Gene Therapy for Acute Kidney Diseases

2001 ◽  
pp. 159-179
Author(s):  
Enyu Imai ◽  
Yoshitaka Isaka
Keyword(s):  
Gene Therapy ◽  
Kidney Diseases

Application of gene therapy to kidney diseases

1999 ◽  
Vol 3 (3) ◽  
pp. 147-153
Author(s):  
Y. Isaka
Keyword(s):  
Gene Therapy ◽  
Kidney Diseases

scholarly journals Gene therapy research for kidney diseases

2019 ◽  
Vol 51 (9) ◽  
pp. 449-461
Author(s):  
Lori Davis ◽  
Frank Park
Keyword(s):  
Gene Therapy ◽  
Kidney Diseases ◽  
Genetic Diseases ◽  
Standard Of Care ◽  
Symptomatic Treatment ◽  
Medical Intervention ◽  
Current Standard ◽  
Gene Therapy Vector ◽  
Vector Systems ◽  
Organ Systems

A resurgence in the development of newer gene therapy systems has led to recent successes in the treatment of B cell cancers, retinal degeneration and neuromuscular atrophy. Gene therapy offers the ability to treat the patient at the root cause of their malady by restoring normal gene function and arresting the pathological progression of their genetic disease. The current standard of care for most genetic diseases is based upon the symptomatic treatment with polypharmacy while minimizing any potential adverse effects attributed to the off-target and drug-drug interactions on the target or other organs. In the kidney, however, the development of gene therapy modifications to specific renal cells has lagged far behind those in other organ systems. Some positive strides in the past few years provide continued enthusiasm to invest the time and effort in the development of new gene therapy vectors for medical intervention to treat kidney diseases. This mini-review will systematically describe the pros and cons of the most commonly tested gene therapy vector systems derived from adenovirus, retrovirus, and adeno-associated virus and provide insight about their potential utility as a therapy for various types of genetic diseases in the kidney.

Gene Therapy Targeting Kidney Diseases: Routes and Vehicles

2012 ◽  
pp. 267-277 ◽  
Author(s):  
Yoshitaka Isaka ◽  
Yoshitsugu Takabatake ◽  
Hiromi Rakugi
Keyword(s):  
Gene Therapy ◽  
Kidney Diseases

Gene therapy targeting kidney diseases: routes and vehicles

2006 ◽  
Vol 10 (4) ◽  
pp. 229-235 ◽  
Author(s):  
Yoshitaka Isaka
Keyword(s):  
Gene Therapy ◽  
Kidney Diseases

Gene therapy for kidney diseases

2005 ◽  
pp. 161-191
Author(s):  
Sifeng Chen ◽  
Kirsten M. Madsen ◽  
C. Craig Tisher ◽  
Anupam Agarwal
Keyword(s):  
Gene Therapy ◽  
Kidney Diseases

Immunolabelling of glomerular deposits in kidney biopsies routinely fixed in glutaraldehyde

1989 ◽  
Vol 47 ◽  
pp. 910-911
Author(s):  
Ś Lhoták ◽  
I. Alexopoulou ◽  
G. T. Simon
Keyword(s):  
Uv Light ◽  
Kidney Diseases ◽  
Light Chains ◽  
Microscopical Level ◽  
Accurate Identification ◽  
Light Microscopical Level ◽  
Dense Deposits ◽  
Cacodylate Buffer ◽  
Glomerular Deposits ◽  
Prognostic Importance

Various kidney diseases are characterized by the presence of dense deposits in the glomeruli. The type(s) of immunoglobulins (Igs) present in the dense deposits are characteristic of the disease. The accurate Identification of the deposits is therefore of utmost diagnostic and prognostic importance. Immunofluorescence (IF) used routinely at the light microscopical level is unable to detect and characterize small deposits found in early stages of glomerulonephritis. Although conventional TEM is able to localize such deposits, it is not capable of determining their nature. It was therefore attempted to immunolabel at EM level IgG, IgA IgM, C3, fibrinogen and kappa and lambda Ig light chains commonly found in glomerular deposits on routinely fixed ( 2% glutaraldehyde (GA) in 0.1M cacodylate buffer) kidney biopsies.The unosmicated tissue was embedded in LR White resin polymerized by UV light at -10°C. A postembedding immunogold technique was employed

Antiangiogenic gene therapy delays growth of murine and human pancreatic adenocarcinoma in mice

2001 ◽  
Vol 120 (5) ◽  
pp. A349-A349
Author(s):  
J TSENG ◽  
F FARNEBO ◽  
O KISKER ◽  
C BECKER ◽  
C KUO ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Pancreatic Adenocarcinoma ◽  
Human Pancreatic Adenocarcinoma
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