Methodology for Study of Isolated Perfused Dog Kidney in Situ

1978 ◽  
pp. 351-367 ◽  
Author(s):  
George J. Kaloyanides
Keyword(s):  
Dog Kidney

Release of PGE and PGI2 in the pump-perfused dog kidney and associated hypotension

1981 ◽  
Vol 240 (6) ◽  
pp. F545-F550
Author(s):  
P. C. Wong ◽  
B. G. Zimmerman ◽  
P. Friedman
Keyword(s):  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Control Group ◽  
Angiotensin System ◽  
Arterial Blood ◽  
Dog Kidney ◽  
Anesthetized Dogs ◽  
Treatment Changes ◽  
Pg Release

The mechanism of enhanced renal prostaglandin (PG) release in the in situ pump-perfused kidney was studied in anesthetized dogs. Pump perfusion caused a gradual decrease in mean arterial blood pressure (BP) from 163 to 128 mmHg over an 80-min period. The renal arteriovenous level of PGE and plasma renin activity (PRA) were increased by a mean of 1.36 ng/ml and 22 ng AI.ml-1.h-1, respectively. In a second group of dogs treated with captopril, pump perfusion did not alter PGE or BP, but increased PRA. When the animals were treated with indomethacin, the renal arteriovenous levels of PGE and 6-keto-PGF1 alpha were not changed but PRA increased during the 80 min of pump perfusion. In a fourth group of dogs that had undergone renal denervation and phentolamine treatment, changes in PGE and BP occurred during pump perfusion similar to the changes in the control group, and 6-keto-PGF1 alpha release by the kidney also increased. The results indicate that renal PG release during group perfusion is mainly due to the activation of the renin-angiotensin system and that the hypotension due to pump perfusion is PG mediated.

Deep Venous and Lymphatic Vessel Pressures During Renal Autoregulation in the in situ Dog Kidney

1969 ◽  
Vol 131 (2) ◽  
pp. 642-645 ◽  
Author(s):  
S. Gazitua ◽  
J. B. Scott ◽  
T. E. Emerson ◽  
F. J. Haddy
Keyword(s):  
Lymphatic Vessel ◽  
Renal Autoregulation ◽  
Dog Kidney

Pressure induced changes of renal flow resistance in the dog kidney in situ

1971 ◽  
Vol 325 (2) ◽  
pp. 95-102 ◽  
Author(s):  
K. Held ◽  
W. Niedermayer ◽  
J. Schaefer ◽  
H. J. Schwarzkopf ◽  
Ch. Weiss
Keyword(s):  
Flow Resistance ◽  
Dog Kidney ◽  
Renal Flow ◽  
Induced Changes

Trapping of urea by red cells in the kidney

1965 ◽  
Vol 209 (2) ◽  
pp. 253-263 ◽  
Author(s):  
Francis P. Chinard ◽  
Carl A. Goresky ◽  
Theodore Enns ◽  
Mary F. Nolan ◽  
R. Winifred House
Keyword(s):  
Carrier Transport ◽  
Red Cells ◽  
Equilibration Time ◽  
Similar System ◽  
Multiple Indicator Dilution ◽  
Transit Times ◽  
Dog Kidney ◽  
Multiple Indicator

Outflow patterns of T-1824, urea, thiourea, and creatinine have been determined in the dog kidney in vivo and in situ as a function of the arterial hematocrit by means of the multiple indicator-dilution technique. The mean transit times of T-1824, urea, and creatinine decrease and converge as the hematocrit decreases. The outflow patterns of urea are anomalous: a) there is precession of urea over creatinine and thiourea; b) the transit times of urea are shorter than those of creatinine and thiourea; c) the recoveries of urea are greater than those of creatinine at normal and high hematocrit values. Thiourea has a longer equilibration time with red cells than urea. Prior incubation of thiourea with red cells results in precession of thiourea over urea. These results are considered evidence of transient trapping of urea in red cells during their passage through the glomerular capillaries. The similarity of the urea outflow curves to curves of substances known to participate in a membrane carrier transport system by the tubule cells from the antiluminal side suggest that urea may participate in a similar system.

Physiology of pump-perfused in situ dog kidney

1969 ◽  
Vol 217 (6) ◽  
pp. 1809-1813 ◽  
Author(s):  
GL Wolf ◽  
RG Dluhy ◽  
DP Lauler
Keyword(s):  
Dog Kidney

Rendez vous with Saturn's rings

1984 ◽  
Vol 75 ◽  
pp. 743-759 ◽  
Author(s):  
Kerry T. Nock
Keyword(s):  
Solar Energy ◽  
Electric Propulsion ◽  
Power Source ◽  
Propulsion System ◽  
Low Thrust ◽  
Ring Plane ◽  
The Earth ◽  
Total Impulse ◽  
Saturn's Rings

ABSTRACTA mission to rendezvous with the rings of Saturn is studied with regard to science rationale and instrumentation and engineering feasibility and design. Future detailedin situexploration of the rings of Saturn will require spacecraft systems with enormous propulsive capability. NASA is currently studying the critical technologies for just such a system, called Nuclear Electric Propulsion (NEP). Electric propulsion is the only technology which can effectively provide the required total impulse for this demanding mission. Furthermore, the power source must be nuclear because the solar energy reaching Saturn is only 1% of that at the Earth. An important aspect of this mission is the ability of the low thrust propulsion system to continuously boost the spacecraft above the ring plane as it spirals in toward Saturn, thus enabling scientific measurements of ring particles from only a few kilometers.

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