Role of Na+-K+-ATPase Activity in Regulation of Detrusor Contractility and Diabetic Bladder Dysfunction

1999 ◽  
pp. 293-302 ◽  
Author(s):  
Sandeep Gupta ◽  
Alan J. Wein
Keyword(s):  
Atpase Activity ◽  
Bladder Dysfunction ◽  
Detrusor Contractility ◽  
Diabetic Bladder

Changed Responsiveness of the Detrusor in Rabbits With Alloxan Induced Hyperglycemia: Possible Role of 5-Hydroxytryptamine for Diabetic Bladder Dysfunction

2002 ◽  
pp. 303-307 ◽  
Author(s):  
NOBUTAKA ICHIYANAGI ◽  
TOSHIHIKO TSUJII ◽  
HITOSHI MASUDA ◽  
KAZUNORI KIHARA ◽  
MORITAKA GOTO ◽  
...  
Keyword(s):  
Bladder Dysfunction ◽  
Diabetic Bladder

scholarly journals Detrusor contractility to parasympathetic mediators is differentially altered in the compensated and decompensated states of diabetic bladder dysfunction

2019 ◽  
Vol 317 (2) ◽  
pp. F388-F398 ◽  
Author(s):  
Nicole S. Klee ◽  
Robert S. Moreland ◽  
Derek M. Kendig
Keyword(s):  
Bladder Dysfunction ◽  
Receptor Expression ◽  
Detrusor Muscle ◽  
Underactive Bladder ◽  
Detrusor Contractility ◽  
Patients With Diabetes ◽  
Exogenous Addition ◽  
Bladder Symptoms ◽  
Diabetic Bladder

Diabetic bladder dysfunction (DBD) affects up to 50% of all patients with diabetes, characterized by symptoms of both overactive and underactive bladder. Although most diabetic bladder dysfunction studies have been performed using models with type 1 diabetes, few have been performed in models of type 2 diabetes, which accounts for ~90% of all diabetic cases. In a type 2 rat model using a high-fat diet (HFD) and two low doses of streptozotocin (STZ), we examined voiding measurements and functional experiments in urothelium-denuded bladder strips to establish a timeline of disease progression. We hypothesized that overactive bladder symptoms (compensated state) would develop and progress into symptoms characterized by underactive bladder (decompensated state). Our results indicated that this model developed the compensated state at 1 wk after STZ and the decompensated state at 4 mo after STZ administration. Diabetic bladders were hypertrophied compared with control bladders. Increased volume per void and detrusor muscle contractility to exogenous addition of carbachol and ATP confirmed the development of the compensated state. This enhanced contractility to carbachol was not due to increased levels of M3 receptor expression. Decompensation was characterized by increased volume per void, number of voids, and contractility to ATP but not carbachol. Thus, progression from the compensated to decompensated state may involve decreased contractility to muscarinic stimulation. These data suggest that the compensated state of DBD progresses temporally into the decompensated state in the male HFD/STZ model of diabetes; therefore, this male HFD/STZ model can be used to study the progression of DBD.

Changed Responsiveness of the Detrusor in Rabbits With Alloxan Induced Hyperglycemia: Possible Role of 5-Hydroxytryptamine for Diabetic Bladder Dysfunction

2002 ◽  
Vol 168 (1) ◽  
pp. 303-307 ◽  
Author(s):  
Nobutaka Ichiyanagi ◽  
Toshihiko Tsujii ◽  
Hitoshi Masuda ◽  
Kazunori Kihara ◽  
Moritaka Goto ◽  
...  
Keyword(s):  
Bladder Dysfunction ◽  
Diabetic Bladder

Role of skeletal muscle Na+–K+ ATPase activity in increased lactate production in sub–acute sepsis

Life Sciences ◽  
2002 ◽  
Vol 70 (16) ◽  
pp. 1875-1888 ◽  
Author(s):  
Freda D McCarter ◽  
S.Renee Nierman ◽  
J.Howard James ◽  
Li Wang ◽  
Jy-Kung King ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Atpase Activity ◽  
Lactate Production
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