽  
pp. 1459-1463 ◽  
Author(s):  
Alaa El-Din El-Husseini ◽  
Christopher Bladen ◽  
Steven R. Vincent
Keyword(s):  
Rat Brain ◽  
Cyclic Nucleotide ◽  
Gated Channel

Impaired Opsin Targeting and Cone Photoreceptor Migration in the Retina of Mice Lacking the Cyclic Nucleotide-Gated Channel CNGA3

2005 ◽  
Vol 46 (4) ◽  
pp. 1516 ◽  
Author(s):  
Stylianos Michalakis ◽  
Heidi Geiger ◽  
Silke Haverkamp ◽  
Franz Hofmann ◽  
Andrea Gerstner ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Cone Photoreceptor ◽  
Gated Channel

Divalent cations block the cyclic nucleotide-gated channel of olfactory receptor neurons

1993 ◽  
Vol 69 (5) ◽  
pp. 1758-1768 ◽  
Author(s):  
F. Zufall ◽  
S. Firestein
Keyword(s):  
Cyclic Amp ◽  
Calcium Channels ◽  
Cyclic Nucleotide ◽  
Olfactory Receptor ◽  
Single Channel ◽  
Divalent Cations ◽  
Olfactory Receptor Neurons ◽  
Gated Channel ◽  
Receptor Neurons ◽  
Single Channel Currents

1. The effects of external divalent cations on odor-dependent, cyclic AMP-activated single-channel currents from olfactory receptor neurons of the tiger salamander (Ambystoma tigrinum) were studied in inside-out membrane patches taken from dendritic regions of freshly isolated sensory cells. 2. Channels were reversibly activated by 100 microM cyclic AMP. In the absence of divalent cations, the channel had a linear current-voltage relation giving a conductance of 45 pS. With increasing concentrations of either Ca2+ or Mg2+ in the external solution, the channel displayed a rapid flickering behavior. At higher concentrations of divalent cations, the transitions were too rapid to be fully resolved and appeared as a reduction in mean unitary single-channel current amplitude. 3. This effect was voltage dependent, and on analysis was shown to be due to an open channel block by divalent ions. In the case of Mg2+, the block increased steadily with hyperpolarization. In contrast, for Ca2+ the block first increased with hyperpolarization and then decreased with further hyperpolarization beyond -70 mV, providing evidence for Ca2+ permeation of this channel. 4. This block is similar to that seen in voltage-gated calcium channels. Additionally, the cyclic nucleotide-gated channel shows some pharmacological similarities with L-type calcium channels, including a novel block of the cyclic nucleotide channel by nifedipine (50 microM). 5. Our results indicate that the sensory generator current simultaneously depends on the presence of the second messenger and on the membrane potential of the olfactory neuron.

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