Gel Filtration of Concentrated Urine: the Relation Between Calcium Oxalate Crystal Growth Inhibition and Glycosaminoglycan Chromatograms

1985 ◽  
pp. 823-826 ◽  
Author(s):  
B. Fellström ◽  
B. G. Danielson ◽  
S. Ljunghall ◽  
B. Wikström
Keyword(s):  
Crystal Growth ◽  
Growth Inhibition ◽  
Calcium Oxalate ◽  
Gel Filtration ◽  
Calcium Oxalate Crystal ◽  
Crystal Growth Inhibition

Influence of Gender and Age on Calcium Oxalate Crystal Growth Inhibition by Urine from Relatives of Stone Forming Patients

2002 ◽  
pp. 2372-2376 ◽  
Author(s):  
KRISTIN J. BERGSLAND ◽  
JENNIFER M. KINDER ◽  
JOHN R. ASPLIN ◽  
BRIAN J. COE ◽  
FREDRIC L. COE
Keyword(s):  
Crystal Growth ◽  
Growth Inhibition ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal ◽  
Gender And Age ◽  
Crystal Growth Inhibition

The effect of warfarin on urine calcium oxalate crystal growth inhibition and urinary excretion of calcium and nephrocalcin

1993 ◽  
Vol 53 (4) ◽  
pp. 242-248 ◽  
Author(s):  
Elaine M. Worcester ◽  
James L. Sebastian ◽  
Janet G. Hiatt ◽  
Ann M. Beshensky ◽  
James A. Sadowski
Keyword(s):  
Crystal Growth ◽  
Urinary Excretion ◽  
Growth Inhibition ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal ◽  
Urine Calcium ◽  
Crystal Growth Inhibition

The Contribution of the Bladder to Calcium Oxalate Crystal Growth Inhibition in Voided Urine

1985 ◽  
pp. 871-873 ◽  
Author(s):  
X. Martin ◽  
T. J. Opgenorth ◽  
P. G. Werness ◽  
R. T. Rundquist ◽  
J. C. Romero ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Growth Inhibition ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal ◽  
Crystal Growth Inhibition

Influence of Gender and Age on Calcium Oxalate Crystal Growth Inhibition by Urine from Relatives of Stone Forming Patients

2002 ◽  
Vol 167 (6) ◽  
pp. 2372-2376 ◽  
Author(s):  
KRISTIN J. BERGSLAND ◽  
JENNIFER M. KINDER ◽  
JOHN R. ASPLIN ◽  
BRIAN J. COE ◽  
FREDRIC L. COE
Keyword(s):  
Crystal Growth ◽  
Growth Inhibition ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal ◽  
Gender And Age ◽  
Crystal Growth Inhibition

Acidic peptide and polyribonucleotide crystal growth inhibitors in human urine

1977 ◽  
Vol 233 (5) ◽  
pp. F455-F463 ◽  
Author(s):  
H. Ito ◽  
F. L. Coe
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Gel Filtration ◽  
Subsequent Treatment ◽  
Calcium Oxalate Crystal ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Acidic Peptide ◽  
Gastric Pepsin

Urine contains nondialyzable inhibitors of calcium oxalate crystal growth. We have pursued the hypothesis that these inhibitors may, in part, be acidic peptides and polyribonucleotide fragments. Homopolyribonucleotides and RNA inhibit calcium oxalate crystal growth at 5 x 10(-6) M of constituent ribonucleotide, whereas the monomer nucleotides are inactive at 10(-4) M. Poly-L-aspartic or glutamic acid are also inhibitory at 5 X 10(-6) M of amino acid, whereas the monomeric amino acids are inert. Gastric pepsin, a naturally occurring acidic peptide, is inhibitory. Incubation with nonspecific protease reduced the inhibitory effectiveness of normal human urine consistently and significantly, a fact compatible with an important contribution of peptides. A variable additional reduction was produced by subsequent treatment with ribonuclease, suggesting only a small role for polyribonucleotide. Sequential ion exchange and gel filtration chromatography and preparative disc gel electrophoresis yielded inhibitory material enriched with peptides that were strongly acidic and high in proline. Peptides and ribonucleotides seem to contribute to urinary nondialyzable crystal growth inhibitory activity.

scholarly journals Normal calcium oxalate crystal growth inhibition in severe calcium oxalate nephrolithiasis.

