The Presynaptic Component of a Cholinergic Mechanism in the Carotid Body Chemotransduction of Hypoxia in the Cat

1996 ◽  
pp. 245-252 ◽  
Author(s):  
Robert S. Fitzgerald ◽  
Machiko Shirahata ◽  
Yumiko Ishizawa
Keyword(s):  
Carotid Body ◽  
Cholinergic Mechanism

Presynaptic neurotransmitter and chemosensory responses to natural stimuli

1984 ◽  
Vol 56 (2) ◽  
pp. 447-453 ◽  
Author(s):  
M. Pokorski ◽  
S. Lahiri
Keyword(s):  
Carotid Body ◽  
Nerve Terminals ◽  
Cholinergic Mechanism ◽  
Natural Stimuli ◽  
Release Of Acetylcholine ◽  
Ventilatory Effects ◽  
Presynaptic Nerve Terminals ◽  
Carotid Body Chemoreceptors ◽  
Arterial Po2 ◽  
Stimulation Of

We investigated the hypothesis that release of acetylcholine from presynaptic nerve terminals in the carotid body may be responsible for the excitation of carotid body chemoreceptors by hypoxia and hypercapnia and central ventilatory stimulation by hypercapnia. 4-Aminopyridine, an agent known to release presynaptic transmitters including acetylcholine, was administered intravenously (1 mg X kg-1) or by close intra-arterial injection to the carotid body (200 micrograms) in anesthetized cats. 4-Aminopyridine did not change the carotid chemosensory responses to any arterial PO2 or PCO2 levels studied, whereas it stimulated ventilation at all arterial PO2 and PCO2 levels. Atropine blocked the ventilatory effects of 4-aminopyridine but not the responses to hypoxia and hypercapnia. The results add to the evidence, which shows that the presynaptic cholinergic mechanism is not germane to carotid body chemoreception. Also, acetylcholine does not seem to mediate the central hypercapnic stimulation of ventilation.

Fine Structure of Carotid Body: Normal and Anoxic Cats

1967 ◽  
Vol 25 ◽  
pp. 150-151
Author(s):  
Fadhil Al-Lami ◽  
R.G. Murray
Keyword(s):  
Fine Structure ◽  
Adrenal Medulla ◽  
Carotid Body ◽  
Uranyl Acetate ◽  
Lead Citrate ◽  
Glomus Cells ◽  
Sustentacular Cells ◽  
Carotid Bodies

Although the fine structure of the carotid body has been described in several recent reports, uncertainties remain, and the morphological effects of anoxia on the carotid body cells of the cat have never been reported. We have, therefore, studied the fine structure of the carotid body both in normal and severely anoxic cats, and to test the specificity of the effects, have compared them with the effects on adrenal medulla, kidney, and liver of the same animals. Carotid bodies of 50 normal and 15 severely anoxic cats (9% oxygen in nitrogen) were studied. Glutaraldehyde followed by OsO4 fixations, Epon 812 embedding, and uranyl acetate and lead citrate staining, were the technics employed.We have called the two types of glomus cells enclosed and enclosing cells. They correspond to those previously designated as chemoreceptor and sustentacular cells respectively (1). The enclosed cells forming the vast majority, are irregular in shape with many processes and occasional peripheral densities (Fig. 1).

Onyx Embolization of Carotid Body Paragangliomas: An Adjunct to Safe and Effective Surgical Resection

2013 ◽  
Vol 74 (S 01) ◽  
Author(s):  
Felipe Albuquerque ◽  
Cameron McDougall ◽  
Robert Spetzler ◽  
Andrew Ducruet ◽  
Webster Crowley ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Carotid Body

Bilateral Glomus Jugularae Paragangliomas Treated with Fractionated Stereotactic Intensity-Modulated Radiotherapy in a Patient with Past History of Bilateral Carotid Body Tumors

Skull Base ◽  
2007 ◽  
Vol 17 (S 2) ◽  
Author(s):  
Edward Melian ◽  
John Leonetti ◽  
Elke Aippersbach ◽  
Anil Sethi ◽  
Douglas Anderson ◽  
...  
Keyword(s):  
Carotid Body ◽  
Past History ◽  
Intensity Modulated Radiotherapy ◽  
Intensity Modulated ◽  
Bilateral Carotid ◽  
History Of ◽  
Carotid Body Tumors

Presentation with Personality changes and Tinnitus to a Vascular Intervention: Rare case of Carotid Body Paraganglioma

2018 ◽  
pp. e000109
Author(s):  
Ahsan Zil-E-Ali ◽  
Zubair Ahmed ◽  
Amber Ehsan Faquih ◽  
Muhammad Ishaq ◽  
Muhammad Aadil
Keyword(s):  
Case Report ◽  
Carotid Body ◽  
Neuroendocrine Neoplasms ◽  
Vascular Surgeon ◽  
Vascular Intervention ◽  
Presenting Symptoms ◽  
Personality Changes ◽  
Tender Mass ◽  
Carotid Body Tumors ◽  
General Physical

Background: Carotid body paragangliomas are rare neuroendocrine neoplasms of chromaffin negative glomus cells. This case report explains an atypical case with unusual presentation and treatment. Case Report: A healthy smoker technician by profession was brought to the emergency room (ER) with coprolalia. The general physical exam did not reveal any information. His history revealed unilateral tinnitus and odynophagia leading to a consultation by the neurologist with head imaging. Acoustic neuroma was ruled out and the caregiver was asked to elaborate the events mentioned in the history and a psychiatric examination was done. The personality changes were evaluated by the psychiatrist that showed overlapping of delirium and depression. The patient was further examined by a vascular surgeon. After careful revisiting of the history, examination and indication of tender mass in the neck by the patient's vascular surgeon, the diagnosis of carotid body paraganglioma was made which was followed by surgical resection for treatment. Conclusion: Carotid Body Paragangliomas are very vascular structures and their manipulation in a surgery setting requires expertise. This case presented with personality changes and tinnitus, a very less likely event to occur in a carotid body tumor. The present care report, thus adds on to the literature of carotid body tumors and its presenting symptoms.

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