Influence of Rheological Therapy on Regional Cerebral Blood Flow in Patients with Cerebrovascular Disease

Using the 133Xe-DSPECT technique, quantitative measurements of regional cerebral blood flow (rCBF) were performed before and after provocation with acetazolamide (Diamox) i. v. in 32 patients without evidence of brain disease (normals). In 6 cases, additional studies were carried out to establish the time of maximal rCBF increase which was found to be approximately 15 min p. i. 1 g of Diamox increases the rCBF from 58 ±8 at rest to 73±5 ml/100 g/min. A Diamox dose of 2 g (9 cases) causes no further rCBF increase. After plotting the rCBF before provocation (rCBFR) and the Diamox-induced rCBF increase (reserve capacity, Δ rCBF) the regression line was Δ rCBF = −0,6 x rCBFR +50 (correlation coefficient: r = −0,77). In normals with relatively low rCBF values at rest, Diamox increases the reserve capacity much more than in normals with high rCBF values before provocation. It can be expected that this concept of measuring rCBF at rest and the reserve capacity will increase the sensitivity of distinguishing patients with reversible cerebrovascular disease (even bilateral) from normals.

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Pitfalls of Regional Cerebral Blood Flow Analysis in Cerebrovascular Disease

Clinical Nuclear Medicine ◽

10.1097/00003072-198803000-00016 ◽

1988 ◽

Vol 13 (3) ◽

pp. 197-201 ◽

Cited By ~ 9

Author(s):

HANS L. LAGREZE ◽

ROSS L. LEVINE ◽

JOHN S. SUNDERLAND ◽

ROBERT J. NICKLES

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Cerebrovascular Disease ◽

Regional Cerebral Blood Flow ◽

Flow Analysis ◽

Regional Cerebral Blood ◽

Blood Flow Analysis

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A Controlled Study on the Effect of Pentoxifylline and an Ergot Alkaloid Derivative on Regional Cerebral Blood Flow in Patients with Chronic Cerebrovascular Disease

Angiology ◽

10.1177/000331978803900507 ◽

1988 ◽

Vol 39 (5) ◽

pp. 449-457 ◽

Cited By ~ 14

Author(s):

Alexander Hartmann ◽

Yoshiyasu Tsuda

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Cerebrovascular Disease ◽

Ergot Alkaloid ◽

Regional Cerebral Blood Flow ◽

Controlled Study ◽

Regional Cerebral Blood

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CT AND REGIONAL CEREBRAL BLOOD FLOW IN ESTIMATION OF THE PROGNOSIS OF APHASIC SYMPTOMS DUE TO CEREBROVASCULAR DISEASE

The Japanese Journal of Rehabilitation Medicine ◽

10.2490/jjrm1963.17.165 ◽

1980 ◽

Vol 17 (3) ◽

pp. 165-173

Author(s):

Ken NAGATA

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Cerebrovascular Disease ◽

Regional Cerebral Blood Flow ◽

Regional Cerebral Blood

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Combined SPECT Imaging of Regional Cerebral Blood Flow (99mTc-HexamethylPropyleneamine Oxime, HMPAO) and Blood Volume (99mTc-RBC) to Assess Regional Cerebral Perfusion Reserve in Patients with Cerebrovascular Disease

Nuklearmedizin ◽

10.1055/s-0038-1629503 ◽

1988 ◽

Vol 27 (02) ◽

pp. 51-56 ◽

Cited By ~ 10

Author(s):

H. Braun ◽

A. Ferbert ◽

H. Stirner ◽

C. Weiller ◽

E. B. Ringelstein ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Cerebrovascular Disease ◽

Blood Volume ◽

Cerebral Perfusion ◽

Regional Cerebral Blood Flow ◽

Regional Cerebral Blood ◽

Perfusion Reserve ◽

Promising Tool ◽

Semiquantitative Evaluation

In 53 patients with cerebrovascular disease (CVD), regional cerebral blood flow (CBF) and blood volume (CBV) were imaged by SPECT within one session. Slice division (CBF: CBV) yielded distribution of regional cerebral perfusion reserve (CPR). Semiquantitative evaluation was obtained from manually set ROIs by interhemispherical ratios (for CBF, CBV and CPR), using 2 SD from a normal group (n = 10) as a threshold. Sensitivities were 59% for CBF, 94% for CBV and 83% for CPR. Combined sensitivity was 98%. Establishing three constellations for CBF, CBV and CPR, regionally normal CBFs but quantitatively increased CBVs (+69%) and decreased CPRs (−31 %) were found in relatively early stages of CVD. Very advanced cases showed decreased CBFs (−65%), CBVs (−40%), CPRs (−49%) and a surrounding penumbra. In 87% (46/53 patients), such Theologically postulated constellations could be demonstrated. We conclude that combined CBF and CBV SPECT, assisted by CPR images, is a promising tool to detect CVD and to assess its individual regional severity.

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