Cyclooxygenese-2 promoter can mittigate the lethal toxicity in HSV-TK based adenoviral suicide gene therapy of gastrointestinal cancers

2001 ◽  
Vol 120 (5) ◽  
pp. A10-A10
Author(s):  
M YAMAMOTO ◽  
R ALEMANY ◽  
Y ADACHI ◽  
W GRIZZLE ◽  
D CURIEL
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Gastrointestinal Cancers ◽  
Lethal Toxicity

Cyclooxygenese-2 promoter can mittigate the lethal toxicity in HSV-TK based adenoviral suicide gene therapy of gastrointestinal cancers

2001 ◽  
Vol 120 (5) ◽  
pp. A10
Author(s):  
Masato Yamamoto ◽  
Ramon Alemany ◽  
Yasuo Adachi ◽  
Willium E. Grizzle ◽  
David T. Curiel
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Gastrointestinal Cancers ◽  
Lethal Toxicity

scholarly journals Characterization of the Cyclooxygenase-2 Promoter in an Adenoviral Vector and Its Application for the Mitigation of Toxicity in Suicide Gene Therapy of Gastrointestinal Cancers

2001 ◽  
Vol 3 (3) ◽  
pp. 385-394 ◽  
Author(s):  
Masato Yamamoto ◽  
Ramon Alemany ◽  
Yasuo Adachi ◽  
William E. Grizzle ◽  
David T. Curiel
Keyword(s):  
Gene Therapy ◽  
Adenoviral Vector ◽  
Suicide Gene ◽  
Cyclooxygenase 2 ◽  
Suicide Gene Therapy ◽  
Gastrointestinal Cancers

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment

2020 ◽  
Vol 3 (8) ◽  
pp. 2000007
Author(s):  
Lucia Salvioni ◽  
Stefania Zuppone ◽  
Francesco Andreata ◽  
Matteo Monieri ◽  
Serena Mazzucchelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Cancer Treatment ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Suicide Gene ◽  
Breast Cancer Treatment ◽  
Suicide Gene Therapy

scholarly journals Development of iRGD-Modified Peptide Carriers for Suicide Gene Therapy of Uterine Leiomyoma

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 202
Author(s):  
Anna Egorova ◽  
Sofia Shtykalova ◽  
Alexander Selutin ◽  
Natalia Shved ◽  
Marianna Maretina ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Uterine Leiomyoma ◽  
Transfection Efficiency ◽  
Chemical Properties ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Benign Tumors ◽  
Αvβ3 Integrin ◽  
Peptide Carrier ◽  
Plasmid Delivery

Uterine leiomyoma (UL) is one of the most common benign tumors in women that often leads to many reproductive complications. Suicide genetherapy was suggested as a promising approach for UL treatment. In the present study, we describe iRGD ligand-conjugated cysteine-rich peptide carrier RGD1-R6 for targeted DNA delivery to αvβ3 integrin-expressing primary UL cells. The physico-chemical properties, cytotoxicity, transfection efficiency and specificity of DNA/RGD1-R6 polyplexes were investigated. TheHSV-1thymidine kinase encoding plasmid delivery to PANC-1pancreatic carcinoma cells and primary UL cells resulted in significant suicide gene therapy effects. Subsequent ganciclovir treatment decreased cells proliferative activity, induced of apoptosis and promoted cells death.The obtained results allow us to concludethatthe developed RGD1-R6 carrier can be considered a promising candidate for suicide gene therapy of uterine leiomyoma.

Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene

Surgery ◽  
1998 ◽  
Vol 123 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Héléna Nagy ◽  
Yves Panis ◽  
Monique Fabre ◽  
Hubert Perrin ◽  
David Klatzmann ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Experimental Study ◽  
Thymidine Kinase ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Good Target

scholarly journals Monitoring HSVtk suicide gene therapy: the role of [18F]FHPG membrane transport

2004 ◽  
Vol 91 (12) ◽  
pp. 2079-2085 ◽  
Author(s):  
A R Buursma ◽  
I J van Dillen ◽  
A van Waarde ◽  
W Vaalburg ◽  
G A P Hospers ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Membrane Transport ◽  
Suicide Gene ◽  
Suicide Gene Therapy
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