Effect of Ribomononucleotides Given Orally on Uric Acid Production in Man

1974 ◽  
pp. 443-449 ◽  
Author(s):  
A. Griebsch ◽  
N. Zöllner
Keyword(s):  
Uric Acid ◽  
Acid Production

Chain-breaking/Preventive Antioxidant, Urate-lowering, and Anti-inflammatory Effects of Pure Curcumin

2020 ◽  
Vol 17 (1) ◽  
pp. 66-74
Author(s):  
Seghira Bisset ◽  
Widad Sobhi ◽  
Chawki Bensouici ◽  
Abdelhalim Khenchouche
Keyword(s):  
Uric Acid ◽  
Xanthine Oxidase ◽  
Acid Production ◽  
Biological Activities ◽  
Antioxidant Effect ◽  
Metal Chelating ◽  
Wide Range ◽  
Chain Breaking ◽  
Pharmaceutical Industries ◽  
Anti Inflammatory

Background: Several researches have shown that therapeutic compounds or phytochemicals from natural sources are important in the food as it is valuable in pharmaceutical industries due to their fewer side effects and potent against various diseases. Curcumin, a major polyphenol derived from turmeric spice, which used in many foods, has a wide range of biological activities, with quite a safety. Objective: The goal of this study was to investigate the antioxidant, urate-lowering, and antiinflammatory effects of pure curcumin. Methods: The antioxidant activity was evaluated for chain-breaking antioxidant effect (radicalscavenging and reducing abilities assays) and for preventive antioxidant effect with metal chelating assay, the urate-lowering was assayed on aspectrophotometer by measuring the inhibition of uric acid production by xanthine oxidase (XO) enzyme, and the anti-inflammatory effect was estimated using in vitro albumin denaturation inhibition. Results: Curcumin showed a significant and good chain-breaking antioxidant effect, both in free radical- scavenging assays (Galvinoxyl radical, ABTS, and hydroxyl radical), and in reducing abilities methods (reducing power, Cupric ion reducing antioxidant capacity and O-phenanthroline assays). In preventive antioxidant effect, assessed with the metal chelating assay, curcumin showed significant effect but with high concentration compared with standard. In the xanthine/xanthine oxidase system, curcumin significantly inhibited uric acid production (IC50=0.71 ± 0.06 mg/mL). Regarding antiinflammatory activity, curcumin showed significant inhibition of albumin denaturation with an IC50 value of 1181.69 ± 1.11μg/mL. Conclusion: These results indicated that curcumin showed promising antioxidant, anti-gout and antiinflammatory properties and might be used as potential, natural drugs against oxidative and inflammation- related diseases.

scholarly journals Xanthine Oxidase of the Clothes Moth, Tineola Bisselliella, and Some Other Insects

1955 ◽  
Vol 8 (3) ◽  
pp. 369 ◽  
Author(s):  
H Irzykiewicz
Keyword(s):  
Methylene Blue ◽  
Uric Acid ◽  
Toxic Effect ◽  
Xanthine Oxidase ◽  
Oxidase Activity ◽  
Acid Production ◽  
Fat Body ◽  
Optimum Concentration ◽  
Optimum Ph ◽  
Wet Weight

Xanthine oxidase activity in Tineola larvae averages 200� /!moles of uric acid per g whole larva (wet weight) per hr and in Tenebrio, Lucilia, Anthrenocerus, Ephestia, and Anthrenus larvae activity ranges between 13�4 and 1�3. The optimum pH for Tineola xanthine oxidase lies between pH 7�7 and 8� 0, and the optimum concentration of xanthine is at or below 1�3 X 10-3M. Methylene blue in concentrations up to 5�3 X 1O-3M has no toxic effect on this enzyme, and the lower concentrations of methylene blue have a limiting effect. Cyanide and 6-pteridyl aldehyde inhibit Tineola xanthine oxidase. The insect xanthine oxidases are demonstrated to be dehydrogenases. DPN, and pyruvate and DPN together, stimulate uric acid production by Tineola xanthine oxidase in the absence of methylene blue. In Tenebrio larvae there is a higher concentration of xanthine oxidase in the midgut and fat-body than in the remaining tissues.

scholarly journals Goose astrovirus infection affects uric acid production and excretion in goslings

2020 ◽  
Vol 99 (4) ◽  
pp. 1967-1974 ◽  
Author(s):  
Wankun Wu ◽  
Rong Xu ◽  
Yingjun Lv ◽  
Endong Bao
Keyword(s):  
Uric Acid ◽  
Acid Production

Effect of Ethanol on Uric Acid Production of Human Liver

1977 ◽  
Vol 21 (1) ◽  
pp. 138-141 ◽  
Author(s):  
J. Grunst ◽  
G. Dietze ◽  
M. Wicklmayr
Keyword(s):  
Uric Acid ◽  
Acid Production ◽  
Human Liver

A New-Generation Uric Acid Production Inhibitor: Febuxostat

2012 ◽  
pp. 365-376
Author(s):  
Ken Okamoto ◽  
Shiro Kondo ◽  
Takeshi Nishino
Keyword(s):  
Uric Acid ◽  
Acid Production ◽  
New Generation

Decreased first trimester uric acid production in future preeclamptic patients

1997 ◽  
Vol 25 (4) ◽  
pp. 347-352 ◽  
Author(s):  
Catharina L. D. de Jong ◽  
K. Marieke Paarlberg ◽  
Herman P. van Geijn ◽  
Elbert Jaap I. Schipper ◽  
Aalt Bast ◽  
...  
Keyword(s):  
Uric Acid ◽  
Acid Production ◽  
First Trimester
Sign in / Sign up

Export Citation Format

Share Document