Multisubunit Allosteric Proteins

1998 ◽  
pp. 27-35 ◽  
Author(s):  
William N. Lipscomb
Keyword(s):  
Allosteric Proteins

New structures of allosteric proteins revealing remarkable conformational changes

1996 ◽  
Vol 6 (6) ◽  
pp. 824-829 ◽  
Author(s):  
Andrea Mattevi ◽  
Menico Rizzi ◽  
Martino Bolognesi
Keyword(s):  
Conformational Changes ◽  
Allosteric Proteins

scholarly journals Direct analysis of cooperativity in multisubunit allosteric proteins

2008 ◽  
Vol 105 (33) ◽  
pp. 11697-11702 ◽  
Author(s):  
N. Zandany ◽  
M. Ovadia ◽  
I. Orr ◽  
O. Yifrach
Keyword(s):  
Direct Analysis ◽  
Allosteric Proteins

scholarly journals Allosteric proteins as logarithmic sensors

2016 ◽  
Vol 113 (30) ◽  
pp. E4423-E4430 ◽  
Author(s):  
Noah Olsman ◽  
Lea Goentoro
Keyword(s):  
Signal Transduction ◽  
Molecular Level ◽  
Fold Change ◽  
Logarithmic Scale ◽  
Biological Processes ◽  
Present Evidence ◽  
Allosteric Proteins ◽  
Single Protein ◽  
The Many ◽  
Fold Change Detection

Many sensory systems, from vision and hearing in animals to signal transduction in cells, respond to fold changes in signal relative to background. Responding to fold change requires that the system senses signal on a logarithmic scale, responding identically to a change in signal level from 1 to 3, or from 10 to 30. It is an ongoing search in the field to understand the ways in which a logarithmic sensor can be implemented at the molecular level. In this work, we present evidence that logarithmic sensing can be implemented with a single protein, by means of allosteric regulation. Specifically, we find that mathematical models show that allosteric proteins can respond to stimuli on a logarithmic scale. Next, we present evidence from measurements in the literature that some allosteric proteins do operate in a parameter regime that permits logarithmic sensing. Finally, we present examples suggesting that allosteric proteins are indeed used in this capacity: allosteric proteins play a prominent role in systems where fold-change detection has been proposed. This finding suggests a role as logarithmic sensors for the many allosteric proteins across diverse biological processes.

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