Factors involved in capillary growth in the heart

1995 ◽  
pp. 57-68
Author(s):  
Olga Hudlická ◽  
Margaret D. Brown ◽  
Helene Walter† ◽  
Jacqueline B. Weiss ◽  
Anita Bate
Keyword(s):  
Capillary Growth

scholarly journals Impaired myocardial capillarogenesis and increased adaptive capillary growth in FGF2-deficient mice

2005 ◽  
Vol 86 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Kerstin Amann ◽  
Jörg Faulhaber ◽  
Valentina Campean ◽  
Vitali Balajew ◽  
Rosanna Dono ◽  
...  
Keyword(s):  
Capillary Growth ◽  
Deficient Mice

Angiogenesis in the Heart and Skeletal Muscle — Models for Capillary Growth

Angiogenesis ◽  
1998 ◽  
pp. 19-33 ◽  
Author(s):  
O. Hudlicka ◽  
S. Egginton ◽  
M. D. Brown
Keyword(s):  
Skeletal Muscle ◽  
Capillary Growth ◽  
Muscle Models

Capillary growth in relation to blood flow and performance in overloaded rat skeletal muscle

1998 ◽  
Vol 85 (6) ◽  
pp. 2025-2032 ◽  
Author(s):  
S. Egginton ◽  
O. Hudlická ◽  
M. D. Brown ◽  
H. Walter ◽  
J. B. Weiss ◽  
...  
Keyword(s):  
Blood Flow ◽  
Muscle Blood Flow ◽  
Tibialis Anterior Muscle ◽  
Mechanical Stimulus ◽  
Angiogenic Factor ◽  
Protein Distribution ◽  
Blood Flows ◽  
Capillary Growth ◽  
Capillary Bed ◽  
And Performance

Rat extensor digitorum longus muscles were overloaded by stretch after removal of the synergist tibialis anterior muscle to determine the relationship between capillary growth, muscle blood flow, and presence of growth factors. After 2 wk, sarcomere length increased from 2.4 to 2.9 μm. Capillary-to-fiber ratio, estimated from alkaline phosphatase-stained frozen sections, was increased by 33% ( P < 0.0001) and 60% ( P < 0.01), compared with control muscles (1.44 ± 0.06) after 2 and 8 wk, respectively. At 2 wk, the increased capillary-to-fiber ratio was not associated with any changes in mRNA for basic fibroblast growth factor (FGF-2) or its protein distribution. FGF-2 immunoreactivity was present in nerves and large blood vessels but was negative in capillaries, whereas the activity of low-molecular endothelial-cell-stimulating angiogenic factor (ESAF) was 50% higher in stretched muscles. Muscle blood flows measured by radiolabeled microspheres during contractions were not significantly different after 2 or 8 wk (132 ± 37 and 177 ± 22 ml ⋅ min−1 ⋅ 100 g−1, respectively) from weight-matched controls (156 ± 12 and 150 ± 10 ml ⋅ min−1 ⋅ 100 g−1, respectively). Resistance to fatigue during 5-min isometric contractions (final/peak tension × 100) was similar in 2-wk overloaded and contralateral muscles (85 vs. 80%) and enhanced after 8 wk to 92%, compared with 77% in contralateral muscles and 67% in controls. We conclude that increased blood flow cannot be responsible for initiating expansion of the capillary bed, nor does it explain the reduced fatigue within overloaded muscles. However, stretch can present a mechanical stimulus to capillary growth, acting either directly on the capillary abluminal surface or by upregulating ESAF, but not FGF-2, in the extracellular matrix.

Angiogenesis in Skletal Muscle

Physiology ◽  
1986 ◽  
Vol 1 (5) ◽  
pp. 160-163
Author(s):  
HW Burton ◽  
JA Faulkner
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Blood Flow ◽  
Vasoactive Agents ◽  
Adult Skeletal Muscle ◽  
Capillary Growth ◽  
Vascular Bed ◽  
Chronic Electrical Stimulation ◽  
Capillary Bed ◽  
Ischemic Muscle

Capillary growth is rarely observed in normal adult skeletal muscle, but angiogenesis may occur after injury to a capillary bed or after endurance training or chronic electrical stimulation. Revascularization of ischemic muscle may arise as inward growth from surrounding vascularized tissue, as outward growth from endothelial cells in ischemic muscle, or a combination of the two processes. A regenerated vascular bed shows diminished response to vasoactive agents and impaired regulation of blood flow during contractions.

scholarly journals Capillary growth and regression in skeletal muscle

2014 ◽  
Vol 3 (5) ◽  
pp. 483-491 ◽  
Author(s):  
Hidemi Fujino ◽  
Hiroyo Kondo ◽  
Fumiko Nagatomo ◽  
Akihiko Ishihara
Keyword(s):  
Skeletal Muscle ◽  
Capillary Growth

Femtosecond laser ablation of chalcogenide glass: explosive formation of nano-fibres against thermo-capillary growth of micro-spheres

2006 ◽  
Vol 17 (19) ◽  
pp. 4802-4805 ◽  
Author(s):  
Saulius Juodkazis ◽  
Hiroaki Misawa ◽  
Oleg A Louchev ◽  
Kenji Kitamura
Keyword(s):  
Laser Ablation ◽  
Femtosecond Laser ◽  
Chalcogenide Glass ◽  
Femtosecond Laser Ablation ◽  
Capillary Growth
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