Hard tissue response

Author(s):  
T. Albrektsson
Keyword(s):  
Author(s):  
V. Jasty ◽  
M. Jarcho ◽  
K. I. Gumaer ◽  
R. Sauerschell ◽  
H. P. Drobeck

Ceramics have distinct advantages over many other materials for use as implantable prosthetic devices. As implant materials, they are virtually nonreactive, and unlike many metals they are corrosion resistant. When properly formulated and fabricated, their compressive and tensile strengths would be appropriate for use as prosthetic devices. A new process for preparing a dense polycrystalline hydroxylapatite (HA) ceramic called durapatite has been formulated. This material appears particularly attractive as a candidate for hard tissue implant because of its strength and because its chemical composition closely resembles that of vertebrate bone and tooth minerals.Durapatite in the form of dense plugs was surgically implanted into drilled holes in the femurs of four adult mongrel dogs. Two dogs were sacrificed two months postimplantation and two at approximately seven months.


2013 ◽  
Vol 17 (3) ◽  
pp. 483-496 ◽  
Author(s):  
Allauddin Siddiqi ◽  
Jules August Kieser ◽  
Rohana Kumara De Silva ◽  
William Murray Thomson ◽  
Warwick John Duncan

2001 ◽  
Vol 59 (3) ◽  
pp. 547-556 ◽  
Author(s):  
John P. Fisher ◽  
Johan W. M. Vehof ◽  
David Dean ◽  
Jan Paul C. M. van der Waerden ◽  
Theresa A. Holland ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Travis K. Mann-Gow ◽  
Benjamin J. King ◽  
Ahmed El-Ghannam ◽  
Christine Knabe-Ducheyne ◽  
Masatoshi Kida ◽  
...  

Objectives. To test the physical properties and host response to the bioceramic particles, silica-calcium phosphate (SCPC10) and Cristobalite, in a rat animal model and compare their biocompatibility to the current clinically utilized urethral bulking materials.Material and Methods. The novel bulking materials, SCPC10 and Cristobalite, were suspended in hyaluronic acid sodium salt and injected into the mid urethra of a rat. Additional animals were injected with bulking materials currently in clinical use. Physiological response was assessed using voiding trials, and host tissue response was evaluated using hard tissue histology and immunohistochemical analysis. Distant organs were evaluated for the presence of particles or their components.Results. Histological analysis of the urethral tissue five months after injection showed that both SCPC10 and Cristobalite induced a more robust fibroblastic and histiocytic reaction, promoting integration and encapsulation of the particle aggregates, leading to a larger bulking effect. Concentrations of Ca, Na, Si, and P ions in the experimental groups were comparable to control animals.Conclusions. This side-by-side examination of urethral bulking agents using a rat animal model and hard tissue histology techniques compared two newly developed bioactive ceramic particles to three of the currently used bulking agents. The local host tissue response and bulking effects of bioceramic particles were superior while also possessing a comparable safety profile.


2012 ◽  
Vol 83 (3) ◽  
pp. 533-539 ◽  
Author(s):  
Gundega Jakobsone ◽  
Arild Stenvik ◽  
Lisen Espeland

ABSTRACT Objective: To analyze the impact of surgical change in anterior face height and skeletal relapse on the long-term soft tissue profile. Materials and Methods: Cephalometric radiographs of 81 patients taken before surgery and at five time points during a 3-year follow-up period were analyzed. All patients had Le Fort I and bilateral sagittal split osteotomies. The patients were divided into three subgroups according to the change in anterior face height during surgery. Calculations of soft to hard tissue ratios were based on the long-term soft tissue response relative to the surgical repositioning. Results: The horizontal surgical repositioning varied considerably, depending on whether anterior face height was increased or decreased. For upper lip prominence, the pattern of long-term change was the same irrespective of change in face height. In all groups, upper lip thickness decreased in both the short term and the long term, particularly in patients with surgical increase in face height. Lower lip thickness increased in the short term but decreased during the follow-up period. There were significant associations between horizontal soft tissue and corresponding hard tissue changes, except for soft tissue A-point and upper lip, when face height was increased. The ratios were higher for mandibular variables than for maxillary variables, particularly for B-point and pogonion when anterior face height had decreased. Conclusion: A change in facial height influences the soft tissue response. The mandibular soft tissues closely follow skeletal relapse beyond 2 months postsurgery. The findings have clinical implications for the relative maxillary and mandibular repositioning when planning surgery.


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