Luria-Nebraska Neuropsychological Battery

Abstract Objective To examine the factor structure and sociodemographic correlates of a battery of clinical neuropsychological tests administered in-home and via telephone. Method Participants included 280 healthy adults who completed a 35–40 min battery consisting of seven auditory-verbal neuropsychological tests (i.e., 10 variables) that included digit span, list learning and memory, prospective memory, verbal fluency, and oral trail making. Results After removing oral trail making part A, a three-factor model comprised of executive functions, memory and attention demonstrated the best fit to the data. Nevertheless, the shared variance between the nine remaining neuropsychological variables was also adequately explained by a single-factor model and a two-factor model comprised of executive functions and memory. Factor scores were variably associated with education, race/ethnicity, and IQ, but not with sex or age. Conclusions Findings provide preliminary support for the feasibility and factor structure and sociodemographic correlates of a brief telephone-based screening neuropsychological battery comprised mostly of commonly administered clinical measures. Future studies are needed to determine the test–retest reliability, sensitivity, and ecological relevance of this battery, as well as equivalency to in-person assessment.

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Cerebral Perfusion in Hemodialysis Patients: A Feasibility Study

Canadian Journal of Kidney Health and Disease ◽

10.1177/20543581211010654 ◽

2021 ◽

Vol 8 ◽

pp. 205435812110106

Author(s):

Jessica Anne Vanderlinden ◽

Rachel Mary Holden ◽

Stephen Harold Scott ◽

John Gordon Boyd

Keyword(s):

Cerebral Oxygenation ◽

Capture Rate ◽

Data Capture ◽

Dialysis Initiation ◽

Trial Registration ◽

Neuropsychological Battery ◽

Consent Rate ◽

Dialysis Unit ◽

Individual Level ◽

High Data

Background: Patients on hemodialysis (HD) are known to exhibit low values of regional cerebral oxygenation (rSO2) and impaired cognitive functioning. The etiology of both is currently unknown. Objective: To determine the feasibility of serially monitoring rSO2 in patients initiating HD. In addition, we sought to investigate how rSO2 is related to hemodynamic and dialysis parameters. Design: Prospective observational study. Setting: Single-center tertiary academic teaching hospital in Ontario, Canada. Participants: Six patients initiating HD were enrolled in the study. Methods: Feasibility was defined as successful study enrollment (>1 patient/month), successful consent rate (>70%), high data capture rates (>90%), and assessment tolerability. Regional cerebral oxygenation monitoring was performed 1 time/wk for the first year of dialysis. A neuropsychological battery was performed 3 times during the study: before dialysis initiation, 3 months, and 1 year after dialysis initiation. The neuropsychological battery included a traditional screening tool: the Repeatable Battery for the Assessment of Neuropsychological Status, and a robot-based assessment: Kinarm. Results: Our overall consent rate was 33%, and our enrollment rate was 0.4 patients/mo. In total 243 rSO2 sessions were recorded, with a data capture rate of 91.4% (222/243) across the 6 patients. Throughout the study, no adverse interactions were reported. Correlations between rSO2 with hemodynamic and dialysis parameters showed individual patient variability. However, at the individual level, all patients demonstrated positive correlations between mean arterial pressure and rSO2. Patients who had more than 3 liters of fluid showed significant negative correlations with rSO2. Less cognitive impairment was detected after initiating dialysis. Limitation: This small cohort limits conclusions that can be made between rSO2 and hemodynamic and dialysis parameters. Conclusions: Prospectively monitoring rSO2 in patients was unfeasible in a single dialysis unit, due to low consent and enrollment rates. However, rSO2 monitoring may provide unique insights into the effects of HD on cerebral oxygenation that should be further investigated. Trial Registration: Due to the feasibility nature of this study, no trial registration was performed.

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Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI

Journal of the International Neuropsychological Society ◽

10.1017/s135561770808079x ◽

2008 ◽

Vol 14 (4) ◽

pp. 582-590 ◽

Cited By ~ 25

Author(s):

ARTO NORDLUND ◽

SINDRE ROLSTAD ◽

OLA KLANG ◽

KARIN LIND ◽

MONA PEDERSEN ◽

...

