Mammalian Cell Proliferation is Regulated by the Synergistic Actions of Multiple Growth Factors

1982 ◽  
pp. 287-300
Author(s):  
W. J. Pledger ◽  
C. A. Hart ◽  
W. R. Wharton
Keyword(s):  
Cell Proliferation ◽  
Growth Factors ◽  
Mammalian Cell

Bacterially produced inclusion bodies as biocompatible materials for substrate-dependent mammalian cell proliferation

2010 ◽  
Vol 150 ◽  
pp. 434-435
Author(s):  
J. Seras ◽  
C. Díez-Gil ◽  
E. Vazquez ◽  
S. Krabbenborg ◽  
E. Rodríguez-Carmona ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mammalian Cell ◽  
Inclusion Bodies ◽  
Biocompatible Materials

Beta cell proliferation and growth factors

1999 ◽  
Vol 77 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Jens Høiriis Nielsen ◽  
C. Svensson ◽  
Elisabeth Douglas Galsgaard ◽  
Annette Møldrup ◽  
Nils Billestrup
Keyword(s):  
Cell Proliferation ◽  
Growth Factors ◽  
Beta Cell ◽  
Beta Cell Proliferation

Role of Growth Factors in the Control of Leukemic Cell Proliferation

1994 ◽  
Vol 13 (sup1) ◽  
pp. 35-37 ◽  
Author(s):  
Christian Chabannon ◽  
Patrice Mannoni
Keyword(s):  
Cell Proliferation ◽  
Growth Factors ◽  
Leukemic Cell

Role of Intracellular pH in Mammalian Cell Proliferation

1992 ◽  
Vol 2 (3-4) ◽  
pp. 159-179 ◽  
Author(s):  
R.J. Gillies ◽  
R. Martinez-Zaguilan ◽  
E.P. Peterson ◽  
R. Perona
Keyword(s):  
Cell Proliferation ◽  
Intracellular Ph ◽  
Mammalian Cell

scholarly journals Long-range memory of growth and cycle progression correlates cell cycles in lineage trees

2018 ◽  
Author(s):  
Erika E Kuchen ◽  
Nils Becker ◽  
Nina Claudino ◽  
Thomas Höfer
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Growth ◽  
Mammalian Cell ◽  
Latent Variable ◽  
Cycle Length ◽  
Growth Control ◽  
Minimum Size ◽  
Cell Cycles ◽  
Lineage Trees

Mammalian cell proliferation is controlled by mitogens. However, how proliferation is coordinated with cell growth is poorly understood. Here we show that statistical properties of cell lineage trees – the cell-cycle length correlations within and across generations – reveal how cell growth controls proliferation. Analyzing extended lineage trees with latent-variable models, we find that two antagonistic heritable variables account for the observed cycle-length correlations. Using molecular perturbations of mTOR and MYC we identify these variables as cell size and regulatory license to divide, which are coupled through a minimum-size checkpoint. The checkpoint is relevant only for fast cell cycles, explaining why growth control of mammalian cell proliferation has remained elusive. Thus, correlated fluctuations of the cell cycle encode its regulation.

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