Effects of Leukotrienes C4 and D4, Cyclic AMP and Methylation Reactions on Arachidonic Acid Metabolism in Rat Peritoneal Macrophages

1983 ◽  
pp. 135-146
Author(s):  
N. Feuerstein ◽  
P. W. Ramwell
Keyword(s):  
Arachidonic Acid ◽  
Cyclic Amp ◽  
Acid Metabolism ◽  
Peritoneal Macrophages ◽  
Arachidonic Acid Metabolism

Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages

1988 ◽  
Vol 971 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Kazuo Ohuchi ◽  
Masako Watanabe ◽  
Noriyasu Hirasawa ◽  
Susumu Tsurufuji ◽  
Tsuneo Ozeki ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Peritoneal Macrophages ◽  
Arachidonic Acid Metabolism ◽  
Tumor Promoter

scholarly journals Cholera toxin induces expression of the immediate-early response gene JE via a cyclic AMP-independent signaling pathway.

1991 ◽  
Vol 11 (1) ◽  
pp. 102-107 ◽  
Author(s):  
S A Qureshi ◽  
K Alexandropoulos ◽  
C K Joseph ◽  
R Spangler ◽  
D A Foster
Keyword(s):  
Gene Expression ◽  
Arachidonic Acid ◽  
Protein Kinase ◽  
Cyclic Amp ◽  
Cholera Toxin ◽  
Signaling Pathway ◽  
Acid Metabolism ◽  
Early Response ◽  
Arachidonic Acid Metabolism ◽  
Immediate Early

Cholera toxin (CT) activates expression of two immediate-early response genes (JE and TIS10) in quiescent BALB/c 3T3 cells. Increases in cyclic AMP (cAMP) levels in response to CT are likely responsible for the induction of TIS10 gene expression, since treatment with 8-Br-cAMP and increasing the intracellular levels of cAMP by treatment with forskolin induce TIS10 gene expression. In contrast, neither forskolin nor 8-Br-cAMP induces JE gene expression. 3-Isobutyl-1-methylxanthine, which stabilizes intracellular cAMP, potentiates CT-induced TIS10 gene expression but has no effect on CT-induced JE gene expression. Thus, induction of JE by CT is independent of the cAMP produced in response to CT. Induction of JE by CT does not require protein kinase C (PKC), since depleting cells of PKC activity has no effect on the induction of JE by CT. CT-induced expression of JE can be distinguished from CT-induced TIS10 gene expression by using protein kinase inhibitors and inhibitors of arachidonic acid metabolism, further suggesting distinct signaling pathways for CT-induced JE and TIS10 gene expression. Thus, induction of JE gene expression by CT results from the activation of an intracellular signaling pathway that is independent of cAMP production. This pathway is independent of PKC activity and uniquely sensitive to inhibitors of protein kinases and arachidonic acid metabolism.

Influence of a Cytomegalovirus Infection on Functions and Arachidonic Acid Metabolism of Rat Peritoneal Macrophages

1989 ◽  
Vol 45 (5) ◽  
pp. 466-473 ◽  
Author(s):  
Wim Engels ◽  
Gert Grauls ◽  
Paul J. Lemmens ◽  
Wil J. Mullers ◽  
Cathrien A. Bruggeman
Keyword(s):  
Arachidonic Acid ◽  
Cytomegalovirus Infection ◽  
Acid Metabolism ◽  
Peritoneal Macrophages ◽  
Arachidonic Acid Metabolism

Dual effects of staurosporine on arachidonic acid metabolism in rat peritoneal macrophages

1990 ◽  
Vol 1047 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Masako Watanabe ◽  
Toshiya Tamura ◽  
Mariko Ohashi ◽  
Noriyasu Hirasawa ◽  
Tsuneo Ozeki ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Peritoneal Macrophages ◽  
Arachidonic Acid Metabolism

scholarly journals Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages

1988 ◽  
Vol 94 (3) ◽  
pp. 917-923 ◽  
Author(s):  
Kazuo Ohuchi ◽  
Tadaki Sugawara ◽  
Masako Watanabe ◽  
Noriyasu Hirasawa ◽  
Susumu Tsurufuji ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Peritoneal Macrophages ◽  
Arachidonic Acid Metabolism
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