Keyword(s):

Episodic Memory ◽

Neuropsychological Battery ◽

Prodromal Stage ◽

Age Norms ◽

Total Tau ◽

Prodromal Ad ◽

Function Language ◽

T Tau ◽

Normal Controls ◽

Better Than

Mild cognitive impairment (MCI) is regarded as the prodromal stage of dementia disorders, such as Alzheimer's disease (AD).Objective: To compare the neuropsychological profiles of MCI subjects with normal concentrations of total tau (T-τ) and Aβ42 in CSF (MCI-norm) to MCI subjects with deviating concentrations of the biomarkers (MCI-dev). MCI-norm (N = 73) and MCI-dev (N = 73) subjects were compared to normal controls (N = 50) on tests of speed/attention, memory, visuospatial function, language and executive function.Results: MCI-norm performed overall better than MCI-dev, specifically on tests of speed and attention and episodic memory. When MCI-dev subjects were subclassified into those with only high T-tau (MCI-tau), only low Aβ42 (MCI-Aβ) and both high T-tau and low Aβ42 (MCI-tauAβ), MCI-tauAβ tended to perform slightly worse. MCI-tau and MCI-Aβ performed quite similarly.Conclusions: Considering the neuropsychological differences, many MCI-norm probably had more benign forms of MCI, or early non-AD forms of neurodegenerative disorders. Although most MCI-dev performed clearly worse than MCI-norm on the neuropsychological battery, some did not show any deficits when compared to age norms. A combination of CSF analyses and neuropsychology could be a step toward a more exact diagnosis of MCI as prodromal AD. (JINS, 2008, 14, 582–590.)

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Test-Retest Reliability of the Clinical, Factor, and Localization Scales of the Luria-Nebraska Neuropsychological Battery

International Journal of Neuroscience ◽

10.3109/00207458208985919 ◽

1982 ◽

Vol 17 (3) ◽

pp. 163-167 ◽

Cited By ~ 11

Author(s):

James R. Plaisted ◽

Charles J. Golden

Keyword(s):

Neuropsychological Battery ◽

Clinical Factor ◽

Retest Reliability ◽

Test Retest Reliability

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Age, gender, and education norms on the CERAD neuropsychological battery in the oldest old

Neurology ◽

10.1212/01.wnl.0000237548.15734.cd ◽

2006 ◽

Vol 67 (6) ◽

pp. 1006-1010 ◽

Cited By ~ 65

Author(s):

M. S. Beeri ◽

J. Schmeidler ◽

M. Sano ◽

J. Wang ◽

R. Lally ◽

...

Keyword(s):

Oldest Old ◽

Neuropsychological Battery ◽

Gender And Education

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Normative scores on the Luria-Nebraska neuropsychological battery

Archives of Clinical Neuropsychology ◽

10.1093/arclin/5.2.203a ◽

1990 ◽

Vol 5 (2) ◽

pp. 203-203

Author(s):

A. E. Puente ◽

D. A. Brinkley ◽

B. Robert

Keyword(s):

Neuropsychological Battery

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Empirical methods for assessing meaningful neuropsychological change following epilepsy surgery

Journal of the International Neuropsychological Society ◽

10.1017/s1355617700001739 ◽

1996 ◽

Vol 2 (6) ◽

pp. 556-564 ◽

Cited By ~ 158

Author(s):

Stephen M. Sawrie ◽

Gordon J. Chelune ◽

Richard I. Naugle ◽

Hans O. Lüders

Keyword(s):

Epilepsy Surgery ◽

Intractable Epilepsy ◽

Practice Effects ◽

Cutoff Score ◽

Regression To The Mean ◽

Neuropsychological Battery ◽

Reliable Change ◽

Medical Interventions ◽

The Mean ◽

Test Retest Reliability

AbstractTraditional methods for assessing the neurocognitive effects of epilepsy surgery are confounded by practice effects, test-retest reliability issues, and regression to the mean. This study employs 2 methods for assessing individual change that allow direct comparison of changes across both individuals and test measures. Fifty-one medically intractable epilepsy patients completed a comprehensive neuropsychological battery twice, approximately 8 months apart, prior to any invasive monitoring or surgical intervention. First, a Reliable Change (RC) index score was computed for each test score to take into account the reliability of that measure, and a cutoff score was empirically derived to establish the limits of statistically reliable change. These indices were subsequently adjusted for expected practice effects. The second approach used a regression technique to establish “change norms” along a common metric that models both expected practice effects and regression to the mean. The RC index scores provide the clinician with a statistical means of determining whether a patient's retest performance is “significantly” changed from baseline. The regression norms for change allow the clinician to evaluate the magnitude of a given patient's change on 1 or more variables along a common metric that takes into account the reliability and stability of each test measure. Case data illustrate how these methods provide an empirically grounded means for evaluating neurocognitive outcomes following medical interventions such as epilepsy surgery. (JINS, 1996, 2, 556–564.)

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