1996 ◽  
Vol 7 (4) ◽  
pp. 602-607
Author(s):  
J L Porile ◽  
J R Asplin ◽  
J H Parks ◽  
Y Nakagawa ◽  
F L Coe
Keyword(s):  
Crystal Growth ◽  
Growth Inhibition ◽  
Calcium Oxalate ◽  
Matched Control ◽  
Solid Phase ◽  
Stone Formation ◽  
Stone Disease ◽  
Calcium Oxalate Crystal ◽  
Control Subjects ◽  
Age And Sex

Urine from mammalian kidneys is regularly supersaturated with respect to calcium oxalate monohydrate, the most common solid phase in human nephrolithiasis, and also inhibits the nucleation, growth, and aggregation of calcium oxalate crystals. Nephrolithiasis is often associated with increased supersaturation, and it is assumed that this increase overbalances the inhibition effects, causing stones. However, some patients form stones in the absence of increased supersaturation, and in those patients, one might assume that reduced inhibition is the cause of their stones. This hypothesis was tested in 25 patients who formed at least ten stones each, yet lacked the usual metabolic abnormalities that increase supersaturation. Compared with 25 age- and sex-matched control subjects, urine supersaturation among the patients was not increased; this is an expected result of this study's selection criteria. Compared with the same age- and sex-matched control subjects, urine from the patients showed no evidence for reduced inhibition of calcium oxalate crystal growth, so low inhibition of growth did not contribute to pathogenesis of stones in our highly selected study population, despite their otherwise unexplained and active stone formation. These results do not support the hypothesis that growth inhibition defects are a cause of stone disease.

Molecular Mechanism of Crystal Growth Inhibition at the Calcium Oxalate/Water Interfaces

2016 ◽  
Vol 120 (8) ◽  
pp. 4410-4417 ◽  
Author(s):  
Leila Salimi Parvaneh ◽  
Davide Donadio ◽  
Marialore Sulpizi
Keyword(s):  
Crystal Growth ◽  
Growth Inhibition ◽  
Calcium Oxalate ◽  
Molecular Mechanism ◽  
Crystal Growth Inhibition

scholarly journals IN VITRO STUDIES ON CALCIUM OXALATE CRYSTAL GROWTH INHIBITION OF STROBILANTHES CRISPUS EXTRACTS

2015 ◽  
Vol 3 (1) ◽  
pp. 8
Author(s):  
Afrizal Itam ◽  
Zhari Ismail ◽  
Amin Malik Shah Abdul Majid
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Sodium Citrate ◽  
Water Extract ◽  
Positive Control ◽  
Calcium Oxalate Crystal ◽  
Strobilanthes Crispus ◽  
Crystal Growth Inhibition ◽  
Acetone Extracts

 ABSTRACT Strobilanthes crispus L. (Acanthaceae) has been used locally in traditional medicine for kidney stone and related diseases. These plant extracts have the ability to inhibit the calcium oxalate crystal growth, where the ability of water extract is higher than those of the 70% acetone, methanol and acetone extracts. The ability to inhibit the calcium oxalate crystal growth of these extracts is lower than that of sodium citrate as positive control. Keywords: Strobilanthes crispus, Acanthaceae, crystal inhibition, calcium oxalate

Inhibition of Calcium Oxalate Crystal Growth in Patients with Urolithiasis

Urolithiasis ◽  
1981 ◽  
pp. 623-629 ◽  
Author(s):  
Hans-Göran Tiselius ◽  
Lasse Larsson
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal
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