The effect of warfarin on urine calcium oxalate crystal growth inhibition and urinary excretion of calcium and nephrocalcin

1993 ◽  
Vol 53 (4) ◽  
pp. 242-248 ◽  
Author(s):  
Elaine M. Worcester ◽  
James L. Sebastian ◽  
Janet G. Hiatt ◽  
Ann M. Beshensky ◽  
James A. Sadowski
Author(s):  
X. Martin ◽  
T. J. Opgenorth ◽  
P. G. Werness ◽  
R. T. Rundquist ◽  
J. C. Romero ◽  
...  

2002 ◽  
Vol 167 (6) ◽  
pp. 2372-2376 ◽  
Author(s):  
KRISTIN J. BERGSLAND ◽  
JENNIFER M. KINDER ◽  
JOHN R. ASPLIN ◽  
BRIAN J. COE ◽  
FREDRIC L. COE

1996 ◽  
Vol 7 (4) ◽  
pp. 602-607
Author(s):  
J L Porile ◽  
J R Asplin ◽  
J H Parks ◽  
Y Nakagawa ◽  
F L Coe

Urine from mammalian kidneys is regularly supersaturated with respect to calcium oxalate monohydrate, the most common solid phase in human nephrolithiasis, and also inhibits the nucleation, growth, and aggregation of calcium oxalate crystals. Nephrolithiasis is often associated with increased supersaturation, and it is assumed that this increase overbalances the inhibition effects, causing stones. However, some patients form stones in the absence of increased supersaturation, and in those patients, one might assume that reduced inhibition is the cause of their stones. This hypothesis was tested in 25 patients who formed at least ten stones each, yet lacked the usual metabolic abnormalities that increase supersaturation. Compared with 25 age- and sex-matched control subjects, urine supersaturation among the patients was not increased; this is an expected result of this study's selection criteria. Compared with the same age- and sex-matched control subjects, urine from the patients showed no evidence for reduced inhibition of calcium oxalate crystal growth, so low inhibition of growth did not contribute to pathogenesis of stones in our highly selected study population, despite their otherwise unexplained and active stone formation. These results do not support the hypothesis that growth inhibition defects are a cause of stone disease.


2015 ◽  
Vol 3 (1) ◽  
pp. 8
Author(s):  
Afrizal Itam ◽  
Zhari Ismail ◽  
Amin Malik Shah Abdul Majid

 ABSTRACT Strobilanthes crispus L. (Acanthaceae) has been used locally in traditional medicine for kidney stone and related diseases. These plant extracts have the ability to inhibit the calcium oxalate crystal growth, where the ability of water extract is higher than those of the 70% acetone, methanol and acetone extracts. The ability to inhibit the calcium oxalate crystal growth of these extracts is lower than that of sodium citrate as positive control. Keywords: Strobilanthes crispus, Acanthaceae, crystal inhibition, calcium oxalate


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