Quantification of Quinolinic Acid Metabolism by Macrophages and Astrocytes

1995 ◽  
pp. 317-325
Author(s):  
Melvyn P. Heyes ◽  
Eugene O. Major ◽  
Kuniaki Sato ◽  
Sanford M. Markey
Keyword(s):  
Quinolinic Acid ◽  
Acid Metabolism

STUDIES OF QUINOLINIC ACID METABOLISM IN RAT BRAIN

1984 ◽  
Vol 7 ◽  
pp. S247 ◽  
Author(s):  
R. Schwarcz ◽  
A. C. Foster
Keyword(s):  
Rat Brain ◽  
Quinolinic Acid ◽  
Acid Metabolism

Increased quinolinic acid metabolism following neuronal degeneration in the rat hippocampus

1987 ◽  
Vol 436 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Carmela Speciale ◽  
Etsuo Okuno ◽  
Robert Schwarcz
Keyword(s):  
Quinolinic Acid ◽  
Acid Metabolism ◽  
Neuronal Degeneration ◽  
Rat Hippocampus

Effect of systemic kainate administration on cerebral quinolinic acid metabolism in the rat

1988 ◽  
Vol 99 (1) ◽  
pp. 213-218 ◽  
Author(s):  
Carmela Speciale ◽  
Robert Schwarcz
Keyword(s):  
Quinolinic Acid ◽  
Acid Metabolism

scholarly journals QUINOLINIC ACID METABOLISM

1949 ◽  
Vol 181 (2) ◽  
pp. 687-692
Author(s):  
L.M. Henderson ◽  
G.B. Ramasarma
Keyword(s):  
Quinolinic Acid ◽  
Acid Metabolism

scholarly journals QUINOLINIC ACID METABOLISM

1949 ◽  
Vol 181 (2) ◽  
pp. 677-685 ◽  
Author(s):  
L.M. Henderson
Keyword(s):  
Quinolinic Acid ◽  
Acid Metabolism

scholarly journals QUINOLINIC ACID METABOLISM

1949 ◽  
Vol 181 (2) ◽  
pp. 731-738 ◽  
Author(s):  
L.M. Henderson ◽  
G.B. Ramasarma ◽  
B. Connor Johnson
Keyword(s):  
Quinolinic Acid ◽  
Acid Metabolism

scholarly journals QUINOLINIC ACID METABOLISM

1949 ◽  
Vol 181 (2) ◽  
pp. 667-675 ◽  
Author(s):  
L.M. Henderson ◽  
Herbert M. Hirsch
Keyword(s):  
Quinolinic Acid ◽  
Acid Metabolism

Basal ganglia lesions in the rat: effects on quinolinic acid metabolism

1989 ◽  
Vol 490 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Robert Schwarcz ◽  
Etsuo Okuno ◽  
Robert J. White
Keyword(s):  
Basal Ganglia ◽  
Quinolinic Acid ◽  
Acid Metabolism

scholarly journals Allosteric Regulation of Bacillus subtilis NAD Kinase by Quinolinic Acid

2003 ◽  
Vol 185 (16) ◽  
pp. 4844-4850 ◽  
Author(s):  
Silvia Garavaglia ◽  
Alessandro Galizzi ◽  
Menico Rizzi
Keyword(s):  
Bacillus Subtilis ◽  
Quinolinic Acid ◽  
Acid Metabolism ◽  
Nad Kinase ◽  
Inorganic Polyphosphate ◽  
Nucleoside Triphosphates ◽  
Key Enzyme ◽  
Living Organisms ◽  
Allosteric Activator ◽  
Kinase Subfamily

ABSTRACT NADP is essential for biosynthetic pathways, energy, and signal transduction. In living organisms, NADP biosynthesis proceeds through the phosphorylation of NAD with a reaction catalyzed by NAD kinase. We expressed, purified, and characterized Bacillus subtilis NAD kinase. This enzyme represents a new member of the inorganic polyphosphate [poly(P)]/ATP NAD kinase subfamily, as it can use poly(P), ATP, or other nucleoside triphosphates as phosphoryl donors. NAD kinase showed marked positive cooperativity for the substrates ATP and poly(P) and was inhibited by its product, NADP, suggesting that the enzyme plays a major regulatory role in NADP biosynthesis. We discovered that quinolinic acid, a central metabolite in NAD(P) biosynthesis, behaved like a strong allosteric activator for the enzyme. Therefore, we propose that NAD kinase is a key enzyme for both NADP metabolism and quinolinic acid metabolism.

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